24 results on '"Plant, Gordon T."'
Search Results
2. Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen: A Comparison of Cases with and without Visual Field Loss.
- Author
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Traber GL, Weber KP, Sabah M, Keane PA, and Plant GT
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- Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Visual Acuity, Visual Field Tests, Optic Disk diagnostic imaging, Optic Disk Drusen diagnostic imaging, Optic Disk Drusen physiopathology, Tomography, Optical Coherence methods, Vision Disorders physiopathology, Visual Fields physiology
- Abstract
Purpose: Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD OCT) has been recognized as the most sensitive tool to diagnose optic nerve head drusen (ONHD). The relationship between OCT characteristics and visual loss has not been well documented. This study compares EDI SD OCT-determined morphologic characteristics of drusen in eyes with or without visual field (VF) defects., Design: Descriptive study of patients attending the neuro-ophthalmology service of Moorfields Eye Hospital between January 2013 and October 2014., Subjects: Patients with diagnosed ONHD and EDI SD OCT imaging of the optic nerve head., Methods: Eyes with and without VF defects were compared with regard to retinal nerve fiber layer (RNFL) thickness, drusen morphology, size, extent, visibility on funduscopy, ultrasound, and fundus autofluorescence., Main Outcome Measures: Difference in OCT characteristics of ONHD between patients with or without VF defects., Results: Of 38 patients, 69 eyes with ONHD were included. Thirty-three eyes had a normal VF with average mean deviation (MD) -0.96 (±1.2) dB and pattern standard deviation (PSD) 1.6 (±0.3) dB (group I), and 36 eyes had VF defects with MD -13.7 (±10.4) dB and PSD 7.2 (±3.6) dB (group II). Mean global RNFL thickness was 62 (±20.9) μm in the latter group and 99.0 (±12.9) μm in group I. In group I, the predominant drusen type was peripapillary drusen, of variable size. In group II, most eyes had confluent (P < 0.02) and large (>500 μm; P < 0.003) drusen, and drusen were more commonly visible on funduscopy (P = 0.001), ultrasound (P = 0.013), and autofluorescence (P = 0.002). Differences between the 2 groups reached statistical significance in a clustered analysis. RNFL thinning and autofluorescence showed relative sparing of the temporal sector. Sixty-four percent of patients with a VF defect in 1 eye also had a VF defect in their fellow eye., Conclusions: Drusen size and drusen type as classified by OCT morphologic characteristics are significantly different in patients with or without VF defects. Confluent, large, and autofluorescent drusen were more commonly found in patients with VF defects. These findings may assist in clarifying how drusen give rise to visual loss, which is currently not known., (Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
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- 2017
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3. Visual snow: A thalamocortical dysrhythmia of the visual pathway?
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Lauschke JL, Plant GT, and Fraser CL
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- Adolescent, Adult, Cerebral Cortex physiopathology, Color Vision, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Syndrome, Thalamus physiopathology, Tinnitus diagnosis, Tremor diagnosis, Migraine Disorders diagnosis, Vision Disorders diagnosis, Visual Pathways physiopathology
- Abstract
In this paper we review the visual snow (VS) characteristics of a case cohort of 32 patients. History of symptoms and associated co-morbidities, ophthalmic examination, previous investigations and the results of intuitive colourimetry were collected and reviewed. VS symptoms follow a stereotypical description and are strongly associated with palinopsia, migraine and tinnitus, but also tremor. The condition is a chronic one and often results in misdiagnosis with psychiatric disorders or malingering. Colour filters, particularly in the yellow-blue colour spectrum, subjectively reduced symptoms of VS. There is neurobiological evidence for the syndrome of VS that links it with other disorders of visual and sensory processing such as migraine and tinnitus. Colour filters in the blue-yellow spectrum may alter the koniocellular pathway processing, which has a regulatory effect on background electroencephalographic rhythms, and may add weight to the hypothesis that VS is a thalamocortical dysrhythmia of the visual pathway., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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4. Photopsia and a temporal visual field defect.
