1. [Prevention of deteriorations of blood biochemical indices in experimental stress in rats].
- Author
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Momot TV, Kushnerova NF, and Rakhmanin YA
- Subjects
- Animals, Cholesterol blood, Organ Size, Rats, Stress, Physiological drug effects, Stress, Physiological physiology, Superoxide Dismutase metabolism, Treatment Outcome, Triglycerides blood, Adrenal Glands pathology, General Adaptation Syndrome blood, General Adaptation Syndrome etiology, General Adaptation Syndrome therapy, Lipid Metabolism drug effects, Phytotherapy methods, Plant Extracts pharmacology, Viburnum
- Abstract
Results of the research of the impact of extract from the byproducts of guelder-rose, containing a complexflavonoides (65% of dry weight), in the conditions of experimental a stress (vertical fixing of rats by a dorsal cervicalfold for 22 o’clock) are presented. The impact of a stress was shown to be followed by the gain in mass of adrenal glands by 42%. In blood serum there were noted marked hypertriglyceridemia, hypercholesterolemia, increased superoxide dismutase activity, decline in the number of reduced glutathione and anti-radical activity, the gain in lisofractions of phospholipids, decrease of phosphatidylcholine, phosphatidylethanolamine, cholesterol esters. Administration of the extract from the byproducts of guelder rose crushing promoted the normalization of indices of mass of adrenal glands and lipid metabolism in blood serum, was more effective, than a reference stress protector “Extract eleuterokokka®”. The introduction of eleuterococcus was followed by the persistent both elevated level of cholesterol, free fatty acids, lisofraction of phospholipidsand low level offatty acids esters, cholesterol esters and a diphosphatidilglicerin. Byproducts of guelder-rose were shown to represent a perspective view of raw materials for the producing of stress protective preparations.
- Published
- 2016