10 results on '"Dumonteil, Eric"'
Search Results
2. Estimating the current burden of Chagas disease in Mexico: A systematic review and meta-analysis of epidemiological surveys from 2006 to 2017.
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Arnal, Audrey, Waleckx, Etienne, Rico-Chávez, Oscar, Herrera, Claudia, and Dumonteil, Eric
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CHAGAS' disease ,META-analysis ,DISEASE prevalence ,PREGNANT women ,TRYPANOSOMA cruzi - Abstract
Background: In Mexico, estimates of Chagas disease prevalence and burden vary widely. Updating surveillance data is therefore an important priority to ensure that Chagas disease does not remain a barrier to the development of Mexico's most vulnerable populations. Methodology/Principal findings: The aim of this systematic review and meta-analysis was to analyze the literature on epidemiological surveys to estimate Chagas disease prevalence and burden in Mexico, during the period 2006 to 2017. A total of 2,764 articles were screened and 36 were retained for the final analysis. Epidemiological surveys have been performed in most of Mexico, but with variable study scale and geographic coverage. Based on studies reporting confirmed cases (i.e. using at least 2 serological tests), and taking into account the differences of sample sizes, the national estimated seroprevalence of Trypanosoma cruzi infection was 3.38% [95%CI 2.59–4.16], suggesting that there are 4.06 million cases in Mexico. Studies focused on pregnant women, which may transmit the parasite to their newborn during pregnancy, reported an estimated seroprevalence of 2.21% [95%CI 1.46–2.96], suggesting that there are 50,675 births from T. cruzi infected pregnant women per year, and 3,193 cases of congenitally infected newborns per year. Children under 18 years had an estimated seropositivity rate of 1.51% [95%CI 0.77–2.25], which indicate ongoing transmission. Cases of T. cruzi infection in blood donors have also been reported in most states, with a national estimated seroprevalence of 0.55% [95%CI 0.43–0.66]. Conclusions/Significance: Our analysis suggests a disease burden for T. cruzi infection higher than previously recognized, highlighting the urgency of establishing Chagas disease surveillance and control as a key national public health priority in Mexico, to ensure that it does not remain a major barrier to the economic and social development of the country's most vulnerable populations. [ABSTRACT FROM AUTHOR]
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- 2019
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3. A therapeutic preconceptional vaccine against Chagas disease: A novel indication that could reduce congenital transmission and accelerate vaccine development.
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Dumonteil, Eric, Herrera, Claudia, and Buekens, Pierre
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CHAGAS' disease , *VACCINES , *DNA vaccines , *COMBINATION drug therapy - Abstract
The article offers information on the Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite Trypanosoma cruzi, and has limited treatment options with two drugs available Benznidazole and Nifurtimox. It states that therapeutic vaccination has been proposed for the control of T. cruzi infection. It mentions that preconceptional vaccine aimed at preventing future congenital transmission of the parasite would be good for control of the disease.
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- 2019
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4. Non-randomized controlled trial of the long-term efficacy of an Ecohealth intervention against Chagas disease in Yucatan, Mexico.
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Waleckx, Etienne, Pérez-Carrillo, Silvia, Chávez-Lazo, Samuel, Pasos-Alquicira, Rafael, Cámara-Heredia, María, Acuña-Lizama, Jesús, Collí-Balám, Fernando, Cámara-Mejía, Javier, Ramírez-Sierra, Maria Jesús, Cruz-Chan, Vladimir, Rosado-Vallado, Miguel, Vázquez-Narvaez, Santos, Najera-Vázquez, Rosario, Gourbière, Sébastien, and Dumonteil, Eric
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TRYPANOSOMA cruzi ,INSECTICIDES ,RANDOMIZED controlled trials ,DISEASE vectors ,ENTOMOLOGY - Abstract
Non-domiciliated intrusive triatomine vectors are responsible for a low but significant transmission of Trypanosoma cruzi to humans. Their control is a challenge as insecticide spraying is of limited usefulness, and alternative strategies need to be developed for a sustainable control. We performed a non-randomized controlled trial of an Ecohealth intervention based on window insect screens and community participation to reduce house infestation by Triatoma dimidiata in two rural villages in Yucatan, Mexico. Efficacy of the intervention was measured over a three years follow-up period and entomological indicators showed that the proportion of triatomines found inside houses was significantly reduced in houses with insect screens, which effectively kept more bugs on the outside of houses. Using a previously developed model linking entomological data to the prevalence of infection in human, we predicted that the intervention would lead to a 32% reduction in yearly incidence and in the prevalence of T. cruzi infection. The cost for the coverage of all the windows of a house was of comparable magnitude to what families currently spend on various domestic insecticide, and most screens were still in good conditions after three years. In conclusion, the Ecohealth approach proposed here is effective for the long-term and sustainable control of intrusive T. dimidiata vectors in the Yucatan peninsula, Mexico. This strategy may also be easily adapted to other intrusive triatomine species as well as other regions/countries with comparable eco-epidemiological settings, and would be an excellent component of a larger integrated program for the control of a variety of other vector-borne diseases, bringing additional benefits to the communities. Our results should encourage a further scaling-up of our implementation strategy in additional villages in the region. [ABSTRACT FROM AUTHOR]
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- 2018
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5. Are the London Declaration’s 2020 goals sufficient to control Chagas disease?: Modeling scenarios for the Yucatan Peninsula.
