1. [Phase II collaborative study of (2''R)-4'-0-tetrahydropyranyladriamycin (THP) for urological malignancies--Urological Co-operative THP Study Group].
- Author
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Niijima T, Koyanagi T, Sakashita S, Origasa S, Akaza H, Machida T, Koiso K, Rinsho K, Aso Y, and Suzuki K
- Subjects
- Adult, Aged, Alopecia chemically induced, Anorexia chemically induced, Carcinoma, Transitional Cell drug therapy, Doxorubicin administration & dosage, Doxorubicin adverse effects, Doxorubicin therapeutic use, Drug Administration Schedule, Drug Evaluation, Female, Humans, Infusions, Parenteral, Kidney Neoplasms drug therapy, Leukopenia chemically induced, Male, Middle Aged, Doxorubicin analogs & derivatives, Urinary Bladder Neoplasms drug therapy, Urologic Neoplasms drug therapy
- Abstract
A Phase II clinical trial of a new anthracycline, (2''R)-4'-0-tetrahydropyranyladriamycin (THP), was performed in 137 patients with urological malignancies. Out of them, 111 patients were evaluated for tumor responses and 125 patients were evaluated for adverse effects. In cases of intravenous administration, overall response rate was 18.5% (22.2% for bladder cancer, 30.0% for tumors of the renal pelvis and ureter, and 6.7% for prostatic cancer). In the case of intra-arterial administration, overall response rate was 42.9% (50.0% for bladder cancer). For 50 patients with superficial bladder cancer intravesical chemotherapy with THP was performed. Sixteen patients showed complete disappearance of the tumor, 2 patients showed more than 90% tumor regression and 12 patients showed more than 50% tumor regression, respectively. Overall response rate was 60%. Cardiotoxicity was minimal. Alopecia was noted in a total of 16 patients, but this was minimal. Leukocytopenia was the major adverse effect among patients undergoing systemic THP administration. In conclusion, THP was most effective against transitional cell carcinoma of the urinary tract.
- Published
- 1986