- Author
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Marsiglia M, Odel JG, Rudich DS, Tsang SH, and Plant GT
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- Adult, Electrooculography, Electroretinography, Female, Humans, Tomography, Optical Coherence, Visual Field Tests, Eye Abnormalities diagnosis, Eye Diseases diagnosis, Optic Disk abnormalities, Vision Disorders diagnosis, Visual Fields, Vitreous Body pathology
- Abstract
A 30-year-old woman presented with intermittent photopsia, a temporal visual field defect below the horizontal in her left eye, and flu-like symptoms. Slit-lamp and fundus examinations were unremarkable. Humphrey 30-2 threshold perimetry and 120-point screening visual field demonstrated blind spot enlargement of the left eye and a normal field in the right eye. Fundus autofluorescence, optical coherence tomography of the macula, full-field electroretinogram, electrooculogram, and multifocal electroretinogram were normal. Swept-source optical coherence tomography scan of the left optic nerve showed an intact outer retina, a remarkably thinned nerve fiber layer nasally, and peripapillary vitreous traction. Goldmann kinetic perimetry revealed a sector-shaped dense defect breaking out from the blind spot to the temporal periphery just below the horizontal in the left eye. The patient had nasal hypoplasia of the optic nerve and peripapillary vitreous traction., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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5. Autoimmunity in visual loss.
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Petzold A, Wong S, and Plant GT
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- Autoantibodies metabolism, Autoimmune Diseases immunology, Humans, Myelin-Oligodendrocyte Glycoprotein immunology, Vision Disorders immunology, Autoimmune Diseases complications, Vision Disorders complications
- Abstract
There are a number of autoimmune disorders which can affect visual function. There are a very large number of mechanisms in the visual pathway which could potentially be the targets of autoimmune attack. In practice it is the retina and the anterior visual pathway (optic nerve and chiasm) that are recognised as being affected in autoimmune disorders. Multiple Sclerosis is one of the commonest causes of visual loss in young adults because of the frequency of attacks of optic neuritis in that condition, however the basis of the inflammation in Multiple Sclerosis and the confirmation of autoimmunity is lacking. The immune process is known to be highly unusual in that it is not systemic and confined to the CNS compartment. Previously an enigmatic partner to Multiple Sclerosis, Neuromyelitis Optica is now established to be autoimmune and two antibodies - to Aquaporin4 and to Myelin Oligodendrocyte Glycoprotein - have been implicated in the pathogenesis. The term Chronic Relapsing Inflammatory Optic Neuropathy is applied to those cases of optic neuritis which require long term immunosuppression and hence are presumed to be autoimmune but where no autoimmune pathogenesis has been confirmed. Optic neuritis occurring post-infection and post vaccination and conditions such as Systemic Lupus Erythematosus and various vasculitides may cause direct autoimmune attack to visual structures or indirect damage through occlusive vasculopathy. Chronic granulomatous disorders such as Sarcoidosis affect vision commonly by a variety of mechanisms, whether and how these are placed in the autoimmune panoply is unknown. As far as the retina is concerned Cancer Associated Retinopathy and Melanoma Associated Retinopathy are well characterised clinically but a candidate autoantibody (recoverin) is only described in the former disorder. Other, usually monophasic, focal retinal inflammatory disorders (Idiopathic Big Blind Spot Syndrome, Acute Zonal Occult Outer Retinopathy and Acute Macular Neuroretinitis) are of obscure pathogenesis but an autoimmune disorder of the post-infectious type is plausible. Visual loss in autoimmunity is an expanding field: the most significant advances in research have resulted from taking a well characterised phenotype and making educated guesses at the possible molecular targets of autoimmune attack., (© 2016 Elsevier B.V. All rights reserved.)
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- 2016
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6. Severe, persistent visual impairment associated with occipital calcification and coeliac disease.
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Millington RS, James-Galton M, Barbur JL, Plant GT, and Bridge H
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- Brain Diseases complications, Brain Diseases physiopathology, Calcinosis complications, Calcinosis physiopathology, Celiac Disease complications, Celiac Disease physiopathology, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Occipital Lobe physiopathology, Vision Disorders etiology, Vision Disorders physiopathology, White Matter pathology, Brain Diseases pathology, Calcinosis pathology, Celiac Disease pathology, Occipital Lobe pathology, Vision Disorders pathology
- Abstract
While coeliac disease is primarily a disease of the digestive system, there have been several reports of neurological effects, both motor and cognitive. Here, we present the case of a woman with coeliac disease, under dietary control, in whom there is profound long-standing visual disturbance including reduction of visual fields, loss of rapid flicker and colour sensitivity and severe deficits in acuity. Structural magnetic resonance imaging (MRI) indicates large regions of calcification and abnormal tissue that is restricted to the occipital cortex, particularly the posterior region. Functional MRI indicates an absence of normal visual activation in the primary visual cortex, but at least in one hemisphere, there is neural activity to moving stimuli in visual motion area hMT+. White matter microstructure in the pathway between the lateral geniculate nucleus and hMT+ is normal compared to healthy control subjects, but is severely abnormal between the lateral geniculate nucleus and primary visual cortex. This case study illustrates the very specific nature of cortical deficit that can arise in association with coeliac disease, and highlights the importance of early dietary control for the disease.
