1. Fatty liver index is a risk determinant of incident type 2 diabetes in a metabolically healthy population with obesity.
- Author
-
Jung, Chang Hee, Kang, Yu Mi, Jang, Jung Eun, Hwang, Jenie Yoonoo, Kim, Eun Hee, Park, Joong ‐ Yeol, Kim, Hong ‐ Kyu, and Lee, Woo Je
- Subjects
FATTY liver ,TYPE 2 diabetes ,OBESITY ,TRIGLYCERIDES ,BODY mass index ,DISEASE risk factors - Abstract
Objective: This study investigated the effect of fatty liver disease (FLD) on the risk of incident type 2 diabetes in a population with metabolically healthy obesity (MHO).Methods: The study population comprised 34,258 Koreans without type 2 diabetes. Participants were stratified by BMI (cutoff value, 25.0 kg/m(2) ) and metabolic health state (using Wildman criteria). FLD was defined by the fatty liver index (FLI), a predictive algorithm to detect FLD. Subjects were classified into low and high FLI groups based on tertile.Results: At baseline, there were significant differences in FLI between four study groups. During a median follow-up of 36.5 months, 1.7% individuals developed type 2 diabetes. The risk of incident type 2 diabetes varied for the MHO group according to the level of FLI. The risk of type 2 diabetes in the MHO with low FLI was not significantly elevated compared with the metabolically healthy individuals without obesity (MHNO) with low FLI (multivariate-adjusted HR, 1.19 [95% CI 0.66-2.14]). However, the MHO with high FLI had an elevated risk of incident type 2 diabetes (multivariate-adjusted HR, 1.99 [95% CI 1.36-2.92]).Conclusions: MHO subjects have a substantially higher risk of incident type 2 diabetes than MHNO subjects. The presence of FLD assessed by FLI partially explains this increased risk. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF