6 results on '"Markhus, Maria"'
Search Results
2. Infant iodine status and associations with maternal iodine nutrition, breast-feeding status and thyroid function.
- Author
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Næss, Synnøve, Aakre, Inger, Strand, Tor A., Dahl, Lisbeth, Kjellevold, Marian, Stokland, Ann-Elin M., Nedrebø, Bjørn Gunnar, and Markhus, Maria Wik
- Subjects
THYROID gland physiology ,MOTHERS ,THYROID gland function tests ,LACTATION ,BREAST milk ,NUTRITIONAL requirements ,BREASTFEEDING ,IODINE ,SECONDARY analysis ,CHILDREN - Abstract
Adequate iodine nutrition during infancy is required for normal thyroid function and, subsequently, brain development. However, data on infant iodine status in the first year of life are scarce. This study aimed to describe infant iodine status and further explore its associations with maternal iodine nutrition, breast-feeding status and thyroid function. In this cohort study, 113 infants were followed up at ages 3, 6 and 11 months in Norway. Infant and maternal urinary iodine concentration (UIC), maternal iodine intake, breast milk iodine concentration (BMIC), breast-feeding status and infant thyroid function tests were measured. The median infant UIC was 82 µg/l at the age of 3 months and below the WHO cut-off of 100 µg/l. Infant UIC was adequate later in infancy (median 110 µg/l at ages 6 and 11 months). Infant UIC was associated positively with maternal UIC (β = 0·33, 95 % CI (0·12, 0·54)), maternal iodine intake (β = 0·30, 95 % CI (0·18, 0·42)) and BMIC (β = 0·46, 95 % CI (0·13, 0·79)). Breastfed infants had lower median UIC compared with formula-fed infants at ages 3 months (76 v. 190 µg/l) and 6 months (105 v. 315 µg/l). Neither infant UIC nor BMIC were associated with infant thyroid function tests. In conclusion, breastfed infants in Norway are at risk of insufficient iodine intake during the first months of life. Maternal iodine nutrition is important for providing sufficient iodine intake in infants, and awareness of promoting adequate iodine nutrition for lactating women should be prioritised. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Iodine status during pregnancy and at 6 weeks, 6, 12 and 18 months post‐partum.
- Author
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Aakre, Inger, Morseth, Marianne Sandsmark, Dahl, Lisbeth, Henjum, Sigrun, Kjellevold, Marian, Moe, Vibeke, Smith, Lars, and Markhus, Maria Wik
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CHILD development deviations -- Risk factors ,BREASTFEEDING ,CHILD health services ,CONFIDENCE intervals ,FOOD habits ,INFANT development ,INGESTION ,IODINE ,LONGITUDINAL method ,PREGNANCY complications ,PREGNANT women ,PRIMARY health care ,PUERPERIUM ,QUESTIONNAIRES ,REGRESSION analysis ,RESEARCH funding ,RISK assessment ,STATISTICS ,THYROID diseases ,URINALYSIS ,SECONDARY analysis ,BODY mass index ,DATA analysis software ,DESCRIPTIVE statistics ,IODINE deficiency ,ODDS ratio ,PREGNANCY outcomes ,DISEASE risk factors ,PREGNANCY - Abstract
Iodine deficiency during pregnancy and in the post‐partum period may lead to impaired child development. Our aim is to describe iodine status longitudinally in women from pregnancy until 18 months post‐partum. Furthermore, we explore whether iodine status is associated with dietary intake, iodine‐containing supplement use and breastfeeding status from pregnancy until 18 months post‐partum. We also assess the correlation between maternal iodine status 18 months post‐partum and child iodine status at 18 months of age. Iodine status was measured by urinary iodine concentration (UIC) during pregnancy (n = 1,004), 6 weeks post‐partum (n = 915), 6 months post‐partum (n = 849), 12 months post‐partum (n = 733) and 18 months post‐partum (n = 714). The toddlers' UIC was assessed at 18 months of age (n = 416). Demographic variables and dietary data (food frequency questionnaire) were collected during pregnancy, and dietary data and breastfeeding practices were collected at all time points post‐partum. We found that iodine status was insufficient in both pregnant and post‐partum women. The UIC was at its lowermost 6 weeks post‐partum and gradually improved with increasing time post‐partum. Intake of milk and use of iodine‐containing supplements significantly increased the odds of having a UIC above 100 μg/L. Neither the mothers' UIC, vegetarian practice, nor exclusion of milk and dairy products were associated with the toddlers UIC 18 months post‐partum. Women who exclude milk and dairy products from their diets and/or do not use iodine‐containing supplements may be at risk of iodine deficiency. The women possibly also have an increased risk of thyroid dysfunction and for conceiving children with nonoptimal developmental status. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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- View/download PDF
4. Sufficient iodine status among Norwegian toddlers 18 months of age -- cross-sectional data from the Little in Norway study.