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- 2015
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7. Is the 'Act FAST' stroke campaign lobeist? The implications of including symptoms of occipital lobe and eye stroke in public education campaigns.
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Lawlor M, Perry R, and Plant GT
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- Abbreviations as Topic, Brain Diseases etiology, Health Promotion methods, Humans, Occipital Lobe, Stroke complications, Stroke therapy, Health Education methods, Stroke diagnosis, Vision Disorders etiology
- Published
- 2015
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8. Strokes and vision: The management of ischemic arterial disease affecting the retina and occipital lobe.
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Lawlor M, Perry R, Hunt BJ, and Plant GT
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- Aspirin therapeutic use, Endarterectomy, Carotid, Humans, Ischemic Attack, Transient diagnosis, Ophthalmologic Surgical Procedures, Retinal Artery Occlusion diagnosis, Stroke diagnosis, Stroke physiopathology, Tissue Plasminogen Activator, Vision Disorders diagnosis, Vision Disorders physiopathology, Ischemic Attack, Transient therapy, Occipital Lobe pathology, Retinal Artery Occlusion therapy, Stroke therapy, Vision Disorders therapy
- Abstract
Embolic disease of the anterior or posterior vascular territories may lead to disturbance of vision. Although death from this is uncommon, morbidity remains relatively high: Visual field loss may impair or preclude reading and driving and these are important influences on quality of life. Visual symptoms of stroke mean that patients may present to ophthalmologists with isolated visual symptoms, rather than directly to an emergency department. It is important to diagnose stroke and transient ischemic attacks accurately, as well as to manage them appropriately, as they are important harbingers of further cerebrovascular events. Ophthalmologists are therefore well placed to ensure that these patients receive appropriate acute treatment and secondary prevention. This article reviews the evidence for managing patients presenting with visual symptoms of vascular events. It reviews management of ischemic stroke in general, and compares this with management of events involving the anterior circulation by way of transient monocular visual loss or retinal artery occlusion, and posterior circulation by way of transient binocular visual loss or infarction of the visual cortex., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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9. Embolic and nonembolic transient monocular visual field loss: a clinicopathologic review.
- Author
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Petzold A, Islam N, Hu HH, and Plant GT
- Subjects
- Amaurosis Fugax pathology, Carotid Artery, External pathology, Carotid Artery, Internal pathology, Carotid Stenosis etiology, Humans, Incidence, Practice Guidelines as Topic, Retinal Artery Occlusion etiology, Risk Factors, Stroke etiology, Vision Disorders pathology, Amaurosis Fugax etiology, Embolism complications, Retinal Vessels pathology, Vision Disorders etiology, Visual Fields
- Abstract
Transient monocular blindness and amaurosis fugax are umbrella terms describing a range of patterns of transient monocular visual field loss (TMVL). The incidence rises from ≈1.5/100,000 in the third decade of life to ≈32/100,000 in the seventh decade of life. We review the vascular supply of the retina that provides an anatomical basis for the types of TMVL and discuss the importance of collaterals between the external and internal carotid artery territories and related blood flow phenomena. Next, we address the semiology of TMVL, focusing on onset, pattern, trigger factors, duration, recovery, frequency-associated features such as headaches, and on tests that help with the important differential between embolic and non-embolic etiologies., (Copyright © 2013 Elsevier Inc. All rights reserved.)
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- 2013
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10. Transient visual loss after seizures.
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Subash M, Sheth HG, Saihan Z, and Plant GT
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- Adult, Female, Humans, Male, Young Adult, Epilepsy, Generalized complications, Epilepsy, Tonic-Clonic complications, Vision Disorders etiology
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- 2010
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11. 'Hemispherical asymmetry in the Meyer's Loop': a prospective study of visual-field deficits in 105 cases undergoing anterior temporal lobe resection for epilepsy.
