110 results on '"Daniela E. Andrich"'
Search Results
2. Single-stage tubular urethral reconstruction using oral grafts is an alternative to classical staged approach for selected penile urethral strictures
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Anthony R. Mundy, Mariya Dragova, Anastasia Frost, Felix Campos-Juanatey, Simon Bugeja, Stella L. Ivaz, and Daniela E. Andrich
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Male ,medicine.medical_specialty ,Urologic Surgical Procedures, Male ,Urethroplasty ,medicine.medical_treatment ,Urology ,030232 urology & nephrology ,Navicular fossa ,Invited Original Article ,anterior urethral stricture ,hypospadias ,lichen sclerosus ,oral mucosa ,reconstructive surgical procedures ,tissue transplants ,Lichen sclerosus ,Single Center ,lcsh:RC870-923 ,03 medical and health sciences ,0302 clinical medicine ,Urethra ,medicine ,Humans ,Stage (cooking) ,Retrospective Studies ,Urethral Stricture ,030219 obstetrics & reproductive medicine ,Single stage ,business.industry ,Mouth Mucosa ,General Medicine ,Plastic Surgery Procedures ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Urethra surgery ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Hypospadias ,business ,Penis - Abstract
Penile urethral strictures have been managed by a staged surgical approach. In selected cases, spongiofibrosis can be excised, a neo-urethral plate created using buccal mucosa graft (BMG) and tubularized during the same procedure, performing a “two-in-one” stage approach. We aim to identify stricture factors which indicate suitability for this two-in-one stage approach. We assess surgical outcome and compare with staged reconstruction. We conducted an observational descriptive study. The data were prospectively collected from two-in-one stage and staged penile urethroplasties using BMG in a single center between 2007 and 2017. The minimum follow-up was 6 months. Outcomes were assessed clinically, radiologically, and by flow-rate analysis. Failure was defined as recurrent stricture or any subsequent surgical or endoscopic intervention. Descriptive analysis of stricture characteristics and statistical comparison was made between groups. Of 425 penile urethroplasties, 139 met the inclusion criteria: 59 two-in-one stage and 80 staged. The mean stricture length was 2.8 cm (single stage) and 4.5 cm (staged). Etiology was lichen sclerosus (LS) 52.5% (single stage) and 73.8% hypospadias related (staged). 40.7% of patients had previous failed urethroplasties in the single-stage group and 81.2% in the staged. The most common stricture locations were navicular fossa (39.0%) and distal penile urethra (59.3%) in the single-stage group and mid or proximal penile urethra (58.7%) in the staged group. Success rates were 89.8% (single stage) and 81.3% (staged). A trend toward a single-stage approach for select penile urethral strictures was noted. We conclude that a single-stage substitution penile urethroplasty using BMG as a “two-in-one” approach is associated with excellent functional outcomes. The most suitable strictures for this approach are distal, primary, and LS-related strictures.
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- 2020
3. Syringoceles of Cowper's ducts and glands in adult men
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Daniela E Andrich, Stella Ivaz, Anthony R. Mundy, Anastasia Frost, Mariya Dragova, and Simon Bugeja
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Adult ,Male ,medicine.medical_specialty ,complications ,Urethral stricture ,Urology ,Urethroplasty ,medicine.medical_treatment ,030232 urology & nephrology ,Invited Original Article ,Pelvic Pain ,lcsh:RC870-923 ,Cowper's glands ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Lower urinary tract symptoms ,medicine ,Humans ,Urethral Stricture ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,treatment ,business.industry ,Magnetic resonance imaging ,General Medicine ,Syringocele ,Middle Aged ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Symptomatic relief ,Surgery ,Urethra ,medicine.anatomical_structure ,syringocele ,cowper's glands ,urethral stricture ,Bulbourethral Glands ,Cowper's ducts ,business - Abstract
Cowper's syringoceles are uncommon, usually described in children and most commonly limited to the ducts. We describe more complex variants in an adult population affecting with varying degrees of severity, the glands themselves, and the complications they may lead to. One hundred consecutive urethrograms of patients with unreconstructed strictures were reviewed. Twenty-six patients (mean age: 41.1 years) with Cowper's syringoceles who were managed between 2009 and 2016 were subsequently evaluated. Presentation, radiological appearance, treatment (when indicated), and outcomes were assessed. Of 100 urethrograms in patients with strictures, 33.0% demonstrated filling of Cowper's ducts or glands, occurring predominantly in patients with bulbar strictures. Only 1 of 26 patients with non-bulbar strictures had a visible duct/gland. Of 26 symptomatic patients, 15 presented with poor flow. In four patients, a grossly dilated Cowper's duct obstructed the urethra. In the remaining 11 patients, a bulbar stricture caused the symptoms and the syringocele was identified incidentally. Eight patients presented with perineal pain. In six of them, fluoroscopy and magnetic resonance imaging (MRI) revealed complex multicystic lesions within the bulbourethral glands. Four patients developed perineoscrotal abscesses. In the 11 patients with strictures, the syringocele was no longer visible after urethroplasty. In three of four patients with urethral obstruction secondary to a dilated Cowper's duct, this resolved after transperineal excision (n = 2) and endoscopic deroofing (n = 1). Five of six patients with complex syringoceles involving Cowper's glands were excised surgically with symptomatic relief in all. In conclusion, Cowper's syringocele in adults is more common than previously thought and may cause lower urinary tract symptoms or be associated with serious complications which usually require surgical treatment.
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- 2020
4. MP35-16 SURGICAL MANAGEMENT OF URETHRO-CUTANEOUS FISTULA ORIGINATING FROM THE ANTERIOR URETHRA IN ADULT MEN OVER A 10 YEAR PERIOD
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Angelica Lock, Daniela E. Andrich, Simon Bugeja, Anastasia Frost, Nikki Jeffery, Anthony R. Mundy, Stella Ivaz, and Mariya Dragova
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medicine.medical_specialty ,business.industry ,Urology ,Cutaneous fistula ,Fistula ,Medicine ,Anterior urethra ,Presentation (obstetrics) ,business ,medicine.disease ,Surgery - Abstract
INTRODUCTION AND OBJECTIVE:Urethro-cutaneous fistula (UCF) originating from the anterior urethra in adult men is an uncommon presentation. We describe our experience in managing this problem.METHOD...
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- 2020
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5. MP41-18 UROSYMPHYSEAL FISTULATION AFTER THE TREATMENT OF PROSTATE CANCER
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Nikki Jeffrey, Mariya Dragova, Daniela E. Andrich, Stella Ivaz, Angelica Lomiteng, Anastasia Frost, Anthony R. Mundy, and Simon Bugeja
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Oncology ,Prostate cancer ,medicine.medical_specialty ,business.industry ,Urology ,Internal medicine ,medicine ,medicine.disease ,business - Published
- 2020
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6. The Nontransecting Approach to Bulbar Urethroplasty
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Anastasia Frost, Stella Ivaz, Daniela E. Andrich, S. Bugeja, and Anthony R. Mundy
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Male ,medicine.medical_specialty ,Urologic Surgical Procedures, Male ,Urethral stricture ,Urology ,Urethroplasty ,medicine.medical_treatment ,030232 urology & nephrology ,03 medical and health sciences ,0302 clinical medicine ,Urethra ,medicine ,Humans ,Significant risk ,Urethral Stricture ,business.industry ,Primary anastomosis ,Standard treatment ,Anastomosis, Surgical ,Blood flow ,Plastic Surgery Procedures ,medicine.disease ,Surgery ,Sexual dysfunction ,Corpus Spongiosum ,030220 oncology & carcinogenesis ,medicine.symptom ,business - Abstract
The standard treatment of bulbar urethral strictures of appropriate length is excision and primary anastomosis (EPA), irrespective of the cause of the stricture. This involves transection of the corpus spongiosum (CS) and disruption of the blood flow within the CS as a consequence. The success rate of EPA in curing these strictures is very high, but there is a considerable body of evidence and of opinion to suggest that there is a significant risk of sexual dysfunction and, potentially, of other adverse consequences that occur because of transection of the CS.