- Author
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Aakre, Inger, Markhus, Maria Wik, Kjellevold, Marian, Dahl, Lisbeth, Moe, Vibeke, and Smith, Lars
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AGE distribution , *DIETARY supplements , *FOOD habits , *IODINE , *MASS spectrometry , *MILK , *NUTRITIONAL assessment , *NUTRITION policy , *NUTRITIONAL requirements , *QUESTIONNAIRES , *SEAFOOD , *DATA analysis , *CROSS-sectional method , *CHILDREN ,MALNUTRITION risk factors - Abstract
Background: Inadequate iodine intake has been identified in several population groups in the Nordic countries over the past years; however, studies of iodine status in infants and toddlers are scarce. Objective: The aim of this study is to evaluate the iodine status and dietary iodine sources among 18-monthold toddlers from Norway. Methods: Cross-sectional and country representative data from the Little in Norway study were used. All children who had given a spot urine sample at 18 months age were included (n = 416). Urinary iodine concentration (UIC) was determined by inductively coupled plasma mass-spectrometry. Dietary habits and supplement use were measured by a food frequency questionnaire. Results: Median (25th-75th percentiles [p25-p75]) UIC was 129 (81-190) µg/L while estimated median (p25-p75) habitual iodine intake was 109 (101-117) µg/day. None of the children were below the estimated average requirement (EAR) of 65 µg/day or above the upper intake level of 180 µg/day. There were no differences in either UIC or estimated habitual iodine intake between different geographic areas in Norway. Milk was the most important iodine source, contributing an estimated 70% to the total iodine intake, while other foods rich in iodine such as seafood and enriched baby porridge contributed about 30%. Conclusions: The iodine status among 18-month-old toddlers from different geographic areas in Norway was sufficient, indicated by a median UIC above the WHO cutoff of 100 µg/L. This was further supported by the estimated habitual iodine intake, where none of the participants were below the EAR. Milk was an important iodine source in this age group; thus children with a low intake might be at risk of insufficient iodine intake. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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5. Maternal Iodine Status is Associated with Offspring Language Skills in Infancy and Toddlerhood.
- Author
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Markhus, Maria Wik, Dahl, Lisbeth, Øyen, Jannike, Graff, Ingvild Eide, Kjellevold, Marian, Moe, Vibeke, Smith, Lars, Brantsæter, Anne Lise, Meltzer, Helle Margrete, Abel, Marianne Hope, and Stormark, Kjell Morten
- Abstract
Inadequate iodine status affects the synthesis of the thyroid hormones and may impair brain development in fetal life. The aim of this study was to explore the association between maternal iodine status in pregnancy measured by urinary iodine concentration (UIC) and child neurodevelopment at age 6, 12 and 18 months in a population-based cohort. In total, 1036 families from nine locations in Norway were enrolled in the little in Norway cohort. The present study includes n = 851 mother-child pairs with singleton pregnancies, no use of thyroid medication in pregnancy, no severe genetic disorder, data on exposure (UIC) in pregnancy and developmental outcomes (Bayley Scales of Infant and Toddler Development, third edition). Data collection also included general information from questionnaires. We examined associations between UIC (and use of iodine-containing supplements) and repeated measures of developmental outcomes using multivariable mixed models. The median UIC in pregnancy was 78 µg/L (IQR 46–130), classified as insufficient iodine intake according to the WHO. Eighteen percent reported use of iodine-containing multisupplements. A UIC below ~100 was associated with reduced receptive (p = 0.025) and expressive language skills (p = 0.002), but not with reduced cognitive or fine- and gross motor skills. Maternal use of iodine-containing supplements was associated with lower gross motor skills (b = −0.18, 95% CI = −0.33, −0.03, p = 0.02), but not with the other outcome measures. In conclusion, an insufficient iodine intake in pregnancy, reflected in a UIC below ~100 µg/L, was associated with lower infant language skills up to 18 months. The use of iodine-containing supplements was not associated with beneficial effects. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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6. Iodine Deficiency in a Study Population of Norwegian Pregnant Women—Results from the Little in Norway Study (LiN).
- Author
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Dahl, Lisbeth, Wik Markhus, Maria, Sanchez, Perla Vanessa Roldan, Moe, Vibeke, Smith, Lars, Meltzer, Helle Margrete, and Kjellevold, Marian
- Abstract
Iodine sufficiency is particularly important in pregnancy, where median urinary iodine concentration (UIC) in the range of 150–250 µg/L indicates adequate iodine status. The aims of this study were to determine UIC and assess if dietary and maternal characteristics influence the iodine status in pregnant Norwegian women. The study comprises a cross-sectional population-based prospective cohort of pregnant women (Little in Norway (LiN)). Median UIC in 954 urine samples was 85 µg/L and 78.4% of the samples (
n = 748) were ≤150 µg/L. 23.2% (n = 221) of the samples were ≤50 µg/L and 5.2% (n = 50) were above the requirements of iodine intake (>250 µg/L). Frequent iodine-supplement users (n = 144) had significantly higher UIC (120 µg/L) than non-frequent users (75 µg/L). Frequent milk and dairy product consumers (4–9 portions/day) had significantly higher UIC (99 µg/L) than women consuming 0–1 portion/day (57 µg/L) or 2–3 portions/day (83 µg/L). Women living in mid-Norway (n = 255) had lowest UIC (72 µg/L). In conclusion, this study shows that the diet of the pregnant women did not necessarily secure a sufficient iodine intake. There is an urgent need for public health strategies to secure adequate iodine nutrition among pregnant women in Norway. [ABSTRACT FROM AUTHOR]- Published
- 2018
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