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4 results on '"Morrone LF"'

1. Impact of BMI on cardiovascular events, renal function, and coronary artery calcification.

Author

Russo D, Morrone LF, Errichiello C, De Gregorio MG, Imbriaco M, Battaglia Y, Russo L, Andreucci M, and Di Iorio BR

Subjects
Adult, Aged, C-Reactive Protein metabolism, Calcium blood, Cholesterol, LDL blood, Cohort Studies, Coronary Artery Disease blood, Coronary Artery Disease complications, Coronary Vessels metabolism, Coronary Vessels physiopathology, Diabetes Mellitus physiopathology, Disease Progression, Female, Glomerular Filtration Rate, Hemoglobins metabolism, Humans, Hypertension physiopathology, Male, Middle Aged, Parathyroid Hormone blood, Phosphorus blood, Proteinuria blood, Proteinuria complications, Renal Dialysis, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic complications, Serum Albumin metabolism, Time Factors, Vascular Calcification blood, Vascular Calcification complications, Body Mass Index, Coronary Artery Disease physiopathology, Proteinuria physiopathology, Renal Insufficiency, Chronic physiopathology, Vascular Calcification physiopathology
Abstract

Background/aims: High BMI increases the risk of cardiovascular events (CVEs) in the general population. Conflicting results have been reported on the role of BMI on CVEs and on decline of renal function in patients with chronic kidney disease not on dialysis (CKD). This study evaluates the impact of BMI on CVEs, dialysis initiation, and coronary artery calcification (CAC) in CKD patients., Methods: CKD patients were divided in normal-BMI and high-BMI patients. CVEs, initiation of dialysis, and extent and progression of CAC were assessed. Univariate and multivariable analysis were performed (adjustment variables: age, diabetes, hypertension, gender, CKD stage, serum concentration of hemoglobin, parathyroid hormone, calcium, phosphorus, albumin, C-reactive protein, LDL-cholesterol, total calcium score, 24-hour proteinuria). Patients were followed to the first event (CVE, dialysis) or for 2 years., Results: 471 patients were evaluated. A CVE occurred in 13.5 and 21.3% (p < 0.05) of normal-BMI and high-BMI patients, respectively. High BMI did not increase the risk for CVEs in univariate (HR: 1.86; 95% CI: 0.97-3.54; p = 0.06) or multivariable analysis (HR: 1.36; 95% CI: 0.57-3.14; p = 0.50). High BMI did not increase the risk for initiation of dialysis in univariate (HR: 0.96; 95% CI: 0.58-1.60; p = 0.9) or multivariable analysis (HR: 1.77; 95% CI: 0.82-3.81; p = 0.14). Adding the interaction term (between BMI and glomerular filtration rate) to other variables, the risk of dialysis initiation significantly increased (HR: 3.06; 95% CI: 1.31-7.18; p = 0.01) in high-BMI patients. High BMI was not a predictor of CAC extent or progression., Conclusions: High BMI was not a predictor of CVEs. High BMI increased the risk for dialysis initiation, but high BMI was not associated to CAC extent and progression. The presence of confounders may underestimate the impact of high BMI on dialysis initiation., (© 2014 S. Karger AG, Basel.)

Published
2014
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2. Coronary artery calcification and outcomes in diabetic patients with and without chronic kidney disease.

Author

Russo D, Morrone LF, Imbriaco M, Pota A, Russo L, Scognamiglio B, and Sorrentino R

Subjects
Adult, Aged, Coronary Artery Disease epidemiology, Coronary Vessels pathology, Disease Progression, Female, Humans, Male, Middle Aged, Prevalence, Prognosis, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Vascular Calcification epidemiology, Coronary Artery Disease complications, Coronary Artery Disease diagnosis, Diabetes Mellitus, Renal Insufficiency, Chronic complications, Vascular Calcification diagnosis
Abstract

Background/aims: Presence and progression of coronary artery calcification (CAC) indicate severe atherosclerosis and predict cardiovascular events (CVE) in dialysis (ESRD patients) and nondialysis patients (CKD patients). This study aimed at evaluating the prevalence and progression of CAC and CVE in CKD patients with diabetes in whom atherosclerosis of coronary arteries is the leading cause of CVE., Methods: This was a retrospective study conducted in both out- and in-patients with chronic kidney disease, stage 2-5. CAC were assessed by the total calcium (TC) score. CT scans were performed at the entry and at the end of the study., Results: Patients (n = 341) were divided into nondiabetic (n = 281) and diabetic patients (n = 60). CAC prevalence and TC score were higher in diabetics and associated with age, diabetes mellitus and pulse pressure. Diabetics with CKD presented a higher percentage of CAC progression and CVE., Conclusion: Prevalence, extent, progression of CAC and CVE are higher in diabetics with concomitant CKD. These findings may promote a more aggressive protocol of screening and care in type 2 diabetics with concomitant CKD., (Copyright © 2013 S. Karger AG, Basel.)

