7 results on '"Chi, Di"'
Search Results
2. Successful intravenous streptokinase treatment of a child with Kawasaki disease complicated by acute myocardial infarction
- Author
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Chi‐Di Liang, Song‐Chei Huang, Wen‐Jen Su, Chiang‐Hsuan Lee, and Hui‐Yung Chen
- Subjects
Male ,medicine.medical_specialty ,Streptokinase ,Myocardial Infarction ,Mucocutaneous Lymph Node Syndrome ,Electrocardiography ,Internal medicine ,medicine ,Humans ,Thrombolytic Therapy ,cardiovascular diseases ,Myocardial infarction ,Child ,Infusions, Intravenous ,Radionuclide Imaging ,skin and connective tissue diseases ,medicine.diagnostic_test ,business.industry ,Vascular disease ,Coronary Aneurysm ,Heart ,medicine.disease ,Echocardiography ,Angiography ,cardiovascular system ,Cardiology ,Kawasaki disease ,Myocardial infarction diagnosis ,Cardiology and Cardiovascular Medicine ,business ,Vasculitis ,medicine.drug - Abstract
A 9-year-old boy developed ischemic cardiac symptoms 1 year after he presented with Kawasaki disease. The myocardial infarction was confirmed by the typical changes of electrocardiograms, echocardiograms, cardiac enzymes, thallium myocardial scintigrams, and angiograms. With successful intravenous streptokinase therapy, he remained well during the following 4 months.
- Published
- 1995
3. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
- Author
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Meng-Luen Lee, Luan-Yin Chang, Kao-Pin Hwang, Jer-Yuarn Wu, Li-Min Huang, Hsin Chi, Fu-Yuan Huang, Chi-Di Liang, Ying Ju Chen, Chien Hsiun Chen, Ho-Chang Kuo, Ming-Ren Chen, Yi-Min Liu, Li-Ching Chang, Yuan-Tsong Chen, Betau Hwang, Nan-Chang Chiu, Yhu-Chering Huang, Jeng Sheng Chang, Fuu Jen Tsai, Pi-Chang Lee, and Yi-Ching Lee
- Subjects
Autoimmune disease ,Genetic Markers ,Systemic disease ,Case-control study ,Taiwan ,Genome-wide association study ,Biology ,Mucocutaneous Lymph Node Syndrome ,medicine.disease ,Polymorphism, Single Nucleotide ,Pathogenesis ,Genetic Loci ,hemic and lymphatic diseases ,Immunopathology ,Case-Control Studies ,Immunology ,Genetics ,medicine ,Humans ,Kawasaki disease ,Genetic Predisposition to Disease ,Vasculitis ,Genome-Wide Association Study - Abstract
Jer-Yuarn Wu, Fuu-Jen Tsai, Yuan-Tsong Chen and colleagues report a genome-wide association study of Kawasaki disease. They show that common variants near BLK and CD40 influence susceptibility to this acute childhood vasculitis. To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10−8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.
- Published
- 2011
4. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
- Author
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Lee, Yi-Ching, Kuo, Ho-Chang, Chang, Jeng-Sheng, Chang, Luan-Yin, Huang, Li-Min, Chen, Ming-Ren, Liang, Chi-Di, Chi, Hsin, Huang, Fu-Yuan, Lee, Meng-Luen, Huang, Yhu-Chering, Hwang, Betau, Chiu, Nan-Chang, Hwang, Kao-Pin, Lee, Pi-Chang, Chang, Li-Ching, Liu, Yi-Min, Chen, Ying-Ju, Chen, Chien-Hsiun, and Alliance, Taiwan Pediatric ID
- Subjects
MUCOCUTANEOUS lymph node syndrome diagnosis ,VASCULITIS ,CHINESE people ,PROTEIN-tyrosine kinases ,PATHOGENIC microorganisms ,DISEASE risk factors ,DISEASES - Abstract
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10
?8 ). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. [ABSTRACT FROM AUTHOR]- Published
