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Your search keyword '"Gong, Siming"' showing total 2 results
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2 results on '"Gong, Siming"'

1. Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)

Author

Wu, Changwu, Duan, Yingjuan, Gong, Siming, Kallendrusch, Sonja, Schopow, Nikolas, and Osterhoff, Georg

Subjects
tumor, Carcinogenesis, QH301-705.5, Cell Cycle Proteins, Kaplan-Meier Estimate, CD8-Positive T-Lymphocytes, Article, enrichment analysis, Cancer-Associated Fibroblasts, big data, Neoplasms, Databases, Genetic, Guanine Nucleotide Exchange Factors, Humans, Protein Interaction Maps, Phosphorylation, Biology (General), QD1-999, immune infiltration, Cell Cycle, Nuclear Proteins, pancancer, DNA Methylation, Immune Checkpoint Proteins, Chromatin, Gene Expression Regulation, Neoplastic, RCC1, Chemistry, Gene Ontology, Microsatellite Instability, prognosis, Transcriptome
Abstract

Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.

Published
2021

2. A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3).

Author

Gong, Siming, Duan, Yingjuan, Wu, Changwu, Osterhoff, Georg, Schopow, Nikolas, and Kallendrusch, Sonja

Subjects
*SYSTEM analysis, *GENE amplification, *ENDOMETRIAL cancer, *SARCOMA, *PROGNOSIS, *BIOMARKERS
Abstract

The overexpression of the enzymes involved in the degradation of procollagen lysine is correlated with various tumor entities. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) expression was found to be correlated to the progression and migration of cancer cells in gastric, lung and prostate cancer. Here, we analyzed the gene expression, protein expression, and the clinical parameters of survival across 33 cancers based on the Clinical Proteomic Tumor Analysis Consortium (CPTAC), function annotation of the mammalian genome 5 (FANTOM5), Gene Expression Omnibus (GEO), Genotype-Tissue Expression (GTEx), Human Protein Atlas (HPA) and The Cancer Genome Atlas (TCGA) databases. Genetic alteration, immune infiltration and relevant cellular pathways were analyzed in detail. PLOD3 expression negatively correlated with survival periods and the infiltration level of CD8+ T cells, but positively correlated to the infiltration of cancer associated fibroblasts in diverse cancers. Immunohistochemistry in colon carcinomas, glioblastomas, and soft tissue sarcomas further confirm PLOD 3 expression in human cancer tissue. Moreover, amplification and mutation accounted for the largest proportion in esophageal adenocarcinoma and uterine corpus endometrial carcinoma, respectively; the copy number alteration of PLOD3 appeared in all cancers from TCGA; and molecular mechanisms further proved the effect of PLOD3 on tumorigenesis. In particular, PLOD3 expression appears to have a tumor immunological effect, and is related to multiple immune cells. Furthermore, it is also associated with tumor mutation burden and microsatellite instability in various tumors. PLOD3 acts as an inducer of various cancers, and it could be a potential biomarker for prognosis and targeted treatment. [ABSTRACT FROM AUTHOR]

Published
2021
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