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- 2017
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7. PD33-06 LONG-TERM EFFECT OF BLADDER AUGMENTATION ON RENAL FUNCTION
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Anthony R. Mundy, Nikki Jeffrey, Mariya Dragova, Angelica Lomiteng, Anastasia Frost, Daniela E. Andrich, Simon Bugeja, and Stella Ivaz
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medicine.medical_specialty ,Bladder augmentation ,business.industry ,Urology ,medicine ,Renal function ,Term effect ,business - Published
- 2019
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8. MP55-19 THE OUTOME OF REVISIONAL URETHROPLASTY SURGERY
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Simon Bugeja, Mariya Dragova, Nikki Jeffrey, Anastasia Frost, Anthony R. Mundy, Stella Ivaz, Angelica Lomiteng, and Daniela E. Andrich
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medicine.medical_specialty ,business.industry ,Urology ,Urethroplasty ,medicine.medical_treatment ,medicine ,In patient ,business ,Surgery - Abstract
INTRODUCTION AND OBJECTIVES:This study evaluates the outcome of redo-urethroplasty in patients with recurrent penile, bulbar or posterior urethral strictures with a particular view to identifying a...
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- 2019
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9. Long term continence rates in patients undergoing augmentation cystoplasty with 30 year follow up
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N. Jeffery, Daniela E. Andrich, S. Bugeja, Anthony R. Mundy, Anastasia Frost, J. Olphert, M. Dragova, A. Lomiteng, and Stella Ivaz
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medicine.medical_specialty ,business.industry ,Urology ,Medicine ,In patient ,business ,Augmentation cystoplasty ,Surgery ,Term (time) - Published
- 2021
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10. What constitutes complexity rather than difficulty in the surgical reconstruction of pelvic fracture-related urethral injuries?
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Anthony R. Mundy, J. Olphert, A. Lomiteng, N. Jeffery, Stella Ivaz, Anastasia Frost, M. Dragova, Daniela E. Andrich, and S. Bugeja
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medicine.medical_specialty ,business.industry ,Urology ,Pelvic fracture ,Medicine ,business ,medicine.disease ,Surgery - Published
- 2021
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11. Incidence of post-micturition dribble after bulbar urethroplasty using transecting and non-transecting approaches
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Anthony R. Mundy, J. Olphert, N. Jeffery, Anastasia Frost, A. Lomiteng, Daniela E. Andrich, S. Bugeja, Stella Ivaz, and M. Dragova
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medicine.medical_specialty ,business.industry ,Urology ,Urethroplasty ,medicine.medical_treatment ,Incidence (epidemiology) ,media_common.quotation_subject ,medicine ,business ,Urination ,Surgery ,media_common - Published
- 2021
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12. Non-transecting bulbar urethroplasty using buccal mucosa
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A.V. Frost, Daniela E. Andrich, S. Bugeja, Anthony R. Mundy, and Stella Ivaz
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Dorsum ,medicine.medical_specialty ,Urethral stricture ,Urology ,Urethroplasty ,medicine.medical_treatment ,030232 urology & nephrology ,Anastomosis ,lcsh:RC870-923 ,Buccal mucosa ,Bulbar urethroplasty ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Non-transecting ,Surgical treatment ,business.industry ,Buccal administration ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,Surgery ,surgical procedures, operative ,Mucosal graft ,030220 oncology & carcinogenesis ,Buccal mucosal graft ,business - Abstract
Augmentation urethroplasty using oral mucosal graft has become the standard surgical treatment of long bulbar strictures. In very tight strictures the urethral plate is narrowed to the extent that an almost circumferential substitution with oral graft is necessary, with suboptimal results. If the obliterative segment within a longer stricture is short it is possible, through a dorsal stricturotomy, to excise it in a non-transecting manner, leaving the ventral spongiosum intact and anastomose the mucosal edges to reconstitute the urethral plate to an adequate calibre. The stricturotomy is subsequently augmented with an oral mucosal graft. We describe this technique as the augmented non-transecting anastomotic bulbar urethroplasty. It also allows for use of a narrower and shorter graft. In our hands this procedure is associated with a 100% radiological success rate and a 95% patient satisfaction rate at a mean follow-up of 14.8 months (5.7–52.6 months). Keywords: Urethral stricture; Bulbar urethroplasty; Non-transecting; Buccal mucosal graft
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- 2016
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13. Fistulation into the Pubic Symphysis after Treatment of Prostate Cancer: An Important and Surgically Correctable Complication
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Daniela E. Andrich, S. Bugeja, and Anthony R. Mundy
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Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Brachytherapy ,030232 urology & nephrology ,Pubic symphysis ,Cryosurgery ,03 medical and health sciences ,Prostate cancer ,Postoperative Complications ,0302 clinical medicine ,Humans ,Medicine ,Prospective Studies ,External beam radiotherapy ,Aged ,Prostatectomy ,Osteitis pubis ,Groin ,Urinary Bladder Fistula ,business.industry ,Prostatic Neoplasms ,Pubic Symphysis ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,body regions ,Radiation therapy ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Urologic Surgical Procedures ,Chronic Pain ,business - Abstract
Chronic pubic pain after the treatment of prostate cancer is often attributed to osteitis pubis. We have become aware of another complication, namely fistulation into the pubic symphysis, which is more serious and more common than previously thought.A total of 16 patients were treated for urosymphyseal fistulas after the treatment of prostate cancer between January 2011 and April 2014. Clinical presentation was characterized by chronic, debilitating pubic/pelvic/groin pain in all patients. Diagnosis was confirmed by magnetic resonance imaging. Conservative management was successful in only 1 patient. The remaining patients were treated surgically with excision of the fistulous track and involved symphyseal bone and omentoplasty, followed by reconstruction when feasible.All 16 patients had had radiotherapy as primary treatment (8) or after prostatectomy (8). There were 5 patients (31.3%) who underwent various combinations of brachytherapy, external beam radiotherapy and cryotherapy. Bladder neck contractures developed in 13 patients (81.3%), whose treatment (endoscopic or open reconstruction) resulted in urinary leak leading to urosymphyseal fistulas. Reconstruction was possible in 7 of 15 patients (46.7%) with salvage radical prostatectomy and substitution/augmentation cystoplasty. The other 8 patients (53.3%) underwent cystectomy and ileal conduit diversion. All patients experienced resolution of symptoms, most significantly the almost immediate resolution of pain.A high index of suspicion must be maintained in irradiated patients presenting with symptoms suggestive of urosymphyseal fistulas, especially after having undergone treatment of bladder neck contractures or prostatic urethral stenoses. Although extensive, surgery for urosymphyseal fistulas, with a high risk of morbidity and mortality and a protracted recovery, leads to immediate and dramatic improvement in symptoms.
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- 2016
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14. MP35-02 IS URETHROPLASTY REALLY MORE COST-EFFECTIVE THAN URETHRAL DILATATION FOR PRIMARY BULBAR URETHRAL STRICTURES?
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Nikki Jeffrey, Anastasia Frost, Mariya Dragova, Stella Ivaz, Simon Bugeja, Daniela E. Andrich, Angelica Lomiteng, and Anthony R. Mundy
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medicine.medical_specialty ,business.industry ,Urology ,Urethroplasty ,medicine.medical_treatment ,medicine ,business ,Urethral dilatation ,Surgery - Published
- 2020
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15. PD37-05 IMPLANTATION OF AN ARTIFICIAL URINARY SPHINCTER (AUS) IN PATIENTS WITH BLADDER NECK CONTRACTURE (BNC) OR PROSTATIC STENOSIS (PS) MANAGED ENDOSCOPICALLY. IS IT SAFE?
