8 results on '"Biasco, Guido"'
Search Results
2. Retroperitoneal lymphangioma: A report of 2 cases and a review of the literature regarding the differential diagnoses of retroperitoneal cystic masses.
- Author
-
DI MARCO, MARIA CRISTINA, GRASSI, ELISA, VECCHIARELLI, SILVIA, DURANTE, SANDRA, MACCHINI, MARINA, and BIASCO, GUIDO
- Subjects
RETROPERITONEUM ,ABDOMINAL pain ,HISTOLOGY ,COMPUTED tomography ,TUMORS - Abstract
Cystic lymphangioma is a type of benign tumor originating from the lymph vessels. The tumor commonly occurs in childhood, in the head or neck regions, and retroperitoneal localization and presentations in adulthood are rare. Determining a pre-operative diagnosis is often challenging, and in the majority of cases, a diagnosis is only possible subsequent to the histological examination of the surgical specimen. A radical resection is the recommended treatment for cystic lymphangioma, and recurrence is usually due to an incomplete excision of the mass. The present study reports 2 cases of cystic lymphangioma, localized in the pancreatic gland and duodenal wall respectively, which were treated with surgical resection. The study also briefly reviews the literature regarding the differential diagnosis of retroperitoneal cystic masses. retroperitoneal or mesenteric sites, and pancreatic local- ization is rare. They are usually symptomatic and found accidentally (2). In symptomatic cases, the clinical presentation includes abdominal pain and distension. Symptoms may rarely be associated with complications, including intracystic bleeding, infection, cyst rupture or compression of adjacent organs (3). Diagnostic techniques include computed tomography (CT), magnetic resonance imaging (MRI) and endoscopic ultrasound with cyst fluid fine-needle aspiration, however, a definitive diagnosis of cystic lymphangioma is typically achieved by histological examination subsequent to surgery or exploratory laparotomy (3). Radical surgery is the recommended treatment for abdominal lymphangiomas, therefore, recurrence is rare and usually occurs due to an incomplete resection. Conservative methods, including aspi- ration, cyst enterostomy and peritoneal marsupialization, are now obsolete due to the high rate of recurrence (2). The present study reports 2 cases of retroperitoneal cystic lymphangioma that were treated by radical surgical resection and briefly reviews the literature regarding the differential diagnoses of retroperitoneal cystic masses. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
3. The ‘surprise’ question in advanced cancer patients: A prospective study among general practitioners.
- Author
-
Moroni, Matteo, Zocchi, Donato, Bolognesi, Deborah, Abernethy, Amy, Rondelli, Roberto, Savorani, Giandomenico, Salera, Marcello, Dall’Olio, Filippo G, Galli, Giulia, and Biasco, Guido
- Subjects
TUMOR prognosis ,CONFIDENCE intervals ,FISHER exact test ,LONGITUDINAL method ,GENERAL practitioners ,PROBABILITY theory ,STATISTICAL sampling ,STATISTICAL hypothesis testing ,STATISTICS ,T-test (Statistics) ,TUMORS ,TUMOR classification ,DATA analysis ,PROPORTIONAL hazards models ,DATA analysis software ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,ODDS ratio ,PSYCHOLOGY - Abstract
The article presents a study aimed to identified the prognostic accuracy by the general practitioners asking "surprise" questions about their patients. The study is conducted through a prospective cohort method on 42 of 50 randomly select general practitioners in the Bologna area of Italy between December 2011 and February 2012. The results of the study show that when general practitioners use "surprise" questions particularly for patients with cancer, the survival prognosis was high.
- Published
- 2014
- Full Text
- View/download PDF
4. Surgical second-look in high risk gastrointestinal stromal tumor of small intestine: A case report.
- Author
-
Nannini, Margherita, Pantaleo, Maria Abbondanza, Catena, Fausto, Romano, Stefania, Tondo, Salvatore, Pirini, Maria Giulia, Lolli, Cristian, Maleddu, Alessandra, Mandrioli, Anna, Gatto, Lidia, Saponara, Maristella, Pallotti, Maria Caterina, Dei Tos, Angelo Paolo, Pinna, Antonio Daniele, and Biasco, Guido
- Subjects
REOPERATION ,GASTROINTESTINAL stromal tumors ,SMALL intestine ,GASTROINTESTINAL tumors ,METASTASIS ,PERITONEAL cancer ,CASE studies ,TUMORS ,TUMOR risk factors - Abstract
Abstract: INTRODUCTION: The peritoneum is one of the most common sites of distant gastrointestinal stromal tumor (GIST) metastases. In particular, GIST arising from the small intestine with resected minimal synchronous macroscopic peritoneal carcinomatosis or with primary tumor rupture has a higher risk of developing peritoneal recurrence. Current clinical practice does not envisage second-look surgery in GIST patients at high risk of developing peritoneal recurrence, and no literature data are available. PRESENTATION OF CASE: We describe a 45-year-old woman who underwent emergency surgical resection of jejunal GIST presenting with spontaneous tumor rupture, synchronous ovarian and minimal macroscopic peritoneal involvement, and subsequent second-look surgery after 13 months of imatinib treatment. DISCUSSION: Second-look surgery confirmed a 2.6cm lesion close to the mesenteric border of the fourth jejunal loop, and 11 peritoneal lesions with a macroscopic necrotic aspect related to treatment response. After conversion to an open procedure, a segmental jejunal resection was performed with removal of all peritoneal lesions and macroscopic radical cytoreduction. CONCLUSION: Second-look surgery in selected GIST patients may be performed after at least 12 months of medical treatment with tyrosine-kinase inhibitors to identify those patients with limited peritoneal disease not disclosed by instrumental imaging who could undergo radical cytoreduction of peritoneal lesions. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
5. Evaluation of modified PEG-anilinoquinazoline derivatives as potential agents for EGFR imaging in cancer by small animal PET.
