Search

Abstract: The convenient synthesis of new functionalized organophosphorus acids and their derivatives containing indan moieties was developed. The regioselective radical addition of bis(trimethylsiloxy)phosphine to indene proceeds to give rise to 2‐indanylphosphonite as key compound for preparation of above acids with bicyclic substituents. Azobis(isobutyronitrile) (AIBN) in the conditions of its thermolysis was used as effective initiator of the addition reaction. The further treatment of organophosphorus acids trimethylsilyl esters with the methanolic sodium methoxide solution resulted in the water‐soluble sodium salts of the corresponding acids. [ABSTRACT FROM AUTHOR]

The addition of trimethylsilyl esters of trivalent phosphorus acids to trimethylsilyl ester of 1 H-indene-3-carboxylic acid has been studied. The convenient syntheses of new functionalized organophosphorus acids and their derivatives with indan-1-carboxylic acid moieties have been proposed. Water-soluble sodium salts of the corresponding acids were also obtained. [ABSTRACT FROM AUTHOR]

The convenient methods for the synthesis of new trimethylsilyl esters of aminomethylenediphosphonic acids are elaborated. The new substituted N-formylaminomethylenediphosphonates are obtained via the interaction of trimethylsilyl esters of methylenediphosphonic acids with a mixture of triethyl orthoformate and ethanol. Also boron trifluoride-diethyl etherate as an effective catalyst is used for the interaction of hydrochlorides of ethoxymethylene imines with diethyl trimethylsilyl phosphite. The corresponding aminomethylenediphosphonic acids are presented. [ABSTRACT FROM AUTHOR]

ABSTRACT The interaction of trimethylsilyl esters of trivalent organophosphorus acids containing PH and POSiMe3 groups with hydrochlorides of ethoxymethylene imines is a convenient method for the synthesis of new trimethylsilyl esters of N-unsubstituted aminomethylenebisorganophosphorus acids with three and four coordinated phosphorus. Also trimethylsilyl trifluoromethanesulfonate as effective catalyst is used for the similar interaction of hydrochlorides of ethoxymethylene imines with tris(trimethylsilyl)phosphite. The corresponding bisorganophosphorus acids and their derivatives are presented. [ABSTRACT FROM AUTHOR]

The new functionalized hydroxymethylphosphonic and methylenebis(phosphonic) acids are synthesized via reaction of tris(trimethylsilyl) phosphite and N -formyl derivatives of five-membered N-heterocycles in the presence of trimethylsilyl triflate. [ABSTRACT FROM AUTHOR]

The new functionalized hydroxymethylphosphonic and methylenediphosphonic acids are synthesized via unique reaction of tris(trimethylsilyl) phosphite and N -formyl N -heterocycles, N-substituted 4-piperidones, 3-quinuclidone, and 2-adamantanone at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. [ABSTRACT FROM AUTHOR]

Graphical abstract Highlights • New aminomethylphosphinic acids with 4-hydroxypiperidine moieties were synthesized. • Reaction with various aminals proceeds under mild conditions to give PH-phosphinates. • New phosphinic acids were obtained by methanolysis. • Final compounds are promising bioactive substances and polydentate ligands. Abstract The convenient synthesis of new aminomethylphosphinic acids and their derivatives containing N -alkyl 4-hydroxypiperidines moieties was developed. The addition of bis(trimethylsiloxy)phosphine to N -alkyl 4-piperidones proceeds under mild conditions to give PH-phosphinates as key compounds for preparation of trimethylsilyl esters of above acids via interaction with various aminals. The further treatment of phosphinic acids trimethylsilyl esters with the methanol resulted in the water-soluble corresponding acids. The structures of aminomethylphosphinic acids and their precusors 1 – 3 with substituted piperidine moieties were confirmed by the 1H, 13C, 31P NMR spectra. [ABSTRACT FROM AUTHOR]

The article presents chemical equations related to the article "Synthesis and Reactivity of the New Trimethylsilyl Esters of Aminomethylenebisorganophosphorus Acids" by M.V. Livantsov, O.P. Novikova, I.S. Ershov and others, published in the periodical "Heteroatom Chemistry" in 2013.