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Anthony R. Mundy, Nikki Jeffrey, Simon Bugeja, Anastasia Frost, Stella Ivaz, Daniela E. Andrich, and Mariya Dragova
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Artificial urinary sphincter ,medicine.medical_specialty ,Stenosis ,business.industry ,Urology ,Bladder neck contracture ,Medicine ,In patient ,business ,medicine.disease ,Surgery - Published
- 2020
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16. Funneling of the bladder neck - radiological appearance after radical retropubic prostatectomy and clinical relevance
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Daniela E Andrich, Anthony R. Mundy, Anastasia Frost, Felix Campos, Stella Ivaz, and Simon Bugeja
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Male ,Prostatectomy ,medicine.medical_specialty ,business.industry ,Invited Opinion ,Urology ,medicine.medical_treatment ,General Medicine ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,Magnetic Resonance Imaging ,Urinary Bladder Neck Obstruction ,Neck of urinary bladder ,Radiological weapon ,Humans ,Medicine ,Clinical significance ,Radiology ,business ,Radical retropubic prostatectomy - Published
- 2020
17. MP25-03 PELVIC FRACTURE URETHRAL INJURY – THE NATURE OF THE CAUSATIVE INJURY CORRELATES STRONGLY WITH SURGICAL TREATMENT AND OUTCOME
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Stella Ivaz, Simon Bugeja, Anastasia Frost, Mariya Dragova, Daniela E. Andrich, and Anthony R. Mundy
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Urology - Published
- 2018
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18. PD30-08 EVALUATION OF PATIENT REPORTED OUTCOME METHODS (PROM) IN PATIENTS UNDERGOING DIFFERENT APPROACHES TO BULBAR URETHROPLASTY
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Simon Bugeja, Stella Ivaz, Anastasia Frost, Mariya Dragova, Felix Campos Juanatey, Daniela E. Andrich, and Anthony R. Mundy
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Urology - Published
- 2018
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19. PD43-11 THE LONG-TERM OUTCOMES OF AUGMENTATION CYSTOPLASTY AT 20-30 YEARS FOLLOW UP
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Daniela E. Andrich, Anastasia Frost, Mariya Dragova, Simon Bugeja, and Anthony R. Mundy
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medicine.medical_specialty ,business.industry ,Urology ,Long term outcomes ,Medicine ,business ,Augmentation cystoplasty ,Surgery - Published
- 2018
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20. PD63-05 BULBAR URETHRAL STRICTURES AFTER THE TREATMENT OF PROSTATE CANCER
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Mariya Dragova, Anastasia Frost, Daniela E. Andrich, Simon Bugeja, Stella Ivaz, and Anthony R. Mundy
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medicine.medical_specialty ,Prostate cancer ,business.industry ,Urology ,medicine ,medicine.disease ,business - Published
- 2018
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21. MP75-12 BLADDER NECK ARTIFICIAL URINARY SPHINCTER (BN AUS) FOR RECURRENT OR COMPLEX PRIMARY URODYNAMICALLY PROVEN STRESS AND MIXED URINARY INCONTINENCE – OUTCOMES FROM A TERTIARY REFERRAL CENTRE
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Dunia Benamer, Jeremy Ockrim, Daniela E. Andrich, Eabhann O'Connor, Tamsin Greenwell, and Anthony R. Mundy
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Artificial urinary sphincter ,Neck of urinary bladder ,Mixed urinary incontinence ,medicine.medical_specialty ,business.industry ,Urology ,Tertiary referral centre ,Medicine ,business - Published
- 2018
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22. PD43-07 MANAGEMENT OF URINARY/PERINEAL FISTULAE COMPLICATING THE MODERN TREATMENT OF RECTAL CANCER
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Daniela E. Andrich, Stella Ivaz, Anthony R. Mundy, Anastasia Frost, Simon Bugeja, and Mariya Dragova
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medicine.medical_specialty ,business.industry ,Colorectal cancer ,Urology ,Urinary system ,medicine ,business ,medicine.disease ,Surgery - Published
- 2018
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23. Urethral atrophy after implantation of an artificial urinary sphincter: fact or fiction?
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Daniela E. Andrich, Simon Bugeja, Anastasia Frost, Anthony R. Mundy, and Stella L. Ivaz
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Male ,Reoperation ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Urinary incontinence ,Balloon ,Artificial urinary sphincter ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Urethra ,Recurrence ,medicine ,Humans ,Intraoperative Care ,medicine.diagnostic_test ,business.industry ,Cystoscopy ,Middle Aged ,medicine.disease ,Prosthesis Failure ,Surgery ,Urinary Incontinence ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cuff ,Urinary Sphincter, Artificial ,Female ,medicine.symptom ,Abnormality ,business - Abstract
To investigate the concept of 'urethral atrophy', which is often cited as a cause of recurrent incontinence after initially successful implantation of an artificial urinary sphincter (AUS); and to investigate the specific cause of the malfunction of the AUS in these patients and address their management.Between January 2006 and May 2013, 50 consecutive patients (mean age 54.3 years) with recurrent incontinence had their AUS explored for malfunction and replaced with a new device with components of exactly the same size, unless there was a particular reason to use something different. Average time to replacement of the device was 10.1 years. The mean follow-up after replacement of the device was 24.7 months. All patients without an obvious cause for their recurrent incontinence had preoperative urodynamic evaluation, including measurement of the Valsalva leak point pressure (VLPP) and the retrograde cuff occlusion pressure (RCOP). After explantation of the AUS in patients without any apparent abnormality of the device at the time of replacement, the pressure generated by the explanted pressure-regulating balloon (PRB) was measured manometrically, when this was possible. In a select group of six consecutive patients of this type, the fibrous capsule surrounding the old cuff was incised then excised to expose and evaluate the underlying corpus spongiosum.In 31 of the 50 patients (62%) undergoing exploration, a specific cause for the malfunction of their AUS was defined. In the other 19 patients (38%) no cause was found, either preoperatively or at the time of exploration, other than a low VLPP and RCOP. A typical 'waisted' or 'hour-glass' appearance of the underlying corpus spongiosum was demonstrable, to some degree, on explanting the cuff in all cases. In the six patients in whom the restrictive sheath surrounding the cuff was excised, the urethral circumference immediately returned to normal after the compressive effect of the sheath was released. Manometry of the explanted PRBs, when this was possible, showed a loss of pressure in all instances. Replacement of the explanted AUS with a new device with the same size cuff and PRB in 14 of these 19 patients was successful in 12 (85.7%).These results, and other theoretical considerations, suggest that recurrent incontinence, years after initially successful implantation of an AUS, is because of material failure of the PRB, probably attributable to its age and consequent loss of its ability to generate the pressure it was designed to produce, and that urethral atrophy does not occur. Simply replacing the old device with a new one with the same characteristics, unless there is a particular reason to do otherwise, is usually successful and avoids the complications of alternatives such as as cuff downsizing, implanting a PRB with a higher pressure range, implantation of a second cuff or transcorporeal cuff placement, all of which have been advocated in these patients.
