1. Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases.
- Author
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Teunissen CE, Veerhuis R, De Vente J, Verhey FR, Vreeling F, van Boxtel MP, Glatz JF, and Pelsers MA
- Subjects
- Adult, Aged, Aged, 80 and over, Alzheimer Disease blood, Alzheimer Disease diagnosis, Biomarkers blood, Carrier Proteins biosynthesis, Cognition Disorders blood, Cognition Disorders diagnosis, Dementia diagnosis, Fatty Acid Binding Protein 3, Fatty Acid-Binding Protein 7, Fatty Acid-Binding Proteins biosynthesis, Female, Humans, Male, Middle Aged, Parkinson Disease blood, Parkinson Disease diagnosis, Tumor Suppressor Proteins biosynthesis, Carrier Proteins blood, Dementia blood, Fatty Acid-Binding Proteins blood, Tumor Suppressor Proteins blood, Up-Regulation physiology
- Abstract
Background: There is a need for biomarkers in accessible matrices, such as blood, for the diagnosis of neurodegenerative diseases. The aim of this study was to measure the serum levels of brain-type fatty acid-binding protein (FABP) and heart-type FABP in patients with dementia-involving diseases., Methods: Brain- and heart-type FABP were measured in serum samples from patients with either Alzheimer's disease (AD) (n = 31), Parkinson's disease (PD, n = 43), or other cognitive disorders (OCD, n = 42) and in 52 healthy controls. The localization of brain- and heart-type FABP was determined in brain sections by immunohistochemistry., Results: Brain-type FABP levels were elevated in serum of 29%, 35%, and 24% of the patients with AD, PD, and OCD, respectively, and in 2% of the healthy donors. Heart-type FABP serum levels were not different amongst the patient groups. Brain-type and heart-type FABP expression was observed in reactive astrocytes in brain sections of patients with AD., Conclusions: In contrast to heart-type FABP, serum levels of brain-type FABP are elevated in a significant proportion of patients with various neurodegenerative diseases and can therefore have importance for defining subgroups of these patients., (© 2010 The Author(s). European Journal of Neurology © 2010 EFNS.)
- Published
- 2011
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