1. Bent and linear trinuclear nickel complexes with ligands derived from N-acylsalicylhydrazide ligands: structural characterization and bioactivity.
- Author
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Luo, Wei, Meng, Xiang-Gao, Cheng, Gong-Zhen, and Ji, Zhen-Ping
- Subjects
LIGANDS (Chemistry) ,X-ray crystallography ,NICKEL ,IONS ,METAL ions ,CARBENES - Abstract
Two trinuclear Ni(II) complexes Ni3(L1)2(py)2(DMF)(H2O) (1) and Ni3(L2)2(py)2(DMF)2 (2) with two new trianionic pentadentate ligands N-(3,5-dimethylbenzoyl)-salicylhydrazide (H3L1) and N-(phenylacetyl)-5-nitrosalicylhydrazide (H3L2) have been synthesized and characterized by X-ray crystallography. Nickel ions in the two complexes have square-planar/octahedral/square-planar coordination. Central metal ion and two terminal metal ions in the two complexes are combined by two bridging deprotonated ligands, forming a trinuclear structural unit with an M-N-N-M-N-N-M core. Studies on the trinuclear Ni(II) complexes show that the β-branched N-acylsalicylhydrazide ligands with sterically flexible Cα methylene groups yield linear trinuclear Ni(II) complexes, while α-branched N-acylsalicylhydrazide ligands tend to form bent trinuclear Ni(II) complexes. Antibacterial screening data in a previous study indicates that bent trinuclear Ni(II) compound 1 is more active than linear compound 2 and less active than a tetranuclear nickel compound. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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