12 results on '"Chen, Huan-Sheng"'
Search Results
2. Tinnitus as a Potential Risk Factor for Uveitis: A 14-Year Nationwide Population-Based Cohort Study in Taiwan.
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Chen YJ, Hsu AY, Lin CJ, Hsia NY, Meng PP, Liao PL, Hsu MY, Tien PT, Lai CT, Chen HS, Chiang CC, and Tsai YY
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- Humans, Taiwan epidemiology, Female, Male, Retrospective Studies, Incidence, Risk Factors, Middle Aged, Adult, Aged, Young Adult, Follow-Up Studies, Databases, Factual, Adolescent, Tinnitus epidemiology, Tinnitus etiology, Uveitis epidemiology, Uveitis diagnosis
- Abstract
Background: Tinnitus and uveitis have shared commonality in pathophysiology in terms of autoimmunity. However, no studies that have linked any association between the conditions of tinnitus and uveitis., Methods: This is a retrospective study conducted from the Taiwan National Health Insurance database in order to investigate whether tinnitus patients are at increased risk of uveitis. Patients newly diagnosed with tinnitus between 2001 and 2014 were recruited and followed up until 2018. The endpoint of interest was a diagnosis of uveitis., Results: A total of 31,034 tinnitus patients and 124,136 matched comparisons were analyzed. Tinnitus patients were found to have a significantly higher cumulative incidence for uveitis than those without the diagnosis of tinnitus with incidence rate of 1.68 (95% CI 1.55-1.82) per 10 000 person-months for tinnitus group and 1.48 (95% CI 1.42-1.54) per 10 000 person-months for non-tinnitus group., Conclusion: Tinnitus patients were found to have increased risk of developing uveitis.
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- 2024
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3. Re: Chang et al.: Incident noninfectious uveitis risk after immune checkpoint treatment (Ophthalmology. 2024;131:867-869).
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Hsu AY, Lin CJ, Chen HS, and Tsai YY
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- Humans, Incidence, Risk Factors, Uveitis chemically induced, Uveitis drug therapy, Uveitis diagnosis, Immune Checkpoint Inhibitors adverse effects
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- 2024
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4. Prevalence of uveitis in syphilis patients in Taiwan.
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Chen CY, Kuo HT, Hsu AY, Lin CJ, Hsia NY, Tien PT, Lai CT, Chen HS, and Tsai YY
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- Male, Humans, Retrospective Studies, Risk Factors, Taiwan epidemiology, Prevalence, Incidence, Syphilis epidemiology, Uveitis epidemiology, Uveitis diagnosis
- Abstract
Few population-based studies have looked at the risk of uveitis among syphilis patients. Our study addresses the knowledge gap by reporting on uveitis risk in syphilis patients through a retrospective cohort study. The Taiwan National Health Insurance database was used for this study, covering the period from January 1st, 2009, to December 31st, 2020. We created a 1:4 propensity score matched cohort between the syphilis patients and controls, which accounted for gender, age, and comorbidities. The primary endpoint was the incidence of newly recorded uveitis. The assessment of uveitis risk in syphilis patients included the use of the Kaplan-Meier method and multivariate Cox proportional hazard model. A total of 31,597 syphilis patients and 126,379 matched comparisons were recruited. The uveitis incidence rate from our syphilis patients was 1.25 per 1000 person-years. The uveitis incidence rate from our non-syphilis group was 0.8 per 1000 person-years. After matching, the syphilis group was found to have a higher risk of developing uveitis (adjusted hazard ratio (aHR) [95% CI]: 1.57 [1.36-1.81], P < .001). Among males and individuals aged 20-34 years, subgroup analysis showed an increased risk of uveitis in the presence of syphilis infection. The Kaplan-Meier survival curve showed a significant difference in uveitis incidence between syphilis and non-syphilis groups (log-rank test P < .001). In summary, our study revealed that Taiwanese syphilis patients were at a higher risk of developing uveitis. These results highlight the need for regular ocular monitoring and screening in individuals with syphilis.
