1. The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population.
- Author
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Testi, Ilaria, Agrawal, Rupesh, Mahajan, Sarakshi, Agarwal, Aniruddha, Gunasekeran, Dinesh Visva, Raje, Dhananjay, Aggarwal, Kanika, Murthy, Somasheila I., Westcott, Mark, Chee, Soon-Phaik, Mccluskey, Peter, Ho, Su Ling, Teoh, Stephen, Cimino, Luca, Biswas, Jyotirmay, Narain, Shishir, Agarwal, Manisha, Mahendradas, Padmamalini, Khairallah, Moncef, and Jones, Nicholas
- Subjects
CHILD patients ,OPTIC disc edema ,UVEITIS ,TUBERCULOSIS ,SYMPTOMS ,IRIDOCYCLITIS - Abstract
Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. Results: Mean age of disease presentation was 12.8 (range 4โ18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (P =.006). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21). Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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