1. Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus .
- Author
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Ye ZJ, Sun HH, Chen ZH, Wu JP, Li J, Zhu H, Huang LL, Chang XW, Ou SY, Wang WX, He XA, Zhu GZ, and Xu KP
- Subjects
- Glycosides pharmacology, Plant Leaves, Xanthine Oxidase, Juglandaceae, Triterpenes
- Abstract
Four new prenylflavonol glycosides ( 1-4 ) along with two known analogues ( 5-6 ) were isolated from the leaves of Cyclocarya paliurus for the first time. The structures of these compounds were characterized by comprehensive analysis of 1 D, 2 D NMR, HRESIMS, UV data and enzymatic hydrolysis. In bioassays, compounds 1-4 were evaluated for inhibitory effects on xanthine oxidase (XOD) and effects on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW264.7 cells. Moreover, compounds 1 and 2 showed outstanding XOD inhibitions with IC
50 values of 18.16 ± 3.91 and 37.65 ± 5.67 µM, and exhibited inhibitions against LPS-induced NO production with IC50 values of 80.50 ± 3.09 and 82.28 ± 2.87 µM.- Published
- 2022
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