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- 2024
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5. Cataract Development Among Pediatric Patients With Uveitis.
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Hsu AY, Kuo HT, Lin CJ, Hsia NY, Kuo SC, Wei CC, Lai CT, Chen HS, Wang YH, Wei JC, and Tsai YY
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- Humans, Male, Female, Child, Adolescent, Child, Preschool, Risk Factors, Cohort Studies, Infant, Proportional Hazards Models, Uveitis epidemiology, Uveitis etiology, Cataract epidemiology, Cataract complications, Cataract etiology
- Abstract
Importance: The long-term estimated risk of development of cataracts among pediatric patients with uveitis is not clear., Objective: To describe factors associated with the development of cataracts among pediatric patients with uveitis., Design, Setting, and Participants: This cohort study used the international TriNetX database to enroll pediatric patients with and without uveitis from January 1, 2002, to December 31, 2022. The nonuveitis cohort consisted of randomly selected control patients matched by age, sex, race and ethnicity, and specific comorbidities., Exposure: Diagnosis of uveitis, identified using diagnostic codes., Main Outcomes and Measures: The primary outcome was the risk of developing cataracts among the uveitis group compared with the nonuveitis comparison group, with hazard ratios (HRs) and 95% CIs reported., Results: A total of 22 687 pediatric patients with uveitis (mean [SD] age, 10.3 [5.6] years; 54.2% male) and 22 687 comparators without uveitis (mean [SD] age, 10.3 [5.6] years; 54.5% male) were enrolled in the study. The risk of cataracts was increased among pediatric patients with uveitis up to a follow-up duration of 20 years (HR, 17.17; 95%CI, 12.90-22.80) from the index date. Subgroup analyses revealed an elevated cataract risk across age groups: 0 to 6 years (HR, 19.09; 95% CI, 10.10-36.00), 7 to 12 years (HR, 27.16; 95% CI, 15.59-47.20), and 13 to 18 years (HR, 13.39; 95% CI, 8.84-20.30); both female sex (HR, 13.76; 95% CI, 9.60-19.71) and male sex (HR, 11.97; 95% CI, 8.47-16.91); and Asian (HR, 13.80; 95% CI, 3.28-58.07), Black or African American (HR, 10.41; 95% CI, 5.60-19.36), and White (HR, 15.82; 95% CI, 11.05-22.60) race. Furthermore, increased cataract risks were also observed among those with and without a history of immunosuppressive agents (with: HR, 26.52 [95% CI, 16.75-41.90]; without: HR, 17.69 [95% CI: 11.39-27.40]), a history of steroid eye drop use (with: HR, 29.51 [95% CI, 14.56-59.70]; without: HR, 16.49 [95% CI, 11.92-22.70]), and a history of intraocular procedures (with: HR, 11.07 [95%CI, 4.42-27.71]; without: HR, 14.49 [95% CI, 10.11-20.70])., Conclusions and Relevance: In this cohort study of pediatric patients with uveitis, an elevated risk of cataracts following a uveitis diagnosis was found compared with pediatric patients without uveitis. The findings suggest that pediatric patients with uveitis should be monitored for cataract development.
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- 2024
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6. Reply to comment on "The risk assessment of uveitis after COVID-19 diagnosis by Wu et al. 2024".
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Hsu AY, Lin CJ, Hsia NY, Wang YH, Li JX, Chen HS, Wei JC, and Tsai YY
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- Humans, Risk Assessment, SARS-CoV-2 genetics, COVID-19 diagnosis, COVID-19 complications, Uveitis diagnosis, Uveitis etiology, Uveitis virology
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- 2024
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7. Assessing Uveitis Risk following Pediatric Down Syndrome Diagnosis: A TriNetX Database Study.