- Author
-
Pantaleo, Maria, Mishani, Eyal, Nanni, Cristina, Landuzzi, Lorena, Boschi, Stefano, Nicoletti, Giordano, Dissoki, Samar, Paterini, Paola, Piccaluga, Pier, Lodi, Filippo, Lollini, Pier-Luigi, Fanti, Stefano, Biasco, Guido, Pantaleo, Maria A, and Piccaluga, Pier Poalo
- Subjects
POLYETHYLENE glycol ,QUINAZOLINE ,EPIDERMAL growth factor ,CANCER diagnosis ,MEDICAL imaging systems ,MEDICAL polymers ,POSITRON emission tomography ,PROTEIN-tyrosine kinase inhibitors ,ANIMAL experimentation ,BIOLOGICAL models ,CELL lines ,COMPARATIVE studies ,DIAGNOSTIC imaging ,HETEROCYCLIC compounds ,RESEARCH methodology ,MEDICAL cooperation ,MICE ,MOLECULAR diagnosis ,MOLECULAR structure ,RESEARCH ,TUMORS ,EVALUATION research ,CONTRAST media ,PATHOLOGIC neovascularization ,METABOLISM - Abstract
Purpose: The in vivo evaluation of three modified polyethylene glycol (PEG)-anilinoquinazoline derivatives labeled with (124)I, (18)F, and (11)C as potential positron emission tomography (PET) bioprobes for visualizing epidermal growth factor receptor (EGFR) in cancer using small animal PET.Procedures: Xenograft mice with the human glioblastoma cell lines U138MG (lacking EGFR expression) and U87MG.wtEGFR (transfected with an overexpressing human wild-type EGFR gene) were used. Static and dynamic PET imaging was conducted for all three PEGylated compounds. Tumor necrosis, microvessel density, and EGFR levels were evaluated by histopathology and enzyme-linked immunosorbent assay.Results: Nineteen animal models were generated (two U138MG, three U87MG, 14 with both U138MG and U87MG bilateral masses). In static images, a slight increase in tracer uptake was observed in tumors, but in general, there was no retention of tracer uptake over time and no difference in uptake between U138MG and U87MG masses. In addition, no significant uptake was demonstrated in dynamic scans of the (18)F-PEG tracer. No necrosis was present except in four animals. MVD was 9.6 and 48 microvessels/×400 field in the U138GM and U87GM masses, respectively (p = 0.00008). Similarly, the microvessel grades were generally higher in the U87GM group (p = 0.002). Total EGFR amount was higher in U87MG than U138MG masses (p = 0.001), but the ratio of activated (pY1068) to total EGFR did not differ (p = 0.95).Conclusions: PEGylated tracers labeled with (11)C, (124)I, and (18)F showed no significant difference in uptake between U138MG and U87MG glioblastoma xenograft mice. The tracer binding with EGFR could be influenced by activation of the tyrosine kinase portion of the receptor which was similar in U138MG and U87MG. Despite these results, these tracers should be investigated in animal models with mutant EGFR genes to determine whether aberrant receptor function plays a role in tumor uptake. [ABSTRACT FROM AUTHOR]- Published
