5 results on '"Jung, Ernst Michael"'
Search Results
2. Parametric Imaging of Contrast-Enhanced Ultrasound (CEUS) for the Evaluation of Acute Gastrointestinal Graft-Versus-Host Disease
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Wertheimer, Tobias, Pausch, Antonia-Maria, Kammerer, Sylvia, Weber, Florian, Herr, Wolfgang, Stroszczynski, Christian, Holler, Ernst, Edinger, Matthias, Wolff, Daniel, Weber, Daniela, and Jung, Ernst-Michael
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Adult ,Male ,GvHD ,ddc:610 ,QH301-705.5 ,610 Medizin ,Contrast Media ,Graft vs Host Disease ,Middle Aged ,CEUS ,parametric imaging ,allogeneic stem cell transplantation ,dynamic vascularization ,Article ,Postoperative Complications ,Elasticity Imaging Techniques ,Humans ,Transplantation, Homologous ,Female ,Biology (General) ,Digestive System Surgical Procedures ,Aged ,Stem Cell Transplantation ,Ultrasonography - Abstract
In recent years contrast-enhanced ultrasound (CEUS) has been an emerging diagnostic modality for the detection of acute gastrointestinal (GI) graft-versus-host disease (GvHD) in patients after allogeneic stem cell transplantation. However, broad clinical usage has been partially limited by its high dependence on the expertise of an experienced examiner. Thus, the aim of this study was to facilitate detection of acute GI GvHD by implementing false color-coded parametric imaging of CEUS. As such, two inexperienced examiners with basic knowledge in abdominal and vascular ultrasound analyzed parametric images obtained from patients with clinical suspicion for acute GvHD in a blinded fashion. As diagnostic gold standard, histopathological GvHD severity score on intestinal biopsies obtained from lower GI tract endoscopy was performed. The evaluation of parametric images by the two inexperienced ultrasound examiners in patients with histological confirmation of acute GI GvHD was successful in 17 out of 19 patients (89%) as opposed to analysis of combined B-mode ultrasound, strain elastography, and CEUS by an experienced examiner, which was successful in 18 out of 19 of the patients (95%). Therefore, CEUS with parametric imaging of the intestine was technically feasible and has the potential to become a valuable diagnostic tool for rapid and widely accessible detection of acute GvHD in clinical practice.
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- 2021
3. Color coded perfusion imaging with contrast enhanced ultrasound (CEUS) for post-interventional success control following trans-arterial chemoembolization (TACE) of hepatocellular carcinoma
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Rennert, Janine, Wiesinger, Isabel, Schicho, Andreas, Beyer, Lukas Philip, Wiggermann, Philipp, Stroszczynski, Christian, and Jung, Ernst Michael
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Male ,Cancer Treatment ,610 Medizin ,Contrast Media ,Pathology and Laboratory Medicine ,Diagnostic Radiology ,Ultrasound Imaging ,Image Processing, Computer-Assisted ,Medicine and Health Sciences ,Tomography ,Ultrasonography ,Aged, 80 and over ,ddc:610 ,Radiology and Imaging ,Liver Diseases ,Liver Neoplasms ,Middle Aged ,Magnetic Resonance Imaging ,Perfusion ,Liver ,Oncology ,Medicine ,Female ,Research Article ,Adult ,Carcinoma, Hepatocellular ,Imaging Techniques ,Science ,Perfusion Imaging ,Neuroimaging ,Surgical and Invasive Medical Procedures ,Gastroenterology and Hepatology ,Research and Analysis Methods ,Carcinomas ,Digestive System Procedures ,Signs and Symptoms ,Diagnostic Medicine ,Gastrointestinal Tumors ,Humans ,Chemoembolization, Therapeutic ,Aged ,Retrospective Studies ,Transplantation ,Microcirculation ,Cancers and Neoplasms ,Biology and Life Sciences ,Hepatocellular Carcinoma ,Organ Transplantation ,Computed Axial Tomography ,Liver Transplantation ,Lesions ,Gastrointestinal Imaging ,Liver and Spleen Scan ,Neuroscience - Abstract
AimEvaluation of an external color coded perfusion quantification software with CEUS for the post-interventional success control following TACE in patients with HCC.Material and methods31 patients (5 females, 26 males, age range 34-82 years, mean 66.8 years) with 59 HCC lesions underwent superselective TACE using DSM Beads between 01/2015 and 06/2018. All patients underwent CEUS by an experienced examiner using a convex multifrequency probe (1-6 MHz) within 24 hours following TACE to detect residual tumor tissue. Retrospective evaluation using a perfusion quantification software regarding pE, TTP, mTT, Ri and WiAUC in the center of the lesion, the margin and surrounding liver.ResultsIn all lesions, a post-interventional visual reduction of the tumor microvascularization was observed. Significant differences between center of the lesion vs. margin and surrounding liver were found regarding peak enhancement (867.8 ± 2416 center vs 2028 ± 3954 margin pConclusionCEUS with color- coded perfusion imaging is a valuable supporting tool for post-interventional success control following TACE of liver lesions. Peak enhancement seems to be the most valuable parameter.