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Hsu AY, Wang YH, Lin CJ, Li YL, Hsia NY, Lai CT, Kuo HT, Chen HS, Tsai YY, and Wei JC
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- Humans, Male, Female, Child, Retrospective Studies, Child, Preschool, Adolescent, Infant, Databases, Factual, Incidence, Cohort Studies, Risk Factors, Risk Assessment methods, Risk Assessment statistics & numerical data, Down Syndrome complications, Uveitis epidemiology, Uveitis diagnosis, Uveitis etiology
- Abstract
Background and Objectives: The risks of uveitis development among pediatric patients with Down syndrome (DS) remain unclear. Therefore, we aimed to determine the risk of uveitis following a diagnosis of DS. Materials and Methods: This multi-institutional retrospective cohort study utilized the TriNetX database to identify individuals aged 18 years and younger with and without a diagnosis of DS between 1 January 2000 and 31 December 2023. The non-DS cohort consisted of randomly selected control patients matched by selected variables. This included gender, age, ethnicity, and certain comorbidities. The main outcome is the incidence of new-onset uveitis. Statistical analysis of the uveitis risk was reported using hazard ratios (HRs) and 95% confidence intervals (CIs). Separate analyses of the uveitis risk among DS patients based on age groups and gender were also performed. Results: A total of 53,993 individuals with DS (46.83% female, 58.26% white, mean age at index 5.21 ± 5.76 years) and 53,993 non-DS individuals (45.56% female, 58.28% white, mean age at index 5.21 ± 5.76 years) were recruited from the TriNetX database. Our analysis also showed no overall increased risk of uveitis among DS patients (HR: 1.33 [CI: 0.89-1.99]) compared to the non-DS cohort across the 23-year study period. Subgroup analyses based on different age groups showed that those aged 0-1 year (HR: 1.36 [CI: 0.68-2.72]), 0-5 years (HR: 1.34 [CI: 0.75-2.39]), and 6-18 years (HR: 1.15 [CI: 0.67-1.96]) were found to have no association with uveitis risk compared to their respective non-DS comparators. There was also no increased risk of uveitis among females (HR: 1.49 [CI: 0.87-2.56]) or males (HR: 0.82 [CI: 0.48-1.41]) with DS compared to their respective non-DS comparators. Conclusions: Our study found no overall increased risk of uveitis following a diagnosis of DS compared to a matched control population.
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- 2024
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8. The risk assessment of uveitis after COVID-19 diagnosis: A multicenter population-based study.
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Hsia NY, Hsu AY, Wang YH, Li JX, Chen HS, Wei JC, Lin CJ, and Tsai YY
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- Humans, Female, Adult, Male, Retrospective Studies, SARS-CoV-2, Risk Assessment, COVID-19 complications, COVID-19 diagnosis, Uveitis diagnosis, Uveitis epidemiology, Uveitis etiology
- Abstract
Reports on uveitis after COVID-19 have been limited. Our objective was to examine the risk of uveitis among COVID-19 patients. This was a retrospective cohort study based on the TriNetX platform. The exposure group was patients with positive laboratory test result for SARS-CoV-2 and the comparison group was those tested negative for COVID-19 throughout the study period. The endpoint is the new diagnoses of uveitis. This study composed of 2 105 424 patients diagnosed with COVID-19 (55.4% female; 62.5% white; mean age at index 40.7 years) and 2 105 424 patients (55.4% female; 62.4% white; mean age at index 40.7 years) who never had COVID-19. There was significantly increased risk of new diagnosis of uveitis since the first month after diagnosis of COVID-19 compared with matched controls (HR: 1.18, 95% CI: 1.03-1.34) up to 24 months (HR: 1.16, 95% CI: 1.09-1.22). Our findings strengthen those previously raised by case series with a larger and multicenter study. We found that uveitis was significantly associated with COVID-19 infection. Our findings reiterate the need for careful investigation as well as increased awareness from ophthalmologists in considering the possibility of COVID-19 in vulnerable patients with new presentation of uveitis., (© 2023 Wiley Periodicals LLC.)
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- 2023
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9. The incidence of uveitis after systemic lymphoma in Taiwan: An 18-year nationwide population-based cohort study.