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- 2015
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24. Intermittent self-dilatation for urethral stricture disease in males: A systematic review and meta-analysis
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Daniela E. Andrich, Christopher Harding, Matthew Jackson, Anthony R. Mundy, Rajan Veeratterapillay, Trevor J. Dorkin, and Stella Ivaz
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medicine.medical_specialty ,Urethrotomy ,Urethral stricture ,business.industry ,Urology ,medicine.medical_treatment ,Urethroplasty ,030232 urology & nephrology ,medicine.disease ,law.invention ,Surgery ,03 medical and health sciences ,Catheter ,0302 clinical medicine ,Urethra ,medicine.anatomical_structure ,Randomized controlled trial ,Quality of life ,law ,030220 oncology & carcinogenesis ,Meta-analysis ,medicine ,Neurology (clinical) ,business - Abstract
Background Intermittent self-dilatation (ISD) may be recommended to reduce the risk of recurrent urethral stricture. Level one evidence to support the use of this intervention is lacking. Objectives Determine the clinical and cost-effectiveness of ISD for the management of urethral stricture disease in males. Search Methods The strategy developed for the Cochrane Incontinence Review Group as a whole (last searched May 7, 2014). Selection Criteria Randomised trials where one arm was a programme of ISD for urethral stricture. Data Collection and Analysis At least two independent review authors carried out trial assessment, selection, and data abstraction. Results Data from six trials that were pooled and collectively rated very low quality per the GRADE approach, indicated that recurrent urethral stricture was less likely in men who performed ISD than those who did not (RR 0.70, 95% CI 0.48–1.00). Two trials compared programmes of ISD but the data were not combined and neither were sufficiently robust to draw firm conclusions. Three trials compared devices for performing ISD, results from one of which were too uncertain to determine the effects of a low friction hydrophilic catheter versus a polyvinyl chloride catheter on risk of recurrent urethral stricture (RR 0.32, 95% CI 0.07 to 1.40); another did not find evidence of a difference between 1% triamcinolone gel for lubricating the ISD catheter versus water-based gel on risk of recurrent urethral stricture (RR 0.68, 95% CI 0.35 to 1.32). No trials gave cost-effectiveness or validated PRO data. Conclusions ISD may decrease the risk of recurrent urethral stricture. A well-designed RCT is required to determine whether that benefit alone is sufficient to make this intervention worthwhile and in whom. Neurourol. Urodynam. 35:759–763, 2016. © 2015 Wiley Periodicals, Inc.
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- 2015
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25. PD64-10 LONG TERM OUTCOME FOLLOWING BLADDER NECK ARTIFICIAL URINARY SPHINCTER IMPLANTATION
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Simon Bugeja, Stella Ivaz, Stacey Frost, Mariya Dragova, Daniela E Andrich, and Anthony R Mundy
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Urology - Published
- 2017
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26. PD34-02 HE LONG-TERM RESULTS OF NON-TRANSECTING BULBAR URETHROPLASTY
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Stella Ivaz, Stacey Frost, Anthony R. Mundy, Mariya Dragova, Daniela E. Andrich, and Simon Bugeja
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medicine.medical_specialty ,business.industry ,Urology ,Urethroplasty ,medicine.medical_treatment ,medicine ,Long term results ,business ,Surgery - Published
- 2017
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27. MP24-16 UROSYMPHYSEAL FISTULATION - WHAT'S IN A NAME?
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Daniela E. Andrich, Stacey Frost, Simon Bugeja, Stella Ivaz, Anthony R. Mundy, and Mariya Dragova
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Urology ,030232 urology & nephrology ,Medicine ,business ,Classics - Published
- 2017
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28. V1-08 SURGICAL CORRECTION OF URORECTAL FISTULA (URF) FOLLOWING RADICAL PROSTATECTOMY FOR THE TREATMENT OF PROSTATE CANCER
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Anthony R. Mundy, Enrique Fes Ascanio, Daniela E. Andrich, Felix Campos Juanatey, Simon Bugeja, Stella Ivaz, and Anastasia Frost
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medicine.medical_specialty ,Prostate cancer ,business.industry ,Prostatectomy ,Urology ,Fistula ,medicine.medical_treatment ,medicine ,Surgical correction ,medicine.disease ,business - Published
- 2017
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29. PD38-12 THE EFFECT OF RADIOTHERAPY ON THE OUTCOME OF THE REPAIR OF URORECTAL FISTULAE
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Daniela E. Andrich, Simon Bugeja, Anthony R. Mundy, Stella Ivaz, Mariya Dragova, and Stacey Frost
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Radiation therapy ,medicine.medical_specialty ,business.industry ,Urology ,medicine.medical_treatment ,medicine ,business ,Outcome (game theory) ,Surgery - Published
- 2017
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30. SIU/ICUD Consultation on Urethral Strictures: The Management of Anterior Urethral Stricture Disease Using Substitution Urethroplasty
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Andre G. Cavalcanti, Anthony Atala, Yosuke Nakajima, Guido Barbagli, Daniela E. Andrich, Christopher R. Chapple, Altaf Mangera, and Sanjay Kulkarni
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Male ,medicine.medical_specialty ,Consensus ,Urethral stricture ,Urology ,Urethroplasty ,medicine.medical_treatment ,MEDLINE ,Context (language use) ,Surgical Flaps ,Postoperative Complications ,Patient Education as Topic ,Urethra ,Recurrence ,medicine ,Humans ,Urethrostomy ,Urethral Stricture ,Tissue Engineering ,medicine.diagnostic_test ,business.industry ,Mouth Mucosa ,Plastic Surgery Procedures ,medicine.disease ,Endoscopy ,Review article ,Surgery ,medicine.anatomical_structure ,business - Abstract
In this systematic review of the literature, a search of the PubMed database was conducted to identify articles dealing with augmentation/substitution urethral reconstruction of the anterior urethral stricture. The evidence was categorized by stricture site, surgical technique, and the type of tissue used. The committee appointed by the International Consultation on Urological Disease reviewed this data and produced a consensus statement relating to the augmentation and substitution of the anterior urethra. In this review article, the background pathophysiology is discussed. Most cases of urethral stricture disease in the anterior urethra are consequent on an ischemic spongiofibrosis. The choice of technique and the surgical approach are discussed along with the potential pros and cons of the use of a graft vs a flap. There is research potential for tissue engineering. The efficacy of the surgical approach to the urethra is reviewed. Whenever possible, a 1-stage approach is preferable from the patient's perspective. In some cases, with complex penile urethral strictures, a 2-stage procedure might be appropriate, and there is an important potential role for the use of a perineal urethrostomy in cases where there is an extensive anterior urethral stricture or where the patient does not wish to undergo complex surgery, or medical contraindications make this hazardous. It is important to have accurate outcome measures for the follow-up of patients, and in this context, a full account needs to be taken of patients' perspectives by the use of appropriate patient-reported outcome measures. The use of symptoms and a flow rate can be misleading. It is well established that with a normally functioning bladder, the flow rate does not diminish until the caliber of the urethra falls below 10F. The most accurate means of following up patients after stricture surgery are by the use of endoscopy or visualization by urethrography. Careful consideration needs to be made of the outcomes reported in the world literature, bearing in mind these aforementioned points. The article concludes with an overview of the key recommendations provided by the committee.
