1. Rapid innate control of antigen abrogates adaptive immunity.
- Author
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Pembroke TP, Gallimore AM, and Godkin A
- Subjects
- Animals, CD4-Positive T-Lymphocytes pathology, CD4-Positive T-Lymphocytes virology, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes pathology, CD8-Positive T-Lymphocytes virology, Cytokines biosynthesis, Cytokines immunology, Dendritic Cells immunology, Dendritic Cells pathology, Dendritic Cells virology, Humans, Immunologic Memory, Killer Cells, Natural pathology, Killer Cells, Natural virology, Mice, Models, Immunological, Virus Diseases pathology, Virus Diseases virology, Viruses immunology, Adaptive Immunity, Antigens, Viral immunology, CD4-Positive T-Lymphocytes immunology, Immunity, Innate, Killer Cells, Natural immunology, Virus Diseases immunology
- Abstract
Natural killer (NK) cells provide an immediate first line of defence against viral infections. Memory responses, maintained by CD4(+) T cells, require exposure to viral antigen and provide long-term protection against future infections. It is known that NK cells can promote the development of the adaptive response through cytokine production and cross-talk with antigen-presenting cells. In this paper however, we summarize a series of recent publications, in mouse models and for the first time in man, with the unifying message that rapid viral antigen control by the innate immune system limits antigen exposure to CD4(+) cells thereby abrogating the development of a memory response. We discuss the significant implication of these studies on viral treatment strategies and immunization models., (© 2012 Blackwell Publishing Ltd.)
- Published
- 2013
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