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1. Novel Synthesis of Impurity A, B, and C of Antidepressant Drug Trazodone.

Author

RANE, R. A., SURYAWANSHI, M. R., BABHULKAR, G. V., KHOBRAGADE, P. D., PATIL, R. K., MALE, R. D., CHINDHE, S. A., and PAWAR, D. K.

Subjects
TRAZODONE, SEROTONIN antagonists, ANTIDEPRESSANTS, SEROTONIN receptors, VENLAFAXINE
Abstract

Trazodone is a triazolopyridine analogue from the antidepressant class of serotonin receptor antagonists and reuptake inhibitors (SARIs). In the API and finished product of Trazodone impurity A, B and C are observed regularly. The present work discloses the first synthesis of these impurities with good to excellent yield and purity. [ABSTRACT FROM AUTHOR]

Published
2023
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