- Author
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Jeelani NU, Jindahra P, Tamber MS, Poon TL, Kabasele P, James-Galton M, Stevens J, Duncan J, McEvoy AW, Harkness W, and Plant GT
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- Adult, Anterior Temporal Lobectomy methods, Epilepsy, Temporal Lobe surgery, Humans, Magnetic Resonance Imaging, Middle Aged, Prospective Studies, Anterior Temporal Lobectomy adverse effects, Epilepsy, Temporal Lobe physiopathology, Functional Laterality physiology, Vision Disorders physiopathology, Visual Fields physiology, Visual Pathways physiopathology
- Abstract
Objectives: Visual-field deficits following temporal lobe surgery have been reported in the literature. In this prospective study, the authors analyse their experience of visual-field deficits in 105 consecutive cases undergoing temporal-lobe surgery performed by a single surgeon, with particular consideration to the laterality of the deficit and its functional implications., Methods: 105 consecutive patients undergoing an anterior temporal lobe resection for epilepsy, between March 1998 and June 2004, were selected. The patient population had a mean age of 35 years (range 19-60 years); 53 had a left-sided resection and 52 a right-sided resection. 91 patients had mesial temporal sclerosis, three gangliogliomas, four dysembryoplastic neuroepithelial tumours (DNETs), two neurocytomas and two cavernomas, and in three cases the histology was inconclusive. Pre- and postoperative visual-field tests were obtained using the Humphrey Esterman binocular functional test for all cases. The test was set to stimulus white III, with a single intensity of 10 DB on the background of 31.5 ASB for all patients. A minimum follow-up period of 12 months postsurgery was employed. Postoperative MRI scans were carried out on all patients. 60 scans were randomly selected, and the extent of temporal lobe resection calculated manually for each., Results: Of the 105 cases, 16 patients had a visual-field deficit postoperatively which was not present preoperatively: 12 following a left and four following a right-sided resection. The OR for incurring a postoperative visual-field defect following left versus right-sided surgery was 3.51 (95% CI 1.05 to 11.73, p=0.04). In four patients, the deficit was severe enough to preclude them from driving in the UK (three left- and one right-sided resection). There was no association between the extent of tissue resection and the incidence of postoperative visual-field deficits., Conclusions: This study suggests left-/right-hemispherical asymmetry in the Geniculocalcarine tracts with field deficits being 3.5 times more likely following left-sided anterior temporal lobe resections compared with right-sided resections. This has significant implications on counselling patients for these procedures. MR tractography may provide an anatomical substrate for these clinical findings, perhaps revealing a more anterior course of the optic radiations within the temporal lobe in one hemisphere versus the other.
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- 2010
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12. Neuroplasticity predicts outcome of optic neuritis independent of tissue damage.
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Jenkins TM, Toosy AT, Ciccarelli O, Miszkiel KA, Wheeler-Kingshott CA, Henderson AP, Kallis C, Mancini L, Plant GT, Miller DH, and Thompson AJ
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- Adult, Axons pathology, Axons physiology, Brain pathology, Brain physiopathology, Demyelinating Diseases pathology, Demyelinating Diseases physiopathology, Evoked Potentials, Visual, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Optic Nerve pathology, Optic Nerve physiopathology, Optic Neuritis pathology, Prognosis, Time Factors, Tomography, Optical Coherence, Vision Disorders pathology, Visual Pathways pathology, Visual Pathways physiopathology, Young Adult, Neuronal Plasticity, Optic Neuritis diagnosis, Optic Neuritis physiopathology, Vision Disorders diagnosis, Vision Disorders physiopathology
- Abstract
Objectives: To determine whether lateral occipital complex (LOC) activation with functional magnetic resonance imaging (fMRI) predicts visual outcome after clinically isolated optic neuritis (ON). To investigate the reasons behind good recovery following ON, despite residual optic nerve demyelination and neuroaxonal damage., Methods: Patients with acute ON and healthy volunteers were studied longitudinally over 12 months. Structural MRI, visual evoked potentials (VEPs), and optical coherence tomography (OCT) were used to quantify acute inflammation, demyelination, conduction block, and later to estimate remyelination and neuroaxonal loss over the entire visual pathway. The role of neuroplasticity was investigated using fMRI. Multivariable linear regression analysis was used to study associations between vision, structure, and function., Results: Greater baseline fMRI responses in the LOCs were associated with better visual outcome at 12 months. This was evident on stimulation of either eye (p = 0.007 affected; p = 0.020 fellow eye), and was independent of measures of demyelination and neuroaxonal loss. A negative fMRI response in the LOCs at baseline was associated with a relatively worse visual outcome. No acute electrophysiological or structural measures, in the anterior or posterior visual pathways, were associated with visual outcome., Interpretation: Early neuroplasticity in higher visual areas appears to be an important determinant of recovery from ON, independent of tissue damage in the anterior or posterior visual pathway, including neuroaxonal loss (as measured by MRI, VEP, and OCT) and demyelination (as measured by VEP).