- Author
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Huang YT, Lin CJ, Liao PL, Hsu MY, Chang CH, Tien PT, Lai CT, Hsia NY, Bair H, Chen HS, Chiang CC, and Tsai YY
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- Adult, Aged, Cohort Studies, Female, Humans, Incidence, Lymphoma epidemiology, Male, Middle Aged, Proportional Hazards Models, Retrospective Studies, Risk Factors, Taiwan epidemiology, Uveitis etiology, Lymphoma complications, Uveitis epidemiology
- Abstract
Abstract: Although uveitis can be an intraocular presentation of systemic lymphoma, it may be associated with direct lymphomatous infiltration and immune-mediated alterations. There have been no published studies describing the incidence of uveitis after systemic lymphoma. We conducted a nationwide cohort study to investigate the incidence of uveitis after systemic lymphoma diagnosis in Taiwan. Data were collected from the Taiwan National Health Insurance system and included patients newly diagnosed with systemic lymphoma between 2000 and 2017. We observed the risk of uveitis among study population since the index date until December 2017. The 1:8 of systemic lymphoma patient and paired comparison was identified by time distribution matching and individual paired with sex and age. Subsequent propensity score matching (PSM) was used to select the 1:1 of systemic lymphoma patient and paired comparison by greedy algorism with caliper of 0.05. The multiple Cox proportional hazard regression model was used to compare the developmental risk of uveitis (time-to-uveitis) between the systemic lymphoma and non-systemic lymphoma, while controlling for selected covariates. After time distribution matching, we selected 6846 patients with systemic lymphoma, and 54,768 comparisons. Among patients with systemic lymphoma groups, there were more men than women (52.94% vs 47.06%) and the mean age was 53.32 ± 21.22 years old. Systemic lymphoma incidence rates (per 10,000 person-months) of uveitis were 1.94 (95% confidence interval [CI], 1.60-2.35) in the systemic lymphoma cohort and 1.52 (95% CI, 1.42-1.63) in the non-systemic lymphoma cohort. Compared with the non-systemic lymphoma cohort, adjusted hazard ratio (aHR) of developing uveitis were 1.24 (95% CI, 1.00-1.52) in people with systemic lymphoma. But not significant in after PSM, aHR of developing uveitis were 1.17 (95% CI, 0.90-1.53). This 18-year nationwide population-based cohort study in Taiwan, showed that the risk of uveitis in patients' systemic lymphoma was not significantly higher than non-systemic lymphoma after PSM. In elderly and rheumatic patients with intraocular inflammation, it is important to first exclude uveitis masquerade syndrome, which could be a harbinger of intraocular involvement from systemic lymphoma. Further large-scale prospective clinical studies to investigate whether systemic lymphoma influences the incidence of uveitis are warranted., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2022
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10. Relationship between Uveitis and Thyroid Disease: A 13-Year Nationwide Population-based Cohort Study in Taiwan.
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Lin CJ, Tien PT, Chang CH MD, PhD, Hsia NY, Yang YC, Lai CT, Bair H, Chen HS, and Tsai YY
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- Adult, Aged, Cohort Studies, Databases, Factual, Female, Humans, Incidence, Male, Middle Aged, National Health Programs statistics & numerical data, Retrospective Studies, Risk Factors, Taiwan epidemiology, Thyroid Diseases physiopathology, Uveitis physiopathology, Young Adult, Thyroid Diseases epidemiology, Uveitis epidemiology
- Abstract
Purpose : To investigate whether patients with thyroid disease are at increased risk of uveitis. Methods : Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with thyroid disease from 2000 to 2012. The endpoint of interest was a diagnosis of uveitis. Results : In analyzing 21,396 patients with thyroid disease, yielding 85,584 matched comparisons, patients with thyroid disease to have a significantly higher cumulative incidence of uveitis when compared to the control cohort with the Kaplan-Meier analysis. This result was further confirmed by Cox regression analysis. The increased risk was persistent in both genders. The association between thyroid disease and uveitis was stronger in patients without diabetes or hypertension. Conclusion : Patients with thyroid disease were found to have a higher risk for uveitis. For certain age groups or patients without diabetes or hypertension, the role of thyroid disease might be more crucial for uveitis development.