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- 2014
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31. A new bacterial resistant polymer catheter coating to reduce catheter associated urinary tract infection (CAUTI): A first-in-man pilot study
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A. Frost, K. Kalenderski, B. Macrae, Jean-Frédéric Dubern, Anthony R. Mundy, A. Lomiteng, Daniela E. Andrich, M. Dragova, Paul Williams, Morgan R. Alexander, and N. Jeffery
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Catheter ,medicine.medical_specialty ,Coating ,business.industry ,Urology ,engineering ,Medicine ,engineering.material ,business ,Catheter-associated urinary tract infection ,Surgery - Published
- 2019
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32. Rectourethral Fistulas Secondary to Prostate Cancer Treatment: Management and Outcomes from a Multi-Institutional Combined Experience
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Daniela E. Andrich, Gerald H. Jordan, Anthony R. Mundy, Catherine R. Harris, Jack W. McAninch, Alex J. Vanni, Benjamin N. Breyer, Ramón Virasoro, and Leonard Zinman
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Male ,high-intensity focused ultrasound ablation ,Urinary Fistula ,Fistula ,medicine.medical_treatment ,030232 urology & nephrology ,prostatic neoplasms ,California ,Cohort Studies ,Hospitals, University ,Prostate cancer ,0302 clinical medicine ,Postoperative Complications ,Prostatectomy ,Urology & Nephrology ,Middle Aged ,Hospitals ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,Reoperation ,Reconstructive surgery ,medicine.medical_specialty ,Urology ,Clinical Sciences ,Rectourethral fistula ,Risk Assessment ,03 medical and health sciences ,medicine ,fistula ,Humans ,Rectal Fistula ,Reconstructive Surgical Procedures ,Aged ,Retrospective Studies ,University ,prostatectomy ,Radiotherapy ,business.industry ,Prostatic Neoplasms ,Recovery of Function ,Plastic Surgery Procedures ,medicine.disease ,High-intensity focused ultrasound ,Surgery ,Urethra ,Quality of Life ,urethra ,Complication ,business ,Follow-Up Studies - Abstract
PurposeRectourethral fistula is a known complication of prostate cancer treatment. Reports in the literature on rectourethral fistula repair technique and outcomes are limited to single institution series. We examined the variations in technique and outcomes of rectourethral fistula repair in a multi-institutional setting.Materials and methodsWe retrospectively identified patients who underwent rectourethral fistula repair after prostate cancer treatment at 1 of 4 large volume reconstructive urology centers, including University of California-San Francisco, University College London Hospitals, Lahey Clinic and Devine-Jordan Center for Reconstructive Surgery, in a 15-year period. We examined the types of prostate cancer treatment, technical aspects of rectourethral fistula repair and outcomes.ResultsAfter prostate cancer treatment 201 patients underwent rectourethral fistula repair. The fistula developed in 97 men (48.2%) after radical prostatectomy alone and in 104 (51.8%) who received a form of energy ablation. In the ablation group 84% of patients underwent bowel diversion before rectourethral fistula repair compared to 65% in the prostatectomy group. An interposition flap or graft was placed in 91% and 92% of the 2 groups, respectively. Concomitant bladder neck contracture or urethral stricture developed in 26% of patients in the ablation group and in 14% in the prostatectomy group. Postoperatively the rates of urinary incontinence and complications were higher in the energy ablation group at 35% and 25% vs 16% and 11%, respectively. The ultimate success rate of fistula repair in the energy ablation and radical prostatectomy groups was 87% and 99% with 92% overall success.ConclusionsRectourethral fistulas due to prostate cancer therapy can be reconstructed successfully in a high percent of patients. This avoids permanent urinary diversion in these complex cases.
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- 2016
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33. PD44-06 WHAT CONSTITUTES COMPLEXITY IN THE SURGICAL RECONSTRUCTION OF PELVIC FRACTURE-RELATED URETHRAL INJURIES?
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Daniela E. Andrich, Anastasia Frost, Enrique Fes, Anthony R. Mundy, Simon Bugeja, Felix Campos, and Stella Ivaz
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medicine.medical_specialty ,Degloving ,Urethrotomy ,business.industry ,Urology ,Osteomyelitis ,medicine.medical_treatment ,Anastomosis ,medicine.disease ,Surgery ,Neck of urinary bladder ,Urethra ,medicine.anatomical_structure ,Pelvic ring ,medicine ,Pelvic fracture ,business - Abstract
INTRODUCTION AND OBJECTIVES: Bulbo-prostatic anastomotic urethroplasty (BPA) for urethral injuries associated with traumatic disruption of the pelvic ring is notoriously a surgical challenge, often requiring various manouvres to straighten the course of the bulbar urethra and bridge the resulting defect. There are however other factors which may render the reconstructive procedure more complex. This study investigates these factors. METHODS: 360 BPAs were performed in a single tertiary referral centre between October 1996 and October 2014. 77 (21%) were revision procedures. Mean patient age was 37.9 years. Mean follow-up was 51 months (range 9-115 months). Recurrence was defined radiologically and/or by the need for any further surgical intervention including dilatation or urethrotomy. RESULTS: 286 (79%) procedures were carried out transperineally (Step 1-4) while 74 (21%) required additional abdominal exposure to mobilise the bladder bladder base (n1⁄416), repair associated injuries (n1⁄441) or perform an entero-urethroplasty (n1⁄417). 29 of 74 (39%) abdomino-perineal (AP) procedures were revisions. 48 of 77 revisions (62%) were performed via a transperineal approach. The restricture rate was higher for revision procedures compared to primary ones when approached transperineally (15% vs 8%) but not for AP procedures (21% in both primary and revision cases). Overall, the recurrence rate for AP procedures was 21% compared to 9% for the transperineal approach. Associated bladder neck injury (n1⁄418), uro-rectal/perineal fistulae (n1⁄415), perineal degloving injury (n1⁄46), anterior urethral stricture (n1⁄419) and osteomyelitis/pelvic sepsis (n1⁄410) were identified as factors adding complexity to the procedure. CONCLUSIONS: A longer defect and revisional surgery often require corporal separation, inferior wedge pubectomy and rerouting of the urethra around the crura in a stepwise fashion in order to guarantee a tension-free anastomosis. These render the procedure more difficult but do not necessarily imply increasing complexity. Factors necessitating a change in approach (usually but not exclusively requiring additional abdominal exposure) to deal with multiple pathologies such as the need for bladder neck reconstruction or concominant anterior urethral strictures are what render the procedure complex.
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- 2016
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34. PD49-09 MANAGEMENT OF SPHINCTER WEAKNESS INCONTINENCE (SWI) IN PATIENTS WITH CONCOMITANT BLADDER NECK CONTRACTURES (BNC) AFTER THE TREATMENT OF PROSTATE CANCER
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Anastasia Frost, Daniela E. Andrich, Stella Ivaz, Simon Bugeja, Anthony R. Mundy, Felix Campos, and Enrique Fes
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medicine.medical_specialty ,Weakness ,business.industry ,Urology ,medicine.disease ,Surgery ,Neck of urinary bladder ,Prostate cancer ,medicine.anatomical_structure ,Concomitant ,Medicine ,Sphincter ,In patient ,medicine.symptom ,business ,Muscle contracture - Published
- 2016
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35. Posterior urethral complications of the treatment of prostate cancer
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Anthony R. Mundy and Daniela E. Andrich
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Reconstructive surgery ,medicine.medical_specialty ,Urethral stricture ,business.industry ,Prostatectomy ,Urology ,medicine.medical_treatment ,Brachytherapy ,Cryotherapy ,medicine.disease ,Surgery ,Neck of urinary bladder ,Urethra ,medicine.anatomical_structure ,medicine ,External beam radiotherapy ,business - Abstract
What's known on the subject? and What does the study add? Urethral strictures, bladder neck and posterior urethral contractures, and urorectal fistulation are three well-recognised complications of the treatment of prostate cancer, whether by surgery or non-surgical treatment. Because these are relatively rare problems the treatment is uncertain. There is a heavy reliance on endoscopic or instrumental management of urethral strictures and of bladder neck and posterior urethral contractures, and there is little discrimination in any of these conditions between those that are the result of surgery and those that are the result of radiotherapy and other treatment methods using external energy sources. This review aims to clarify out current understanding of these three clinical problems and draws attention to the role of reconstructive surgery, particularly when dealing with bladder neck contractures, prostatic urethral stenoses and urorectal fistula. This also shows that the nature of the problem, the recovery time after treatment and the degree of functional recovery is radically different in the surgical as against the non-surgical group, to a degree that the authors believe is not sufficiently stressed when patients are counselled and consented before their primary treatment. • To review the less common and not widely discussed, but much more serious complications of prostate cancer treatment of: urethral stricture, bladder neck contracture and urorectal fistula. • The treatment options for patients with organ-confirmed prostate cancer include: radical prostatectomy (RP), brachytherapy (BT), external beam radiotherapy (EBRT), high-intensity focussed ultrasound (HIFU) and cryotherapy; with each method or combination of methods having associated complications. • Complications resulting from RP are relatively easy to manage, with rapid recovery and return to normal activities, and usually a return to normal bodily functions. • However, after non-surgical treatments, i.e. BT, EBRT, HIFU and cryotherapy, these same problems are more difficult to treat with a much slower return to a much lower level of function. • When counselling patients about the primary treatment of prostate cancer they should be advised that although the same type of complication may occur after surgical or non-surgical treatment, the scope and scale of that complication, the ease with which it is treated and the degree of restoration of normality after treatment, is altogether in favour of surgery in those for whom surgery is appropriate and who are fit for surgery.