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- 2010
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13. Risk factors for early visual deterioration in temporal arteritis.
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Loddenkemper T, Sharma P, Katzan I, and Plant GT
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- Adrenal Cortex Hormones therapeutic use, Aged, Aged, 80 and over, Biopsy, Disease Progression, Dose-Response Relationship, Drug, Female, Giant Cell Arteritis drug therapy, Giant Cell Arteritis pathology, Humans, Hypertension complications, Hypertension diagnosis, Male, Middle Aged, Papilledema diagnosis, Papilledema drug therapy, Papilledema pathology, Retrospective Studies, Risk Factors, Temporal Arteries pathology, Vision Disorders drug therapy, Vision Disorders pathology, Visual Acuity drug effects, Giant Cell Arteritis diagnosis, Vision Disorders diagnosis
- Abstract
Background: Despite corticosteroid treatment, patients with temporal arteritis may continue to lose vision. However, predictors of progressive visual loss are not known., Methods: We retrospectively reviewed 341 consecutive patients with suspected temporal arteritis who underwent temporal artery biopsy. 90 patients with biopsy proven temporal arteritis were included in our study., Results: Twenty-one patients (23%) experienced continuous visual symptoms despite steroid therapy and 14 among these suffered persistent visual deterioration. Based on univariate analysis, visual loss on presentation was associated with disc swelling and a history of hypertension. Risk factors for progressive visual loss included older age, elevated C reactive protein and disc swelling., Conclusion: Although corticosteroid therapy improves the visual prognosis in temporal arteritis, steroids may not stop the progression of visual loss. Our study reliably establishes the risk factors for visual loss in this serious condition. Whether addressing these risk factors early in their presentation can alter the visual outcome remains unknown. Individual risk anticipating treatment regimens and strategies might improve the visual prognosis in temporal arteritis in the future.
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- 2007
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14. Clinical disorders affecting mesopic vision.
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Petzold A and Plant GT
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- Electroretinography methods, Fluorescein Angiography, Humans, Macular Degeneration physiopathology, Melanoma physiopathology, Night Blindness genetics, Retinal Diseases genetics, Retinal Diseases physiopathology, Retinitis genetics, Retinitis Pigmentosa genetics, Syndrome, Vision Disorders genetics, Vision Tests methods, Vitamin A Deficiency physiopathology, Retinal Cone Photoreceptor Cells physiopathology, Retinal Rod Photoreceptor Cells physiopathology, Vision Disorders physiopathology
- Abstract
Vision in the mesopic range is affected by a number of inherited and acquired clinical disorders. We review these conditions and summarize the historical background, describing the clinical characteristics alongside the genetic basis and molecular biological mechanisms giving rise to rod and cone dysfunction relevant to twilight vision. The current diagnostic gold standards for each disease are discussed and curative and symptomatic treatment strategies are summarized.
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- 2006
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15. Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis.
