Search

The present work investigated the effect of Partridge tea polyphenols (PTP) on streptozotocin (STZ)‑induced diabetic mice as well as the underlying mechanism with rosiglitazone as positive control. Administration with PTP (250 or 500 mg/kg) for 5 weeks, compared to the diabetic nephropathy control group (DC group), PTP significantly decreased the renal index, creatinine in serum and urine, urea nitrogen and proteinuria and alleviated histopathological injury of renal tissue. The levels of TNF-α, IL-1β and IL-6 were decreased and SOD, CAT activities were increased by PTP. PTP significantly reduced the FN and COL-IV levels. Moreover, PTP significantly inhibited the Keap1 mRNA level of Keap1 and the corresponding protein expression, while increased the mRNA levels of Nrf2, HO-1, NQO1 and the corresponding protein expression. Therefore, PTP could reverse renal injury, enhance renal functions, inhibit renal oxidative stress, and activate Keap1/Nrf2/ARE signaling pathway to alleviative diabetic nephropathy.

Coconut milk is an unstable emulsion system, mainly stabilized by proteins, which limits the development of the food industry. The aim of this study was to investigate mechanisms for increasing emulsion stability through the interaction between coffee polyphenols (CPs) and coconut globulin (CG), the main protein in coconut milk. Caffeic acid (CA), chlorogenic acid (CHA), and ferulic acid (FA) were selected as CP models. The results showed that hydrogen bond interactions mainly occurred between CG and CPs (CG-FA

Arecanut (Areca catechu L.) is one of the most important industrial crops in tropical Asia and parts of east Africa. However, the arecanut industry has suffered pandemic loss caused by negative reports such as carcinogenic effect. The healthy development of arecanut industry is of great significance. Our previous study found that arecanut (Areca catechu L.) seed polyphenol (ACP) can increase bone mass in ovariectomized rats which is closely related to metabolism of tryptophan. Here, we investigated the relationship among ACP, bone metabolism and serum metabolism in ovariectomized osteoporosis rat. We observed the bone structure of femur and analyzed the LDL-receptor relater protein 5 (LRP5), 5-hydroxytryptophan initial synthetase enzyme 1 (Tph1) and gut-derived serotonin (5-HT) in the gut, bone alkaline phosphatase (BALP), osteocalcin (OCN), Runt-related transcription factor 2 (RUNX2), osteoprotegerin (OPG) and receptor activator of nuclear factor NF-κB ligand (RANKL) in serum, 5-hydroxytryptophan receptor protein (Htr1b), bone morphogenetic protein-2 (BMP2) and β-catenin expression in bone and serum metabolites. The results indicated that compared with osteoporosis rats, ACP significantly improved the damaged bone structure, increased the ratio of OPG/RANKL, Lrp5, BMP2 and β-catenin. The ACP and E2 remarkably enhanced the expression of the metabolites such as 7-Ketodeoxycholic acid, indole and 15-Deoxy-Δ12, 14-prostaglandin, which were deeply linked with 5-HT synthesis via Lrp5 and tryptophan metabolism. Altogether, these studies shown that the ACP could downregulate 5-HT, which were implicated in serum metabolism and promoted bone mass by controlling the bone resorption and formation.