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- 2012
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36. Non-transecting anastomotic bulbar urethroplasty: a preliminary report
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Anthony R. Mundy and Daniela E. Andrich
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medicine.medical_specialty ,Urethral stricture ,business.industry ,Urology ,Urethroplasty ,medicine.medical_treatment ,Anastomosis ,medicine.disease ,Surgery ,Corpus Spongiosum ,Preliminary report ,medicine ,Anastomotic urethroplasty ,Blood supply ,business ,Bulbar urethral stricture - Abstract
Objective To report our early experience with a novel approach to the excision and end-to-end anastomotic repair of bulbar urethral strictures. Patients and methods A total of 22 patients underwent excision and end-to-end anastomosis of a proximal bulbar urethral stricture using a technique in which the corpus spongiosum is not transected, so as to maintain its blood supply intact. The range of follow-up was 6-21 months and for 16 patients the follow up was ≥1 year. Results At 1 year of follow-up there was no evidence of a recurrent stricture on symptomatic assessment or uroflowmetry in the 16 patients. On urethrography one patient has a urethral calibre 80% of normal. In the other 15 the calibre is normal or greater than normal. Conclusion The non-transecting anastomotic bulbar urethroplasty technique used appears to give results that are as good as those of traditional anastomotic urethroplasty with less surgical trauma.
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- 2011
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37. Urethral trauma. Part II: Types of injury and their management
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Anthony R. Mundy and Daniela E. Andrich
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medicine.medical_specialty ,business.industry ,Urology ,General surgery ,Human factors and ergonomics ,Poison control ,Suicide prevention ,Urethra surgery ,Occupational safety and health ,Urethra ,medicine.anatomical_structure ,Injury prevention ,medicine ,Physical therapy ,business ,Cohort study - Abstract
What’s known on the subject? and What does the study add? Iatrogenic trauma aside, urethral injuries are not common. Nonetheless, there have been a large number of cohort studies, generally of small numbers of patients. This review pulls together all of the information available to try and produce a coherent narrative.
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- 2011
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38. Urethral trauma. Part I: introduction, history, anatomy, pathology, assessment and emergency management
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Anthony R. Mundy and Daniela E. Andrich
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Pathology ,medicine.medical_specialty ,Urethra ,medicine.anatomical_structure ,Emergency management ,business.industry ,Urology ,MEDLINE ,Medicine ,Narrative ,business ,Urethra surgery ,Cohort study - Abstract
What’s known on the subject? and What does the study add? Iatrogenic trauma aside, urethral injuries are not common. Nonetheless, there have been a large number of cohort studies, generally of small numbers of patients. This review pulls together all of the information available to try and produce a coherent narrative.
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- 2011
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39. Urethral strictures
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Anthony R. Mundy and Daniela E. Andrich
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medicine.medical_specialty ,business.industry ,Urology ,medicine ,business ,Surgery - Published
- 2010
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40. Urorectal fistulae following the treatment of prostate cancer
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Anthony R. Mundy and Daniela E. Andrich
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medicine.medical_specialty ,business.industry ,Prostatectomy ,Urology ,medicine.medical_treatment ,Brachytherapy ,Colostomy ,Cryotherapy ,medicine.disease ,Surgery ,Artificial urinary sphincter ,Radiation therapy ,Prostate cancer ,Colon surgery ,Medicine ,business - Abstract
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? It is known that urorectal fistulae is a serious but rare complication of the treatment of carcinoma of the prostate. This study adds a distinction between post-surgical fistulate and post-irradiation fistulae. Essentially most post-surgical fistulae are simple and relatively easily dealt with: the expectation is that the patient will return to normality; whereas post-irradiation fistulate are by their nature complex and much more difficult to treat with a much more uncertain long-term outcome. Complexity is discussed and defined. OBJECTIVE • To evaluate the management of urorectal fistulae (URF) in light of new technology in prostate cancer treatment, which has changed the nature of these URF and, therefore, the approach to treatment. PATIENTS AND METHODS • Between 2004 and 2009 we repaired URF after treatment for prostate cancer in 40 patients with a minimum of 1-year follow-up since their last intervention. • In 23 patients (post-surgical group) the URF resulted from open, laparoscopic or robotic radical prostatectomy. In the other 17 patients (post-irradiation group) the URF resulted from either external beam radiation (EBRT) or brachytherapy (BT), or both, salvage cryotherapy or salvage high-intensity focused ultrasound (sHIFU). • In the 23 patients in the post-surgical group a transperineal repair was performed. In the post-irradiation group a transperineal repair was performed in three of the 17 patients. A transabdominal or abdominoperineal repair was performed in the remaining 14 patients, combined with salvage radical prostatectomy in those eight patients in whom a discrete prostate still existed, and in whom this was possible. RESULTS • The URF were cured in all patients. • A bladder-neck contracture (BNC) developed in two patients, one of whom is being managed by interval dilatation and the other of whom had a revision of his vesico-urethral anastomosis. Sphincter weakness incontinence required further treatment in eight patients by implantation of an artificial urinary sphincter. • A specific category of complex URF with cavitation was identified, which is particularly common after sHIFU following the combination of previous EBRT and BT, but which may result from the sequential application of any ‘new technology’. CONCLUSIONS • URF of any degree of complexity can be managed without the need for a transanorectal sphincter-splitting approach or a covering colostomy and without the need for an interposition flap when the circumstances are appropriate and the surgeon is sufficiently experienced. URF with cavitation and in the post-irradiation group are an exception and do require an interposition flap. • The role of salvage radical prostatectomy in patients with a URF who still have a prostate, needs to be defined. • We suggest that cavitation, BNC and extensive ischaemia due to the serial application of external energy sources confer ‘complexity’. Post-surgical URF are simple except for those with cavitation or a BNC. Most post-irradiation URF are complex even in the absence of cavitation or a BNC.
