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This research was carried out to evaluate the antidiabetic effects of zinc oxide nanoparticles (ZnO NPs) and thiamine following experimental diabetes. Fifty-six 6-week-old female mice were used and divided into seven groups of eight animals. Diabetes was induced in fasted mice by using intraperitoneal (IP) injection of alloxan (180 mg/kg). Groups included (I) non-diabetic control, (II) thiamine (30 mg/l, IP), (III) alloxan-induced diabetic mice, (IV) diabetes + ZnO NPs (0.1 mg/kg IP), (V) diabetes + ZnO NPs (0.5 mg/kg IP), (VI) diabetes + ZnO NPs (0.1 mg/kg IP) + thiamine (30 mg/l, IP), and (VII) diabetes + ZnO NPs (0.5 mg/kg IP) + thiamine (30 mg/l, IP). Coincident with pancreas recovery, in diabetic treated mice (groups IV to VII), the mean islet volume, islets per square micrometer, and volume density of the pancreas had increased than in alloxan-induced diabetic mice. ZnO NPs and thiamine induced a decreasing blood glucose, lower serum triglyceride (TG), LDL, and total cholesterol (TC) levels in alloxan-induced diabetic mice treated with ZnO NPs and thiamine, simultaneously increasing HDL as well. In conclusion, ZnO NPs and thiamine are potent antidiabetic factors, and that, these compound supplementation possesses hypoglycemic properties and have effect on serum lipid parameters in diabetes mice.

Thyme is a plant native to Iran that is widely found in southern part and mountainous center of country and has antibacterial and antifungal activity on digestive and chronic diseases in traditional medicine. However the medicinal species is called Thyme vulgaris, all of the Thyme are enriched with volatile compounds including thymol and carvacrol acting as strong antiseptic. In present study we decided on evaluating the effect of thyme essence on biochemical factors such as (triglyceride, cholesterol, HDL, LDL, ALT, AST and total protein) in rat's blood serum. In this study thyme essences in 200 and 400 mg/kg levels were prescribed respectively for animals in two treatment group through oral administration during 21 days and the third group as control received no compositions. In this study it was observed that after measuring biochemical factors of blood serum the thyme essences led to decrease cholesterol level significantly in both treatment groups compared with control group (p

The Ziziphora tenuior L. is an herbaceous, plant rich in essential oil. Ziziphora tenuior L. has antibacterial and disinfection effect and its vapour is used to treat respiratory tract problems and removing symptoms of the common cold. This plant is carminative, promotes expelling of phlegm and sputum and is a tonic for the stomach. To perform this study some chemical factors (triglyceride, cholesterol, HDL, LDL, ALT, AST and total protein) of the rat's serum were measured in the clinical laboratory. In this study, number of 24 white male wistar rats with the weight range of 215 ± 15 g and at 10 weeks of age were prepared from the Laboratory Animals Breeding Center of the University. Rats were divided into three classes of 8 and 200 mg/kg and 400 mg/kg of the Ziziphora tenuior L. plant essence was used in groups 1 and 2 respectively and no plant compound was used in the third group as the control group. The plant was prescribed for 21 days in groups. Amount of the cholesterol, ALT and triglyceride factors showed the significant difference compared to the control group.