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Objective: Hyperuricemia, which occurs as a result of high uric acid levels, the end product of purine metabolism, is related with asymptomatic hyperuricemia (ASH) when it does not show symptoms and gouty arthritis (GOUT) when urate crystals occur. Hyperuricemia may interact with metabolic syndrome components. Therefore, the aim of the study was to assess the relationship of GOUT and ASH with metabolic syndrome. Methods: The study was conducted with 145 individuals diagnosed with GOUT and ASH. Data on general characteristics, biochemical test results (serum fasting insulin, fasting blood glucose, uric acid, and blood lipids (such as low-density lipoprotein, total cholesterol, triglyceride, and high-density lipoprotein)), anthropometric (waist and hip circumferences, body weight and height) and blood pressure (systolic and diastolic) measurement results were collected. Bioelectrical Impedance Analysis was used to measure body composition. The National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) diagnostic criteria were used for the detection of metabolic syndrome. Written informed consent form was obtained from patients. Patients who were not volunteers, who were pregnant or lactating, diagnosed with cancer, chronic renal failure, chronic liver failure, and individuals using diuretic drugs were not included in the research. In the analyses of all hypothesis tests, p<0.05 was accepted significant. Results: The metabolic syndrome frequency was significantly higher in the GOUT group than in the ASH group (p<0.05). The difference between body mass index (BMI) values according to gender and groups was statistically significant among women (p<0.05). Mean body fat percentage values were significantly higher in women in both GOUT and ASH groups (p<0.05). Conclusion: The frequency of metabolic syndrome was significantly higher in the GOUT group. In addition, BMI and body fat percentage values were significantly higher in women. Abdominal obesity and possible hyperinsulinemia may cause more serious problems in the presence of hyperuricemia. Therefore, multiple parameters (various biochemical and anthropometric measurements) should be evaluated together. [ABSTRACT FROM AUTHOR]

Diet may play an important role in the development of asymptomatic hyperuricemia (ASH) and gouty arthritis (GOUT). However, the association between dietary factors and hyperuricemia remains unclear. Serum uric acid levels are affected by dietary factors. This study aimed to evaluate the correlation of uric acid levels with biochemical parameters and dietary factors in individuals with ASH and GOUT. This study was conducted in 145 individuals with ASH and GOUT. General characteristics of individuals were collected via face-to-face interviews. Food frequency questionnaire was used to obtain energy, macro- and micronutrients intakes. Biochemical parameters were obtained from patient files. The incidence of gout was higher in men comparing to women. Individuals in the GOUT group consumed more alcohol and higher serum levels of vitamin B12, C-reactive protein (CRP), triglyceride, and uric acid. Individuals in the GOUT group had higher intakes of energy, protein, carbohydrate, fat, fructose, vitamin C, and vitamin B12. Triglyceride, uric acid, CRP, vitamin B12, and homeostatic model assessment of insulin resistance were found to be affected by high uric acid levels. Dietary factors can pose a risk for health problems in addition to GOUT and ASH, such as cardiovascular disease, diabetes, and obesity. [ABSTRACT FROM AUTHOR]