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- 2010
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41. Pelvic fracture-related injuries of the bladder neck and prostate: their nature, cause and management
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Daniela E. Andrich and Anthony R. Mundy
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Adult ,Male ,medicine.medical_specialty ,Urologic Surgical Procedures, Male ,Urinary Incontinence, Stress ,Urology ,medicine.medical_treatment ,Urinary Bladder ,Urinary incontinence ,urologic and male genital diseases ,Urinary catheterization ,Artificial urinary sphincter ,Fractures, Bone ,Young Adult ,Urethra ,Prostatic urethra ,Mitrofanoff procedure ,Humans ,Medicine ,Pelvic Bones ,Rupture ,business.industry ,Prostate ,Middle Aged ,female genital diseases and pregnancy complications ,Surgery ,Neck of urinary bladder ,Treatment Outcome ,medicine.anatomical_structure ,Urinary Tract Infections ,Prostate surgery ,medicine.symptom ,Urinary Catheterization ,business - Abstract
OBJECTIVE To report our experience of bladder neck injuries, which are a well recognized but rare consequence of pelvic fracture-related trauma to the lower urinary tract, as we have been unable to find any reference in the English literature to their specific nature, cause and management in adults. PATIENTS AND METHODS In the last 10 years we have treated 15 men with bladder neck injuries after pelvic fracture. Two were treated at our centre by delayed primary repair. Thirteen were initially treated elsewhere and presented to us 3 months to 5 years after their injury with intractable incontinence and various other symptoms most notably recurrent urinary infection and gross haematuria. Twelve of the injuries were at or close to the anterior midline and associated with lateral compression fractures or 'open-book' injuries. Five of them were confined to the bladder neck and prostatic urethra; the other seven extended into the subprostatic urethra. Four of these were associated with a coincidental typical rupture of the posterior urethra. All had an associated cavity involving the anterior disruption of the pelvic ring. Two of the injuries, following particularly severe trauma, were a simultaneous complete transection of the bladder neck and of the bulbo-membranous urethra with a sequestered prostate between. We have seen this in children before but not in adults. Another injury, also after particularly severe trauma, was an avulsion of the anterior aspect of the prostate. We have not seen this described before. Fourteen patients underwent lower urinary tract reconstruction and one underwent a Mitrofanoff procedure. All of the 14 had a layered reconstruction of the prostate and bladder neck and in 13, this was supplemented with an omental wrap. RESULTS In all patients with an anterior midline rupture, the primary injury appeared to be to the prostate and prostatic urethra with secondary involvement of the bladder neck and the subprostatic urethra. The Mitrofanoff procedure was successful. Of the 14 patients with a layered reconstruction one, without an omental wrap, broke down but was successfully repaired on a subsequent occasion. The four patients who also had a ruptured urethra had a simultaneous bulbo-prostatic anastomotic urethroplasty, two of which required further attention. Eight of the 14 reconstructed patients underwent implantation of an artificial urinary sphincter (AUS) for sphincter weakness incontinence, in seven of whom this was successful. Two of these had previously undergone implantation of an AUS with an unsatisfactory outcome and were made continent by bladder neck reconstruction. The other six patients had acceptable urinary incontinence by reconstruction of the bladder neck and urethra alone. CONCLUSIONS The primary injury is to the prostate and prostatic urethra. The bladder neck and subprostatic urethra are involved secondarily by extension. These injuries have a particular cause and a particular location with a predictable outcome. They need to be identified and treated promptly as they do not heal spontaneously and otherwise cause considerable morbidity. We also describe two particular types of bladder neck injury that we have not seen described before in adults.
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- 2010
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42. Entero-urethroplasty for the salvage of bulbo-membranous stricture disease or trauma
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Anthony R. Mundy and Daniela E. Andrich
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medicine.medical_specialty ,Urethral stricture ,business.industry ,Urology ,Urethroplasty ,medicine.medical_treatment ,Sigmoid colon ,Ileum ,Anastomosis ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Urethra ,Prostate ,medicine ,business ,Superior pubic ramus - Abstract
Study Type – Therapy (case series) Level of Evidence 4 OBJECTIVE To describe a salvage procedure for bulbo-membranous stricture disease or trauma. PATIENTS AND METHODS Over a 10-year period 11 patients with otherwise unsalvageable strictures of the bulbo-membranous urethra or defects after trauma were treated by interposition of a tailored intestinal flap. An intestinal flap, on average 8 cm in length, was harvested from the ileum, the stomach, the right colon or (preferably) the sigmoid colon, and tailored to a calibre of 26–30 F. It was then sutured between the stump of the prostate and the distal bulbar or proximal pendulous urethra either following the normal perineal route for the urethra or a more direct route through a trench cut in the superior pubic ramus. RESULTS Three patients developed proximal anastomotic contractures requiring interval dilatation in one and revision in two. Two patients developed a stone in the gut segment one of which was removed traumatically causing irreparable damage to the neourethra. The results were otherwise satisfactory. CONCLUSION For an otherwise unsalvageable bulbo-membranous stricture or defect, a tailored flap of intestine, preferably sigmoid colon, gives satisfactory results. Of the two potential routes for the neourethra, we have more experience with the normal route but the direct route has several advantages.
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- 2009
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43. A Fellowship programme in reconstructive urological surgery: what is it and what is it for?
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Anthony R. Mundy and Daniela E. Andrich
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medicine.medical_specialty ,genetic structures ,business.industry ,Trainer ,Urology ,General surgery ,education ,Surgical procedures ,Urological surgery ,Reconstructive urology ,Surgery ,medicine ,Complication rate ,business ,Logbook ,Fellowship training - Abstract
OBJECTIVE To report our experience of a 3-year Fellowship in reconstructive urology for its content and duration, with particular reference to what can be achieved each year. METHODS Over the 3-year period October 2004 to October 2007 the Fellow worked full-time in a specialist reconstructive urological centre as principal assistant to the trainer in the care of outpatients and inpatients, and in the performance of the various surgical procedures. Using a prospectively constructed logbook it was possible to compare the developing surgical experience of the Fellow in terms of both the frequency and complexity of the cases undertaken and the surgical outcomes, compared with similar data for the trainer. RESULTS Over the 3-year period the Fellow progressively took on more cases and of increasing complexity, and the trainer progressively adopted the role of assistant, except for particularly complex cases. Throughout this period the complication rate of the trainer and the Fellow remained the same. CONCLUSIONS Even at the end of 3 years the Fellow was still limited in what she could deal with as an independent practitioner. Fellowship training should be goal directed in content and duration, and based around hands-on experience.
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- 2009
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44. Proposed mechanisms of lower urinary tract injury in fractures of the pelvic ring
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Daniela E. Andrich, Adrian C. Day, and Anthony R. Mundy
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urology ,Radiography ,Urinary system ,Fractures, Bone ,Pelvic ring ,medicine ,Humans ,Pelvic Bones ,Urinary Tract ,Aged ,business.industry ,Acetabular fracture ,Soft tissue ,Acetabulum ,Middle Aged ,Pelvic cavity ,medicine.disease ,Surgery ,Neck of urinary bladder ,medicine.anatomical_structure ,Pelvic fracture ,Female ,business - Abstract
OBJECTIVE To investigate whether the observation of particular pelvic fracture patterns enables the clinician to predict the presence and type of injuries to the lower urinary tract, as the mechanisms of injury to the lower urinary tract in association with fractures of the pelvic ring are unclear. PATIENTS AND METHODS The case-notes and radiographs of 168 patients with either pelvic ring or acetabular fractures were reviewed; 108 pelvic ring fractures (81 men, 27 women) and 60 acetabular fractures (46 men, 14 women). The pelvic fractures were classified according to the system described by Tile and were correlated with the incidence and type of lower urinary tract injury (LUTI). RESULTS Overall, of the 108 men and women with pelvic ring fractures, 27 (25%) had a LUTI documented either radiologically or as an intraoperative finding. Of the 81 men with pelvic ring fractures, 24 (30%) had a LUTI, of whom six (7%) had an isolated bladder laceration, 14 (17%) a partial urethral injury (PUI) and four (5%) a complete urethral disruption (CUD). Five of the 18 men with urethral injuries also had bladder injuries and in three of these, the bladder neck was also injured. Three of 27 women (11%) had a LUTI, all of whom had isolated bladder lacerations. Of the 46 men with an acetabular fracture, one (2%) had a CUD, and three (7%) had a PUI. One of 14 of women with an acetabular fracture sustained a bladder laceration. None of the three men with a Tile Type-A pelvic ring fracture sustained a LUTI. Of the 28 men with 'open-book' (Tile Type-B1) fractures, 21 (75%) had no associated LUTI and seven (25%) had a LUTI (five partial urethral injuries and two bladder lacerations). Of the 10 men with 'lateral compression' (Tile Type-B2) fractures, six had no LUTI and four had a LUTI (two partial urethral injuries and two bladder lacerations). Of the 40 men with 'vertical shear' (Tile Type-C) fractures, 27 (68%) had no LUTI and 13 (32%) a LUTI (four complete urethral disruptions, seven partial urethral injuries, and two bladder lacerations) including all of the combined bladder and urethral injuries and all of the bladder neck injuries. CONCLUSION The pelvic fracture pattern alone does not predict the presence of a LUTI. When it occurs, the type of LUTI appears to be related to the fracture mechanism. The pattern of injury to the soft tissue envelope and specifically to the ligaments supporting the lower urinary tract offers the best correlation with the observed LUTI. We propose a mechanism for this.
