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Pancreatoblastoma is an uncommon pediatric neoplasm with distinct acinar and squamoid cell differentiation. This tumor often contains neuroendocrine and/or mesenchymal components. Pancreatoblastoma is exceedingly rare in adults, with only eight cases described (Table 1). We report a 68-yr-old white female with adult pancreatoblastoma, the oldest patient, to date, diagnosed with this unusual malignancy. [ABSTRACT FROM AUTHOR]

Focuses on several case reports of large inflammatory cloacogenic polyps. Details of the case reports; Area of the anus that develops inflammatory cloacogenic polyps; Common manifestation of inflammatory cloacogenic polyps; Possible key pathogenic element responsible for the condition.

Presents letters to the editor referencing articles and topics discussed in previous issues. "Diminutive Colonic Polyps: Histopathology, Spatial Distribution, Concomitant Significant Lesions, and Treatment Complications," which examined colonic polyps; "Small Colorectal Polyps: Histopathology and Clinical Significance," which analyzed colorectal polyps.

Abstract: Metanephric adenoma is a benign renal neoplasm with morphologic features similar to those of malignant renal neoplasms, such as papillary renal cell carcinoma (RCC) and Wilms’ tumor. Different methods have been used to distinguish between metanephric adenoma and papillary RCC and Wilms’ tumor. However, some techniques are not always available, such as certain immunohistochemical stains, cytogenetics, molecular genetics, and electron microscopy. In the current study, we compared the expression of S100 protein in 15 cases of metanephric adenoma, 10 cases of Wilms’ tumor, and 13 cases of papillary RCC. Our results revealed strong expression of S100 proteins in all cases of metanephric adenoma, weak expression in two cases of Wilms’ tumor, and no expression in any of the cases of papillary RCC. These findings indicate that S100 could be a useful and accessible tool for the diagnosis of metanephric adenoma. [Copyright &y& Elsevier]

Epidemiological studies have shown that consumption of red meat increases the risk of developing colon cancer. An enzyme, α-methylacyl CoA racemase (AMACR), also known as P504S, plays an important role in peroxisomal β-oxidation of branched-chain fatty acids from red meat and dairy products. High expression of AMACR was recently found in prostate cancer. In this study, we investigated expression of AMACR in 242 cases of colonic tumors including 176 colorectal carcinomas, 38 colon adenomas and 28 hyperplastic (non-neoplastic) polyps by immunohistochemical analysis. The mRNA levels of AMACR expression in normal and colon cancer tissues were assessed by real-time PCR. Significant up-regulation of AMACR mRNA was found in colon carcinomas compared to normal tissue. There was very low or no expression of AMACR protein in normal colon, but AMACR was highly expressed in 76 and 75% of well and moderately differentiated colon carcinomas, respectively, and in 79% of adenomas. In contrast, only 4% of hyperplastic polyps expressed AMACR. Since this enzyme is involved in the metabolism of branched-chain fatty acids from beef, milk and dairy products, our results provide important molecular information regarding a possible link between diet and development of colon cancer. AMACR may also serve as a molecular marker for colon cancers and its precursor lesions. [Copyright &y& Elsevier]