- 2010
- Full Text
- View/download PDF
6. Laparoscopic treatment of gastric GIST: report of 21 cases and literature's review.
- Author
-
Catena, Fausto, Di Battista, Monica, Fusaroli, Pietro, Ansaloni, Luca, Di Scioscio, Valerio, Santini, Donatella, Pantaleo, Maria, Biasco, Guido, Caletti, Giancarlo, and Pinna, Antonio
- Subjects
LAPAROSCOPIC surgery ,GASTROINTESTINAL tumors ,SURGICAL excision ,TUMORS ,HEMORRHAGE ,MORTALITY ,DISEASES ,LENGTH of stay in hospitals ,LAPAROSCOPY ,STAPLERS (Surgery) ,SUTURING ,TREATMENT effectiveness ,ENDOSCOPIC gastrointestinal surgery ,DIAGNOSIS - Abstract
Background: Although the feasibility of laparoscopic resection of gastric gastrointestinal stromal tumors (GISTs) has been established, various aspects are debated. This paper describes the problems of minimally invasive resection of gastric GISTs and compares this experience with an extensive literature review.Study Design: Between August 2001 and December 2006, 21 consecutive patients undergoing laparoscopic resection of gastric GISTs were enrolled in a prospective study. A literature review of laparoscopic treatment was performed on Pubmed using keywords GIST and surgery. A comparison with authors' experience with open wedge-segmental resection of GISTs (25 cases from November 1995 to December 2000) was also carried out. Statistical analysis was based on chi-squared test and t Student evaluation.Results: Twenty-one patients, mean age 50.1 years (range, 34-68 years), were submitted to laparoscopic wedge- segmental gastric resections. Mean tumor size was 4.5 cm (range, 2.0-8.5 cm). Mean operative time was 151 min (range, 52-310 min), the mean blood loss was 101 mL (range, 10-250 mL), and the mean hospital stay was 4.8 days (range 3-7 days). There were no major operative complications or mortalities. All lesions had negative resection margins. At a mean follow-up of 35 months, all patients were disease-free. Morbidity, mortality, length of stay, and oncologic outcomes were comparable to the open surgery retrospective evaluation (p=not significant).Conclusions: As found also in the literature review, the laparoscopic resection is safe and effective in treating gastric GISTs. Given these findings as well as the advantages afforded by laparoscopic surgery, a minimally invasive approach should be the preferred surgical treatment in patients with small- and medium-sized gastric GISTs. [ABSTRACT FROM AUTHOR]- Published
- 2008
- Full Text
- View/download PDF
7. Spontaneous Regression of a Desmoid Intraabdominal Tumor in a Patient Affected by Familial Adenomatous Polyposis.
- Author
-
Biasco, Guido, Pantaleo, Maria Abbondanza, Nobili, Elisabetta, and Monti, Carlo
- Subjects
- *
TUMORS , *DIGESTIVE system diseases , *LETTERS to the editor - Abstract
Presents a letter to the editor about spontaneous regression of a desmoid intraabdominal tumor in a patient affected by familial adenomatous polyposis, published in the 2004 issue of the "American Journal of Gastroenterology."
- Published
- 2004
- Full Text
- View/download PDF
8. Genetic Factors Associated With Pain Severity, Daily Opioid Dose Requirement, and Pain Response Among Advanced Cancer Patients Receiving Supportive Care.
- Author
-
Yennurajalingam, Sriram, Astolfi, Annalisa, Indio, Valentina, Beccaro, Monica, Schipani, Angela, Yu, Robert, Shete, Sanjay, Reyes-Gibby, Cielito, Lu, Zhanni, Williams, Janet L., Yeun, Sai-Ching, Anderson, Aimee E., Biasco, Guido, and Bruera, Eduardo
- Subjects
- *
DRUG dosage , *PAIN medicine , *ONCOLOGY , *CANCER patient care , *GENETIC testing , *PAIN management , *CANCER patients , *STAT proteins , *PHENOTYPES , *THERAPEUTIC use of narcotics , *RESEARCH , *PAIN , *ANALGESICS , *RESEARCH methodology , *GENETIC polymorphisms , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *TUMORS , *LONGITUDINAL method , *DISEASE complications - Abstract
Background: Current understanding of genetic factors associated with pain severity, and improvement of pain with opioids in advanced cancer patients (AC) is inadequate for delivery of personalized pain therapy (PPT). Therefore, the aim of this study was to determine the genetic factors associated with pain severity, daily opioid dose, and pain response in AC patients receiving supportive care.Methods: In this prospective study, AC patients were eligible if they had cancer pain ≥4/10 on Edmonton Symptom Assessment Scale (ESAS) - Pain Item and needed opioid rotation for pain control by specialist at the outpatient supportive care center. Association of genetic factors with pain phenotype was assessed using logistic regression models and SKATO (Gene-block) analysis.Results: About 174/178 (98%) patient samples were analyzed. After adjustment for demographic and clinical variables, pain severity was negatively associated with intron variant alleles in OPRM1 rs9322446, P = 0.02; rs2270459, P = 0.038; rs62052210, P = 0.038. Opioid daily dose was positively associated NFKBIA rs2233419, P = 0.008; rs2233417, P = 0.007; rs3138054, P = 0.008; rs1050851, P = 0.015; ORPM1 rs9479759, P = 0.046; rs2003185, P = 0.047; rs636433, P = 0.044; COMT (rs9306234, P = 0.014; rs165728, P = 0.014; rs2020917, P = 0.036; rs165728, P = 0.034); ARRB2 (rs1045280, P = 0.045); and pain response to opioids was negatively associated OPRM1 rs1319339, P = 0.024; rs34427887, P = 0.048; and COMT rs4646316, P = 0.03; rs35478083, P = 0.028, respectively. SKATO analysis showed association between pain severity and CXCL8 (P = 0.0056), and STAT6 (P = 0.0297) genes respectively, and pain response with IL-6 (P = 0.00499).Conclusions: This study identified that SNPs of OPRM1, COMT, NFKBIA, CXCL8, IL-6, STAT6, and ARRB2 genes were associated with pain severity, opioid daily dose, and pain response in AC receiving supportive care. Additional studies are needed to validate our findings for PPT. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.