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- 2007
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45. MP29-08 INDICATIONS AND TIMING OF REVISION SURGERY IN PATIENTS HAVING HAD MULTIPLE ARTIFICIAL URINARY SPHINCTERS
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Daniela E. Andrich, Simon Bugeja, Anastasia Frost, and Anthony R. Mundy
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medicine.medical_specialty ,Neuropathic bladder ,business.industry ,Urology ,Urinary system ,Retrospective cohort study ,Mean age ,Single surgeon ,Surgery ,Artificial urinary sphincter ,Anesthesia ,Cohort ,medicine ,In patient ,business - Abstract
INTRODUCTION AND OBJECTIVES: Augmentation cystoplasty has been used for over 50 years as a surgical treatment for patients with dysfunctional bladder disorders. Some of these patients may require an artificial urinary sphincter (AUS) to maintain continence; and to perform clean intermittent self-catheterisation (CISC) to ensure bladder emptying. This study reviews outcomes of patients with neuropathic bladder disorders who have had both cystoplasty and AUS implantation. We compare the outcomes of those that regularly CISC with those that do not. METHODS: In this retrospective cohort study, 123 patients (77 male, 46 female) underwent augmentation cystoplasty, by a single surgeon, with implantation of an AUS. The cohort was divided into 2 groups. Group 1 (n1⁄467) performed CISC and group 2 (n1⁄456) did not. Mean age at time of initial surgery was 22 years (4.3-73 years). Mean follow up was 25 years (12-32 years). RESULTS: Of 123 patients, 85 (group 1 n1⁄442 vs. group 2 n1⁄443) had the AUS removed after a mean of 6.3 years (2 days 23.4 years). The mean time to explant was equal in groups 1 and 2 (6.4 years vs 6.2 years). In group 1, erosion occurred in 48.8%, infection in 2.4%, and malfunction 48.8%. The mean time to explant was 4.95 years (42 days 18 years) for erosion and 8.2 years (85 days 23.5 years) for malfunction. 1 patient had infection at 2 days. In group 2 the devices were removed due to erosion in 53.4%, and malfunction in 44.3%; after a mean of 5.1 years (60 days 21.4 years), and 9.6 years (0.7 23.5 years) respectively. There was 1 AUS removed for infection after 23 days. 51 patients went on to have a second AUS implanted with 28 (55%) being removed after a mean of 4.9 years, with 14 patients in each group. Erosion occurred in 39.2%, infection in 3.7%, and malfunction in 57.1%. The mean time to explant following erosion was similar in groups 1 and 2 (4.04 vs. 4.05 years). In group 1 there was one patient with infection at 91 days. There were no early infections in group 2. CONCLUSIONS: Patients with augmentation cystoplasty and an AUS developed erosion and infection at equal rates and mean time whether they performed CISC or not.
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- 2015
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46. PD22-01 THE NON-TRANSECTING TECHNIQUE FOR BULBAR URETHRAL STRICTURES
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Felix Campos, Anthony R. Mundy, Daniela E. Andrich, Enrique Fes, Anastasia Frost, and Simon Bugeja
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medicine.medical_specialty ,business.industry ,Urology ,Medicine ,business ,Surgery - Published
- 2015
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47. PI-01 RECTOURETHRAL FISTULAS SECONDARY TO PROSTATE CANCER TREATMENT: MANAGEMENT AND OUTCOMES
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Catherine R. Harris, Jack W. McAninch, Ramón Virasoro, Anthony R. Mundy, Leonard Zinman, Benjamin N. Breyer, Daniela E. Andrich, Gerald H. Jordan, and Alex J. Vanni
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Treatment management ,Oncology ,medicine.medical_specialty ,Prostate cancer ,business.industry ,Urology ,Internal medicine ,Medicine ,business ,medicine.disease - Published
- 2015
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48. PD14-11 SINGLE STAGE VERSUS CLASSICAL STAGED APPROACH FOR PENILE URETHRAL STRICTURES
- Author
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Stella Ivaz, Anastasia Frost, Anthony R. Mundy, Simon Bugeja, Enrique Fes, Felix Campos, and Daniela E. Andrich
- Subjects
medicine.medical_specialty ,business.industry ,Single stage ,Urology ,medicine ,business ,Surgery - Published
- 2015
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49. MP29-06 RECONSTRUCTIVE SURGERY FOR URO-RECTAL AND PERINEAL FISTULAE
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Daniela E. Andrich, Stella Ivaz, Simon Bugeja, Anthony R. Mundy, Anastasia Frost, and Enrique Fes
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Reconstructive surgery ,medicine.medical_specialty ,business.industry ,Urology ,Medicine ,business ,Surgery - Published
- 2015
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50. MP29-07 COMPLICATIONS ASSOCIATED WITH CLEAN INTERMITTENT SELF CATHETERISATION IN PATIENTS WITH ARTIFICIAL URINARY SPHINCTER FOR THE TREATMENT OF NEUROPATHIC BLADDER DYSFUNCTION
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Anthony R. Mundy, Michael Fadel, Andrew T. Cole, Daniela E. Andrich, Simon Bugeja, and Anastasia Frost
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medicine.medical_specialty ,Neuropathic bladder ,business.industry ,Urology ,Mean age ,Retrospective cohort study ,Single surgeon ,Surgery ,Artificial urinary sphincter ,Cohort ,Bladder Disorder ,Medicine ,In patient ,business - Abstract
INTRODUCTION AND OBJECTIVES: Augmentation cystoplasty has been used for over 50 years as a surgical treatment for patients with dysfunctional bladder disorders. Some of these patients may require an artificial urinary sphincter (AUS) to maintain continence; and to perform clean intermittent self-catheterisation (CISC) to ensure bladder emptying. This study reviews outcomes of patients with neuropathic bladder disorders who have had both cystoplasty and AUS implantation. We compare the outcomes of those that regularly CISC with those that do not. METHODS: In this retrospective cohort study, 123 patients (77 male, 46 female) underwent augmentation cystoplasty, by a single surgeon, with implantation of an AUS. The cohort was divided into 2 groups. Group 1 (n1⁄467) performed CISC and group 2 (n1⁄456) did not. Mean age at time of initial surgery was 22 years (4.3-73 years). Mean follow up was 25 years (12-32 years). RESULTS: Of 123 patients, 85 (group 1 n1⁄442 vs. group 2 n1⁄443) had the AUS removed after a mean of 6.3 years (2 days 23.4 years). The mean time to explant was equal in groups 1 and 2 (6.4 years vs 6.2 years). In group 1, erosion occurred in 48.8%, infection in 2.4%, and malfunction 48.8%. The mean time to explant was 4.95 years (42 days 18 years) for erosion and 8.2 years (85 days 23.5 years) for malfunction. 1 patient had infection at 2 days. In group 2 the devices were removed due to erosion in 53.4%, and malfunction in 44.3%; after a mean of 5.1 years (60 days 21.4 years), and 9.6 years (0.7 23.5 years) respectively. There was 1 AUS removed for infection after 23 days. 51 patients went on to have a second AUS implanted with 28 (55%) being removed after a mean of 4.9 years, with 14 patients in each group. Erosion occurred in 39.2%, infection in 3.7%, and malfunction in 57.1%. The mean time to explant following erosion was similar in groups 1 and 2 (4.04 vs. 4.05 years). In group 1 there was one patient with infection at 91 days. There were no early infections in group 2. CONCLUSIONS: Patients with augmentation cystoplasty and an AUS developed erosion and infection at equal rates and mean time whether they performed CISC or not.
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- 2015
- Full Text
- View/download PDF
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