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- 2021
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11. RELATIONSHIP BETWEEN UVEITIS, DIFFERENT TYPES OF VIRAL HEPATITIS, AND LIVER CIRRHOSIS: A 12-Year Nationwide Population-Based Cohort Study.
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Tien PT, Lin CJ, Tsai YY, Chen HS, Hwang DK, Muo CH, Lin JM, and Chen WL
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- Adult, Aged, Cohort Studies, Coinfection, Female, Humans, Incidence, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Taiwan epidemiology, Young Adult, Hepatitis B epidemiology, Hepatitis C epidemiology, Liver Cirrhosis, Alcoholic epidemiology, Uveitis epidemiology
- Abstract
Purpose: This study investigates whether patients with viral hepatitis and cirrhosis are at risk of uveitis in the years following hepatitis., Methods: We used data from Taiwan National Health Insurance system. The cases were patients newly diagnosed with viral hepatitis from 2000 to 2011. The end point of interest was a diagnosis of uveitis. A chi-square test was used for the difference of demographic characteristics between viral hepatitis and comparison. The risk of uveitis in hepatitis was stratified using Cox proportional hazard regression., Results: We selected 17,389 patients with viral hepatitis and 34,778 matched comparison. The risk of uveitis in hepatitis cohort was 1.30-fold (95% confidence interval = 1.01-1.69). Patients with hepatitis B virus and hepatitis C virus coinfection had the highest risk (hazard ratio = 2.88; 95% confidence interval = 1.07-7.78), and followed by only hepatitis C virus infection (hazard ratio = 1.75; 95% confidence interval = 1.10-2.79). Patients with cirrhosis had a higher risk in the multivariable model but did not attach statistic difference., Conclusion: Patients with hepatitis B virus and hepatitis C virus coinfection had the highest risk of uveitis. In patients with hepatitis C virus and/or hepatitis B virus infection, the symptoms of uveitis should be alerted. Although these epidemiologic studies yielded informative results, the underlying mechanisms and the host's genetic factors remain to be investigated., Competing Interests: The authors were involved in design and conduct of study; data collection; analysis, management, and interpretation of data; and preparation, review, and approval of manuscript. None of the authors have any financial/conflicting interests to disclose.
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- 2016
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12. Chronic Kidney Disease as A Potential Risk Factor for Uveitis: A 13-Year Nationwide Population-Based Cohort Study in Taiwan.
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Lin, Chun-Ju, Tien, Peng-Tai, Lai, Chun-Ting, Hsia, Ning-Yi, Chang, Cheng-Hsien, Bair, Henry, Chen, Huan-Sheng, Yang, Yu-Cih, Lin, Jan-Ming, Chen, Wen-Lu, and Tsai, Yi-Yu
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DISEASE risk factors ,IRIDOCYCLITIS ,UVEITIS - Abstract
To investigate whether patients with chronic kidney disease (CKD) are at increased risk of uveitis. Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with CKD between 2000 and 2012. The endpoint of interest was a diagnosis of uveitis. 30,256 CKD patients and 121,024 matched comparisons were analyzed. CKD patients were found to have a significantly higher cumulative uveitis incidence. Through multivariate Cox regression analysis, the CKD group was found to have higher risk of developing uveitis (adjusted hazard ratio 1.51). After stratified by gender, age, and comorbidities (hypertension, diabetes, and hyperlipidemia), the increased risk of uveitis in CKD patients remained significant. Patients with CKD were found to have higher risk of developing uveitis. For patients over 18 years old and with hypertension, diabetes, or hyperlipidemia, the presence of CKD was demonstrated as an additional crucial factor for uveitis development. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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