Published
2013
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3. Impact of BMI on cardiovascular events, renal function, and coronary artery calcification

Author

Luigi Russo, Carmela Errichiello, Domenico Russo, Biagio Di Iorio, Michele Andreucci, Massimo Imbriaco, Maria Grazia De Gregorio, Yuri Battaglia, Luigi Morrone, Russo, Domenico, Morrone, Lf, Errichiello, C, De Gregorio, Mg, Imbriaco, Massimo, Battaglia, Y, Russo, L, Andreucci, M, and Di Iorio, Br

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Population, Renal function, Coronary Artery Disease, End stage renal disease, Body Mass Index, Cohort Studies, chemistry.chemical_compound, Hemoglobins, Renal Dialysis, Internal medicine, medicine, Diabetes Mellitus, Humans, BMI · Cardiovascular events · End-stage renal disease · Coronary calcification progression · Confounders, Renal Insufficiency, Chronic, education, Vascular Calcification, Serum Albumin, Aged, education.field_of_study, business.industry, Cholesterol, Confounding, nutritional and metabolic diseases, Phosphorus, Hematology, General Medicine, Cholesterol, LDL, Middle Aged, Coronary Vessels, Proteinuria, C-Reactive Protein, chemistry, Nephrology, Parathyroid Hormone, Coronary artery calcification, Hypertension, Cardiology, Disease Progression, Calcium, Female, business, Body mass index, Cohort study, Glomerular Filtration Rate
Abstract

Background/Aims: High BMI increases the risk of cardiovascular events (CVEs) in the general population. Conflicting results have been reported on the role of BMI on CVEs and on decline of renal function in patients with chronic kidney disease not on dialysis (CKD). This study evaluates the impact of BMI on CVEs, dialysis initiation, and coronary artery calcification (CAC) in CKD patients. Methods: CKD patients were divided in normal-BMI and high-BMI patients. CVEs, initiation of dialysis, and extent and progression of CAC were assessed. Univariate and multivariable analysis were performed (adjustment variables: age, diabetes, hypertension, gender, CKD stage, serum concentration of hemoglobin, parathyroid hormone, calcium, phosphorus, albumin, C-reactive protein, LDL-cholesterol, total calcium score, 24-hour proteinuria). Patients were followed to the first event (CVE, dialysis) or for 2 years. Results: 471 patients were evaluated. A CVE occurred in 13.5 and 21.3% (p < 0.05) of normal-BMI and high-BMI patients, respectively. High BMI did not increase the risk for CVEs in univariate (HR: 1.86; 95% CI: 0.97-3.54; p = 0.06) or multivariable analysis (HR: 1.36; 95% CI: 0.57-3.14; p = 0.50). High BMI did not increase the risk for initiation of dialysis in univariate (HR: 0.96; 95% CI: 0.58-1.60; p = 0.9) or multivariable analysis (HR: 1.77; 95% CI: 0.82-3.81; p = 0.14). Adding the interaction term (between BMI and glomerular filtration rate) to other variables, the risk of dialysis initiation significantly increased (HR: 3.06; 95% CI: 1.31-7.18; p = 0.01) in high-BMI patients. High BMI was not a predictor of CAC extent or progression. Conclusions: High BMI was not a predictor of CVEs. High BMI increased the risk for dialysis initiation, but high BMI was not associated to CAC extent and progression. The presence of confounders may underestimate the impact of high BMI on dialysis initiation.

Published
2014

4. Coronary artery calcification and outcomes in diabetic patients with and without chronic kidney disease

Author

Luigi Russo, Massimo Imbriaco, R. Sorrentino, Bernadette Scognamiglio, Domenico Russo, Andrea Pota, Luigi Morrone, Russo, D, Morrone, Lf, Imbriaco, Massimo, Pota, A, Russo, L, Scognamiglio, B, and Sorrentino, R.

Subjects
Adult, Male, Coronary artery · Calcification · Chronic kidney disease · Diabetes · Progression · Cardiovascular events, medicine.medical_specialty, medicine.medical_treatment, Coronary Artery Disease, Coronary artery disease, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Prevalence, Humans, Renal Insufficiency, Chronic, Vascular Calcification, Dialysis, Aged, Retrospective Studies, business.industry, nutritional and metabolic diseases, Retrospective cohort study, Hematology, General Medicine, Middle Aged, medicine.disease, Prognosis, Coronary Vessels, Pulse pressure, Coronary arteries, medicine.anatomical_structure, Nephrology, Concomitant, Cardiology, Disease Progression, Female, business, Tomography, X-Ray Computed, Kidney disease
Abstract

Background/Aims: Presence and progression of coronary artery calcification (CAC) indicate severe atherosclerosis and predict cardiovascular events (CVE) in dialysis (ESRD patients) and nondialysis patients (CKD patients). This study aimed at evaluating the prevalence and progression of CAC and CVE in CKD patients with diabetes in whom atherosclerosis of coronary arteries is the leading cause of CVE. Methods: This was a retrospective study conducted in both out- and in-patients with chronic kidney disease, stage 2-5. CAC were assessed by the total calcium (TC) score. CT scans were performed at the entry and at the end of the study. Results: Patients (n = 341) were divided into nondiabetic (n = 281) and diabetic patients (n = 60). CAC prevalence and TC score were higher in diabetics and associated with age, diabetes mellitus and pulse pressure. Diabetics with CKD presented a higher percentage of CAC progression and CVE. Conclusion: Prevalence, extent, progression of CAC and CVE are higher in diabetics with concomitant CKD. These findings may promote a more aggressive protocol of screening and care in type 2 diabetics with concomitant CKD.

Published
2013

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