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Lee, Bruce Y., Bartsch, Sarah M., Skrip, Laura, Hertenstein, Daniel L., Avelis, Cameron M., Ndeffo-Mbah, Martial, Tilchin, Carla, Dumonteil, Eric O., and Galvani, Alison
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CHAGAS' disease prevention ,CHAGAS' disease ,DISEASE vectors ,SIMULATION methods & models ,INFECTIOUS disease transmission - Abstract
Background: The 2020 Sustainable Development goals call for 100% certified interruption or control of the three main forms of Chagas disease transmission in Latin America. However, how much will achieving these goals to varying degrees control Chagas disease; what is the potential impact of missing these goals and if they are achieved, what may be left? Methods: We developed a compartmental simulation model that represents the triatomine, human host, and non-human host populations and vector-borne, congenital, and transfusional T. cruzi transmission between them in the domestic and peridomestic settings to evaluate the impact of limiting transmission in a 2,000 person virtual village in Yucatan, Mexico. Results: Interruption of domestic vectorial transmission had the largest impact on T. cruzi transmission and prevalence in all populations. Most of the gains were achieved within the first few years. Controlling vectorial transmission resulted in a 46.1–83.0% relative reduction in the number of new acute Chagas cases for a 50–100% interruption in domestic vector-host contact. Only controlling congenital transmission led to a 2.4–8.1% (30–100% interruption) relative reduction in the total number of new acute cases and reducing only transfusional transmission led to a 0.1–0.3% (30–100% reduction). Stopping all three forms of transmission resulted in 0.5 total transmission events over five years (compared to 5.0 with no interruption); interrupting all forms by 30% resulted in 3.4 events over five years per 2,000 persons. Conclusions: While reducing domestic vectorial, congenital, and transfusional transmission can successfully reduce transmission to humans (up to 82% in one year), achieving the 2020 goals would still result in 0.5 new acute cases per 2,000 over five years. Even if the goals are missed, major gains can be achieved within the first few years. Interrupting transmission should be combined with other efforts such as a vaccine or improved access to care, especially for the population of already infected individuals. [ABSTRACT FROM AUTHOR]
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- 2018
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6. Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico.
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Villanueva-Lizama, Liliana E., Cruz-Chan, Julio V., Aguilar-Cetina, Amarú del C., Herrera-Sanchez, Luis F., Rodriguez-Perez, Jose M., Rosado-Vallado, Miguel E., Ramirez-Sierra, Maria J., Ortega-Lopez, Jaime, Jones, Kathryn, Hotez, Peter, Bottazzi, Maria Elena, and Dumonteil, Eric
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TRYPANOSOMA cruzi ,ANTIGENS ,IMMUNE response ,IN vitro studies ,T cells ,BLOOD cells ,VACCINATION - Abstract
Trypanosoma cruzi antigens TSA-1 and Tc24 have shown promise as vaccine candidates in animal studies. We evaluated here the recall immune response these antigens induce in Chagasic patients, as a first step to test their immunogenicity in humans. We evaluated the in vitro cellular immune response after stimulation with recombinant TSA-1 (rTSA-1) or recombinant Tc24 (rTc24) in mononuclear cells of asymptomatic Chagasic chronic patients (n = 20) compared to healthy volunteers (n = 19) from Yucatan, Mexico. Proliferation assays, intracellular cytokine staining, cytometric bead arrays, and memory T cell immunophenotyping were performed by flow cytometry. Peripheral blood mononuclear cells (PBMC) from Chagasic patients showed significant proliferation after stimulation with rTc24 and presented a phenotype of T effector memory cells (CD45RA
- CCR7- ). These cells also produced IFN-γ and, to a lesser extent IL10, after stimulation with rTSA-1 and rTc24 proteins. Overall, both antigens recalled a broad immune response in some Chagasic patients, confirming that their immune system had been primed against these antigens during natural infection. Analysis of HLA-A and HLA-B allele diversity by PCR-sequencing indicated that HLA-A03 and HLA-B07 were the most frequent supertypes in this Mexican population. Also, there was a significant difference in the frequency of HLA-A01 and HLA-A02 supertypes between Chagasic patients and controls, while the other alleles were evenly distributed. Some aspects of the immune response, such as antigen-induced IFN-γ production by CD4+ and CD8+ T cells and CD8+ proliferation, showed significant association with specific HLA-A supertypes, depending on the antigen considered. In conclusion, our results confirm the ability of both TSA-1 and Tc24 recombinant proteins to recall an immune response induced by the native antigens during natural infection in at least some patients. Our data support the further development of these antigens as therapeutic vaccine against Chagas disease. [ABSTRACT FROM AUTHOR]- Published
- 2018
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7. Ten years of Chagas disease research: Looking back to achievements, looking ahead to challenges.
