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1. Synthesis and antitumor activity of aminoacid derivatives of the antimetastatic agent DM-COOK.

Author

Lassiani L, de Nardo MM, Nisi C, and Varnavas A

Subjects
Animals, Antineoplastic Agents pharmacology, Chemical Phenomena, Chemistry, Leukemia P388 drug therapy, Magnetic Resonance Spectroscopy, Mice, Mice, Inbred Strains, Neoplasm Metastasis, Triazenes pharmacology, Antineoplastic Agents chemical synthesis, Triazenes chemical synthesis
Abstract

Esters and amides of N-(3,3-dimethyl-1-triazeno)benzoylamino acids have been synthesized as inhibitors of cell surface neutral proteases. Preliminary data on activity against P-388 lymphocytic leukemia are also reported.

Published
1988

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