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- 2019
4. Volume navigation with contrast enhanced ultrasound and image fusion for percutaneous interventions: first results
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Jung, Ernst Michael, Friedrich, Chris, Hoffstetter, Patrick, Dendl, Lena Marie, Klebl, Frank, Agha, Ayman, Wiggermann, Phillipp, Stroszczynski, Christian, and Schreyer, Andreas Georg
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Adult ,Male ,Adolescent ,Biopsy ,610 Medizin ,lcsh:Medicine ,Contrast Media ,Gastroenterology and Hepatology ,Diagnostic Radiology ,Diagnostic Medicine ,Computer Systems ,Pathology ,Humans ,Ultrasonics ,lcsh:Science ,Aged ,Ultrasonography ,ddc:610 ,Phantoms, Imaging ,Liver Diseases ,lcsh:R ,Biopsy, Needle ,Middle Aged ,Image Enhancement ,Magnetic Resonance Imaging ,Carcinoma, Intraductal, Noninfiltrating ,Catheter Ablation ,Medicine ,Feasibility Studies ,lcsh:Q ,Female ,Radiology ,Tomography, X-Ray Computed ,Research Article - Abstract
OBJECTIVE: Assessing the feasibility and efficiency of interventions using ultrasound (US) volume navigation (V Nav) with real time needle tracking and image fusion with contrast enhanced (ce) CT, MRI or US. METHODS: First an in vitro study on a liver phantom with CT data image fusion was performed, involving the puncture of a 10 mm lesion in a depth of 5 cm performed by 15 examiners with US guided freehand technique vs. V Nav for the purpose of time optimization. Then 23 patients underwent ultrasound-navigated biopsies or interventions using V Nav image fusion of live ultrasound with ceCT, ceMRI or CEUS, which were acquired before the intervention. A CEUS data set was acquired in all patients. Image fusion was established for CEUS and CT or CEUS and MRI using anatomical landmarks in the area of the targeted lesion. The definition of a virtual biopsy line with navigational axes targeting the lesion was achieved by the usage of sterile trocar with a magnetic sensor embedded in its distal tip employing a dedicated navigation software for real time needle tracking. RESULTS: The in vitro study showed significantly less time needed for the simulated interventions in all examiners when V Nav was used (p
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- 2012
5. Bedside diagnosis of pleural effusion with a latest generation hand-carried ultrasound device in intensive care patients
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Schleder, Stephan, Dornia, Christian, Poschenrieder, Florian, Dendl, Lena Marie, Cojocaru, L., Bein, Thomas, Schmid, Christof, Stroszczynski, Christian, Rennert, Janine, Jung, Ernst Michael, and Heiss, P.
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Thorax ,Adult ,Male ,medicine.medical_specialty ,Ultrasound device ,Pleural effusion ,Radiography ,Point-of-Care Systems ,Ultrasound, pleura, conventional radiography, thorax ,610 Medizin ,Sensitivity and Specificity ,Intensive care ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Ultrasonography ,Aged, 80 and over ,ddc:610 ,Radiological and Ultrasound Technology ,business.industry ,Ultrasound ,General Medicine ,Equipment Design ,Middle Aged ,medicine.disease ,Conventional radiography ,Pleural Effusion ,Intensive Care Units ,Hand carried ultrasound ,Female ,Radiography, Thoracic ,Radiology ,business - Abstract
Background Further development established hand-carried ultrasound (HCU) imagers in daily clinical workflow providing several advantages such as fast bedside availability and prompt diagnosis. Purpose To evaluate the diagnostic yield of a latest generation HCU imager compared to chest radiography (CR) for the detection of pleural effusion (PE) in intensive care patients. Material and Methods Forty-eight hemithoraces of 24 patients on surgical intensive care units were enrolled in this study. All hemithoraces were evaluated using both HCU and CR. Definite diagnosis of PE was achieved using a high-end ultrasound system as standard of reference. Statistical analysis was performed using 2 × 2 tables and a McNemar test. A P value of Results PE was present in 35 of 48 hemithoraces (73%). The HCU examination was carried out technically successfully in all hemithoraces. Sensitivity and specificity of HCU for the diagnosis of PE was 91% and 100%, respectively, whereas sensitivity and specificity of CR was 74% and 31%, respectively. The difference between HCU and CR was statistically significant with respect to specificity but not sensitivity ( P = 0.008 and P = 0.11, respectively). Conclusion Due to its ease of use and its high diagnostic yield HCU systems of the latest generation constitute a helpful technique for the primary assessment of PE.
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- 2012
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