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Trip SA, Schlottmann PG, Jones SJ, Altmann DR, Garway-Heath DF, Thompson AJ, Plant GT, and Miller DH
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- Adult, Evoked Potentials, Visual physiology, Female, Humans, Male, Middle Aged, Optic Neuritis pathology, Retinal Ganglion Cells pathology, Tomography, Optical Coherence, Vision Disorders pathology, Visual Acuity physiology, Axons pathology, Nerve Fibers pathology, Optic Neuritis physiopathology, Retina pathology, Vision Disorders physiopathology
- Abstract
Axonal loss is thought to be a likely cause of persistent disability after a multiple sclerosis relapse; therefore, noninvasive in vivo markers specific for axonal loss are needed. We used optic neuritis as a model of multiple sclerosis relapse to quantify axonal loss of the retinal nerve fiber layer (RNFL) and secondary retinal ganglion cell loss in the macula with optical coherence tomography. We studied 25 patients who had a previous single episode of optic neuritis with a recruitment bias to those with incomplete recovery and 15 control subjects. Optical coherence tomography measurement of RNFL thickness and macular volume, quantitative visual testing, and electrophysiological examination were performed. There were highly significant reductions (p < 0.001) of RNFL thickness and macular volume in affected patient eyes compared with control eyes and clinically unaffected fellow eyes. There were significant relationships among RNFL thickness and visual acuity, visual field, color vision, and visual-evoked potential amplitude. This study has demonstrated functionally relevant changes indicative of axonal loss and retinal ganglion cell loss in the RNFL and macula, respectively, after optic neuritis. This noninvasive RNFL imaging technique could be used in trials of experimental treatments that aim to protect optic nerves from axonal loss.
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- 2005
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16. Anticholinergic syndrome: blurred vision and headache.
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McAnena, Lisa, Plant, Gordon T., and Sui Hsien Wong
- Subjects
- *
PARASYMPATHOMIMETIC agents , *NORTRIPTYLINE (Drug) , *QUETIAPINE , *PUPIL diseases , *TREATMENT effectiveness , *VISUAL acuity , *VISION disorders , *HEADACHE - Abstract
A young woman presented with blurred vision due to anticholinergic syndrome. We highlight the importance of considering this condition in the context of multiple medications and increased anticholinergic burden. The documented pupil abnormality gives an opportunity to review the syndrome of the reverse (inverse) Argyll Robertson pupil (preserved pupil light response with loss of accommodation). We review other situations in which the reverse Argyll Robertson pupil may occur and its possible mechanism in this case. [ABSTRACT FROM AUTHOR]
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- 2023
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17. In Wagner's Eyes: Casting Light on a Disputed Portrait.
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Trimble, Michael, Hesdorffer, Dale C., Letellier, Robert, and Plant, Gordon T.
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PORTRAITS ,BUSTS ,VISION disorders - Published
- 2019
18. The retinex of colour vision impairment.
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Plant, Gordon T.
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COLOR vision , *VISION disorders , *PALETTE (Color range) , *VISUAL pathways , *VISUAL cortex - Abstract
The concept of the "Retinex" was introduced by Edwin Land in 1962. The aim of his theory of colour vision was to highlight the observations on colour perception that were at odds with the simple "Newtonian" concept that the colours that humans perceive when viewing narrow band light are directly related to perceived colours in the environment. There are, however, two particular observations which are at odds with this simple interpretation of the colours seen in the "spectrum" of light. One was emphasized by Gӧethe in his colour theory: namely that there are a range of named colours that are influenced by the luminance contrast (e.g. brown which is a darkened orange) or closeness of the colour to white. This was explored by Chevreul, Munsell and others who developed systems of colour based on the three dimensions: hue (colour category), saturation (closeness to white) and value (brightness). The second was the observation studied extensively by Land: namely that colours remain constant across a certain range despite a change in the spectral content of the illuminant. Thus despite a change in the pattern of cone excitation the colour appearance does not change. Land also emphasized that this phenomenon is influenced by other colours in the scene and introduced the study of natural scenes with natural illumination rather than narrow band light in the laboratory. So in this context Land decided to refer to the "Retinex" as it was clear that the various processes were taking place both at the retinal and cortical levels. I am adopting this term in my talk because clinical studies provide an opportunity to study the influence of damage at all levels in the visual pathway on colour perception. Beginning with congenital colour anomalies affecting the cone opsins all the way to damage to extra‐striate visual cortex clinical studies, such as those presented in this symposium, alterations in colour vision provide an insight into how damage at various levels in the "Retinex" influence colour perception. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Idiopathic Acquired Temporal Wedge Visual Field Defects.
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Gilhooley, Michael J., Fraser, Clare L., Wong, Sui, Hickman, Simon J., and Plant, Gordon T.
