1. Apigenin's Therapeutic Potential Against Viral Infection.
- Author
-
Lee IG, Lee J, Hong SH, and Seo YJ
- Subjects
- Humans, Apigenin pharmacology, Apigenin therapeutic use, Apigenin chemistry, Flavonoids, Antiviral Agents pharmacology, Antiviral Agents therapeutic use, Virus Diseases drug therapy, Neoplasms drug therapy
- Abstract
Several antiviral drugs are clinically approved to treat influenza that is a highly prevalent acute respiratory disease. However, emerging drug-resistant virus strains undermine treatment efficacy, highlighting the exigency for novel antiviral drugs to counter these drug-resistant strains. Plants and their derivates have been historically utilized as medicinal remedies, and extensive studies have evidenced the antiviral potential of phytochemicals. Notably, apigenin is a predominant flavonoid with minimal toxicity and substantial therapeutic effects in various disease models. Despite its many anti-inflammatory, anti-oxidant, anti-cancer, anti-bacterial, and other beneficial bioactivities, existing reviews have yet to focus on apigenin's antiviral effects. Therefore, this review elucidates apigenin's therapeutic and antiviral properties in vitro and in vivo , discussing its mode of action and future prospects. Apigenin's remarkable inhibition by modulating multiple mechanisms against viruses has promising potential for novel plant-derived antiviral drugs and further clinical study developments., Competing Interests: The authors declare no conflict of interest., (© 2023 The Author(s). Published by IMR Press.)
- Published
- 2023
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