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Dumonteil, Eric and Herrera, Claudia
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CHAGAS' disease treatment , *TRYPANOSOMIASIS , *TROPICAL medicine , *TRYPANOSOMA cruzi , *ENDEMIC diseases - Abstract
The article examines achievements and challenges in research related to Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a neglected tropical disease (NTD) with a high disease burden in the Americas. It reports how estimates of Chagas disease burden and its epidemiological impact provide the basis for health interventions in both endemic and nonendemic countries.
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- 2017
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8. Chagas Disease Has Not Been Controlled in Ecuador.
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Dumonteil, Eric, Herrera, Claudia, Martini, Luiggi, Grijalva, Mario J., Guevara, Angel G., Costales, Jaime A., Aguilar, H. Marcelo, Brenière, S. Frédérique, and Waleckx, Etienne
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CHAGAS' disease , *PROTOZOAN diseases , *PARASITIC protozoa , *TRYPANOSOMA cruzi - Published
- 2016
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9. Highly discordant serology against Trypanosoma cruzi in central Veracruz, Mexico: role of the antigen used for diagnostic.
- Author
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Guzmán-Gómez, Daniel, López-Monteon, Aracely, de la Soledad Lagunes-Castro, María, Álvarez-Martínez, Carolina, Hernández-Lutzon, Manuel Jesús, Dumonteil, Eric, and Ramos-Ligonio, Angel
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TRYPANOSOMA cruzi ,CHAGAS' disease ,ENZYME-linked immunosorbent assay ,TRYPANOSOMA ,TRYPANOSOMIASIS - Abstract
Background: Chagas disease is a parasitic disease caused by the protozoan parasite Trypanosoma cruzi. In Mexico, the burden of the disease is difficult to estimate and improving surveillance for Chagas disease is an important priority. We aimed here at determining the seroprevalence of T. cruzi infection in humans in a rural community in Veracruz. Methods: Serum samples (196) were analyzed for T. cruzi infection using five enzyme-linked immunosorbent assay (ELISA) tests: two in-house tests based on crude parasite extract and three commercial ELISA kits. Because of highly discordant results, we further explored the importance of parasite antigens and strains by western-blot analysis. Results: A total of 74 samples (37.7 %) were reactive with at least one ELISA, but discordance among tests was very high. The best agreement was between Chagatest recombinant and Chagatek ELISA (Kappa index = 0.798). The agreement between other combinations of tests ranged from 0.038 to 0.518. Discordant samples were confirmed by western-blot analysis using up to nine parasite strains, giving a seroprevalence of 33.7 %. Conclusions: Commercial tests had a very limited ability to detect T. cruzi infection in the study population. In-house tests based on crude parasite antigens showed a greater sensitivity but were still unable to detect all cases of T. cruzi infection, even when based on a local parasite strain. The high seroprevalence confirmed the hyper-endemicity of T. cruzi infection in the region. Reliable epidemiological surveillance of Chagas disease will require the development of improved diagnostic tests. [ABSTRACT FROM AUTHOR]
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- 2015
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10. Therapeutic DNA Vaccine against Trypanosoma cruzi Infection in Dogs.
- Author
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Quijano‐Hernandez, Israel Alejandro, Bolio‐González, Manuel Emilio, Rodríguez‐Buenfil, Jorge Carlos, Ramirez‐Sierra, María Jesus, and Dumonteil, Eric
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CHAGAS' disease ,TRYPANOSOMIASIS ,TRYPANOSOMA ,PREVENTIVE medicine ,VACCINES ,GENES ,DNA ,ALTERNATIVE medicine - Abstract
Chagas' disease is an important health problem in most Latin American countries, and a concern in dog populations, which act as a reservoir. We showed in previous studies that a therapeutic DNA vaccine could partially control the pathology after Trypanosoma cruzi infection in mice, and this vaccine may represent an alternative treatment for Chagas' disease. Here we evaluated the therapeutic efficacy of this vaccine in experimentally infected dogs for up to 2 months after infection. Our results suggest that DNA vaccine treatment may affect the immune response and delay Chagas' disease progression in T. cruzi–infected dogs, and confirm the potential of this novel treatment. [ABSTRACT FROM AUTHOR]
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- 2008
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