1. Contrast-enhanced ultrasound Liver Imaging Reporting and Data System category M: a systematic review and meta-analysis
- Author
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Shin, Jaeseung, Lee, Sunyoung, Kim, Yeun-Yoon, Chung, Yong Eun, Choi, Jin-Young, and Park, Mi-Suk
- Subjects
medicine.medical_specialty ,liver neoplasms ,diagnosis ,ultrasound ,business.industry ,Ultrasound ,Washout ,microbubbles ,digestive system diseases ,Confidence interval ,sensitivity and specificity ,Meta-analysis ,Medical technology ,medicine ,Microbubbles ,Radiology, Nuclear Medicine and imaging ,Radiology ,R855-855.5 ,business ,neoplasms ,Meta-Analysis ,Arterial phase ,Contrast-enhanced ultrasound ,Liver imaging - Abstract
Purpose: A meta-analysis was conducted to determine the proportion of contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System category M (LR-M) in hepatocellular carcinomas (HCCs) and non-HCC malignancies and to investigate the frequency of individual CEUS LR-M imaging features.Methods: The MEDLINE and Embase databases were searched from January 1, 2016 to July 23, 2020 for studies reporting the proportion of CEUS LR-M in HCC and non-HCC malignancies. The meta-analytic pooled proportions of HCC and non-HCC malignancies in the CEUS LR-M category were calculated. The meta-analytic frequencies of CEUS LR-M imaging features in nonHCC malignancies were also determined. Risk of bias and applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.Results: Twelve studies reporting the diagnostic performance of the CEUS LR-M category were identified, as well as seven studies reporting the frequencies of individual CEUS LR-M imaging features. The pooled proportions of HCC and non-HCC malignancies in the CEUS LR-M category were 54% (95% confidence interval [CI], 44% to 65%) and 40% (95% CI, 28% to 53%), respectively. The pooled frequencies of individual CEUS LR-M imaging features in non-HCC malignancies were 30% (95% CI, 17% to 45%) for rim arterial phase hyperenhancement, 79% (95% CI, 66% to 90%) for early (
- Published
- 2022