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SCOTOMA ,VISION disorders ,TEMPORAL lobe diseases ,OPTIC disc ,SURGICAL complications ,DIAGNOSIS ,DISEASES - Abstract
Our aim is to report 13 unusual cases of acquired, temporal sectoral scotomas. Such stationary “wedge” field defects have been reported previously in cases of presumedcongenitalnasal hypoplasia of the optic disc and as a complication of vitreoretinal surgery. To our knowledge, the literature provides no reports of similar defects occurring spontaneously. This is a descriptive clinical case series of 13 patients presenting with sub-acute monocular temporal visual field loss. All were clinically assessed and investigated with Goldmann perimetry, automated Humphrey visual fields, retinal optical coherence tomography, orbital ultrasound, and standard and multi-focal electroretinography. Cases were followed with serial perimetry for a mean of 3.9 years (range: 6 months to 10 years). Goldmann and Humphrey perimetry both demonstrated “wedge”-shaped defects extending temporally from an apex contiguous with, or lateral to, the blind spot. There was no evidence of optic disc drusen, glaucoma, disc hypoplasia, or focal retinitis. Sectoral optic disc swelling was not present in any patient at presentation. In all cases, the visual field defect remained stable. One patient developed a similar defect in the fellow eye after an interval of 5 years. Here we describe 13 cases of acquired, stationary temporal wedge scotomas, novel in the literature. Although the aetiology is uncertain, we propose damage to the nasal rim of the optic disc as a likely mechanism. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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20. Thinning of the Retinal Nerve Fibre Layer in Homonymous Quadrantanopia: Further Evidence for Retrograde Trans-Synaptic Degeneration in the Human Visual System.
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Jindahra, Panitha, Petrie, Aviva, and Plant, Gordon T.
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CROSS-sectional method ,EYE diseases ,DEGENERATION (Pathology) ,OPTICAL coherence tomography ,NERVE fibers ,VISION disorders ,PATIENTS - Abstract
This investigation is a cross-sectional study of peripapillary retinal nerve fibre layer (RNFL) thickness in a cohort of homonymous quadrantanopia (HQ) patients with evidence of post-geniculate pathology. Forty-four cases were recruited and divided into three groups; 14 acquired HQ cases; 7 congenital HQ cases; and lastly 23 control individuals. Compared with the controls, RNFL thinning was most obvious at the superior sector in inferior quadrantanopia and at the inferior sector in superior quadrantanopia as would be expected from the known fibre trajectories. The findings are likely to reflect retrograde trans-synaptic degeneration in cases of post-geniculate damage lesser in extent than those previously studied. A further analysis was carried out comparing RNFL thickness (overall, mean of the two eyes) with the Humphrey mean deviation score (mean of the two eyes). For this analysis, data of an additional 28 patients with dense homonymous hemianopia and three cases with sub-quadrantic homonymous scotoma were also included. A statistically significant straight line relationship was found ( r = 0.5, p < 0.001), indicating a strong correlation between the RNFL thinning and the visual deficit. [ABSTRACT FROM AUTHOR]
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- 2012
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21. The Diagnostic and Prognostic Value of Neurofilament Heavy Chain Levels in Immune-Mediated Optic Neuropathies.
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Petzold, Axel and Plant, Gordon T.
- Subjects
- *
OPTIC nerve diseases , *CYTOPLASMIC filaments , *VISION disorders , *AXONS , *NEURODEGENERATION , *ENZYME-linked immunosorbent assay , *HEALTH outcome assessment , *DISEASE relapse , *DIAGNOSIS - Abstract
Background. Loss of visual function differs between immune-mediated optic neuropathies and is related to axonal loss in the optic nerve. This study investigated the diagnostic and prognostic value of a biomarker for neurodegeneration, the neurofilament heavy chain (NfH) in three immune-mediated optic neuropathies. Methods. A prospective, longitudinal study including patients with optic neuritis due to multiple sclerosis (MSON, n = 20), chronic relapsing inflammatory optic neuritis (CRION, n = 19), neuromyelitis optica (NMO, n = 9), and healthy controls (n = 28). Serum NfH-SMI35 levels were quantified by ELISA. Findings. SerumNfH-SMI35 levels were highest in patients with NMO (mean 0.79±1.51 ng/mL) compared to patients with CRION (0.13± 0.16 ng/mL, P = 0.007), MSON (0.09 ± 0.09, P = 0.008), and healthy controls (0.01 ± 0.02 ng/mL, P = 0.001). High serum NfHSMI35 levels were related to poor visual outcome. Conclusions. Blood NfH-SMI35 levels are of moderate diagnostic and more important prognostic value in immune-mediated optic neuropathies. We speculate that longitudinal blood NfH levels may help to identify particular disabling events in relapsing conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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22. A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials.
