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Your search keyword '"Seferović-Mitrović Jelena P."' showing total 2 results
Start Over Author "Seferović-Mitrović Jelena P." Topic type 2 diabetes
2 results on '"Seferović-Mitrović Jelena P."'

2. Ischemic stroke in patients with type 2 diabetes: Relationship between decreased insulin sensitivity and fibrinolysis impairment

Author

Jotić Aleksandra, Lalić Nebojša M., Čovičković-Šternić Nadežda, Kostić Vladimir, Lalić Katarina, Miličić Tanja, Mijailović Milija, Lukić Ljiljana, Rajković Nataša, Maćešić Marija, Aleksić Sandra, Seferović-Mitrović Jelena, Stošić Ljubica, and Zamaklar Miroslava

Subjects
ischemic stroke, type 2 diabetes, insulin sensitivity, plasminogen activator inhibitor-i (pai-i), Medicine
Abstract

The role of insulin sensitivity (IS), as well as the association of IS with fibrinolysis impairment, in the occurrence of ischemic stroke, has not been clarified. The study was aimed to analyze IS, plasma insulin (PI) and plasminogen activator inhibitor (PAI)-1 levels in 34 type 2 diabetics (T2D) with ischemic stroke (group A), 30 T2D without ischemic stroke (group B), 33 nondiabetics with ischemic stroke (group C) and 33 healthy controls (group D). Ischemic stroke was confirmed by clinical and neuroimaging criteria. IS levels were determined by the minimal model analysis (Si index). Plasma insulin levels were measured by radioimmunoassay and PAI-1 activity was performed by the plasminogen chromogenic plasmin substrate assay. We found that Silevels were significantly lower in group A vs. B (1.17+/-0.66 vs. 2.79+/-0.62 min-1/mU/Lx104; p

Published
2011
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