- 2012
- Full Text
- View/download PDF
5. Lack of Association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki Disease in the Taiwanese Children.
- Author
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Kuo, Ho-Chang, Lin, Ying-Jui, Juo, Suh-Hang, Hsu, Yu-Wen, Chen, Wei-Chiao, Yang, Kuender, Liang, Chi-Di, Yang, Shengyu, Chao, Mei-Chyn, Yu, Hong-Ren, Wang, Shouyan, Lin, Li-Yan, and Chang, Wei-Chiao
- Subjects
GENETIC polymorphisms ,MUCOCUTANEOUS lymph node syndrome ,TAIWANESE people ,VASCULITIS ,CORONARY arteries ,IMMUNOGLOBULINS ,DISEASES - Abstract
Objective: Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C ( ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods: A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results: No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions: This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
6. CTLA-4, Position 49 A/G Polymorphism Associated with Coronary Artery Lesions in Kawasaki Disease.
- Author
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Kuo, Ho-Chang, Liang, Chi-Di, Yu, Hong-Ren, Wang, Chih-Lu, Lin, I-Chun, Liu, Chieh-An, Chang, Jen-Chieh, Lee, Chiu-Ping, Chang, Wei-Chiao, and Yang, Kuender
- Subjects
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MUCOCUTANEOUS lymph node syndrome , *CORONARY disease , *GENETIC polymorphisms , *VASCULITIS , *ETIOLOGY of diseases , *AUTOIMMUNITY , *STATISTICAL correlation - Abstract
Objective: Kawasaki disease (KD) is a systemic vasculitis of unknown etiology and primarily affects children less than 5 years of age. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has been suggested as a candidate gene for conferring susceptibility to autoimmunity. This study examined the correlation of CTLA-4 gene polymorphisms in KD with and without coronary artery lesions (CAL). Materials and methods: A total of 233 KD patients and 644 controls were subjected to determination of CTLA-4 polymorphisms at (−318) C/T and (+49) A/G positions by restriction fragment length polymorphism. Susceptibility, CAL, and intravenous immunoglobulin treatment response of KD were then analyzed with genetic variants. Results: Polymorphisms of CTLA-4 (+49 A/G) and (−318 C/T) were not significantly different between normal children and patients with KD. The CTLA-4 (+49) A allele (AA+AG genotype), however, was significantly associated with CAL formation, especially in female patients. Conclusions: This study provides the first evidence supporting the association of CTLA-4 (+49) A/G polymorphism with the CAL formation of KD particularly in female patients. [ABSTRACT FROM AUTHOR]
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- 2011
- Full Text
- View/download PDF
7. CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children.
- Author
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Kuo, Ho-Chang, Yu, Hong-Ren, Juo, Suh-Hang Hank, Yang, Kuender D, Wang, Yu-Shiuan, Liang, Chi-Di, Chen, Wei-Chiao, Chang, Wei-Pin, Huang, Chien-Fu, Lee, Chiu-Ping, Lin, Li-Yan, Liu, Yu-Chen, Guo, Yuh-Cherng, Chiu, Chien-Chih, and Chang, Wei-Chiao
- Subjects
GENETIC polymorphisms ,MUCOCUTANEOUS lymph node syndrome ,PEDIATRICS ,HUMAN genetics ,NUCLEOTIDES ,VASCULITIS ,ETIOLOGY of diseases - Abstract
Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. A study from Japan reported that G to A substitution of a single-nucleotide polymorphism (SNP) located in the 5′-untranslated region of caspase 3 (CASP3) (rs72689236), which was associated with nuclear factor of activated T cell-mediated T-cell activation, is responsible for susceptibility to KD. This study was conducted to investigate whether the polymorphism of CASP3 is responsible for susceptibility and coronary artery lesion (CAL) formation in KD in the Taiwanese population. A total of 1092 subjects (341 KD patients and 751 controls) were investigated to identify an SNP of rs72689236 using Invader assays (Third Wave Technologies). Our data provided a borderline significant association between the genotypes and allele frequency of rs72689236 in control subjects and KD patients (P=0.0535 under the dominant model; P=0.0575 under the allelic model). The A allele of rs72689236 in KD patients and in patients with CAL and intravenous immunoglobulin resistance was seen in a higher frequency. Importantly, a significant association was obtained between rs72689236 and KD patients with aneurysm formation (P=0.009, under the recessive model). The A allele of rs72689236 is very likely to be a risk allele in the development of aneurysm in patients with KD. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
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