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Henderson, Andrew P. D., Altmann, Daniel R., Trip, Anand S., Kallis, Constantinos, Jones, Steve J., Schlottmann, Patricio G., Garway-Heath, David F., Plant, Gordon T., and Miller, David H.
- Subjects
OPTIC neuritis ,OPTICAL coherence tomography ,VISUAL evoked response ,NERVE fibers ,VISION disorders ,PATIENTS - Abstract
Following an episode of optic neuritis, thinning of the retinal nerve fibre layer, which indicates axonal loss, is observed using optical coherence tomography. The longitudinal course of the retinal changes has not been well characterized. We performed a serial optical coherence tomography study in patients presenting with optic neuritis in order to define the temporal evolution of retinal nerve fibre layer changes and to estimate sample sizes for proof-of-concept trials of neuroprotection using retinal nerve fibre layer loss as the outcome measure. Twenty-three patients (7 male, 16 female, mean age 31 years) with acute clinically isolated unilateral optic neuritis were recruited to undergo optical coherence tomography, visual assessments and visual evoked potentials at presentation (median 16 days from onset of visual loss) and after 3, 6, 12 and 18 months. Compared with the clinically unaffected fellow eye, the retinal nerve fibre layer thickness of the affected eye was significantly increased at presentation and significantly reduced at all later time points. The evolution of retinal nerve fibre layer changes in the affected eye fitted well with an exponential model, with thinning appearing a mean of 1.6 months from symptom onset and the rate of ongoing retinal nerve fibre layer loss decreasing thereafter. At presentation, increased retinal nerve fibre layer thickness was associated with impaired visual acuity and prolonged visual evoked potential latency. Visual function after 12 months was not related to the extent of acute retinal nerve fibre layer swelling but was significantly associated with the extent of concurrent retinal nerve fibre layer loss. Sample size calculations for placebo-controlled trials of acute neuroprotection indicated that the numbers needed after 6 months of follow up are smaller than those after 3 months and similar to those after 12 months of follow-up. Study power was greater when investigating differences between clinically unaffected and affected eyes rather than retinal nerve fibre layer thickness of the affected eye alone. Inflammation in the optic nerve and impaired axonal transport (implied by retinal nerve fibre layer swelling) are associated with visual dysfunction and demyelination (long visual evoked potential latency) during acute optic neuritis. Retinal nerve fibre layer thinning is usually evident within 3 months. Optical coherence tomography-measured retinal nerve fibre layer loss after 6 months is a suitable outcome measure for proof-of-concept trials of acute neuroprotection in optic neuritis. [ABSTRACT FROM PUBLISHER]
- Published
- 2010
- Full Text
- View/download PDF
23. Medical treatment of nystagmus and its visual consequences.
- Author
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Stahl, John S., Plant, Gordon T., and Leigh, R. John
- Subjects
NYSTAGMUS ,OCULAR pharmacology ,VISION disorders ,EYE movement disorders ,THERAPEUTICS - Abstract
The article discusses the treatment of nystagmus and its effects on vision in Great Britain. This disorder is a repetitive involuntary eye movements started by slow drifts of the eye. It consists of alternation of unidirectional drifts away and corrective fast movements which bring the visual target back to the central part (fovea). The improving knowledge of the pharmacology of the ocular motor system may provide clues leading to new drug strategies.
- Published
- 2002
- Full Text
- View/download PDF
24. Photophobia in migraine: A symptom cluster?
- Author
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Wilkins, Arnold J, Haigh, Sarah M, Mahroo, Omar A, and Plant, Gordon T
- Subjects
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RETINAL ganglion cells , *MIGRAINE , *MIGRAINE aura , *CLUSTER headache , *SYMPTOMS , *LIGHT intensity , *MIGRAINE diagnosis , *RESEARCH , *RETINA , *SYNDROMES , *RESEARCH methodology , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies , *VISION disorders - Abstract
Photophobia is one of the most common symptoms in migraine, and the underlying mechanism is uncertain. The discovery of the intrinsically-photosensitive retinal ganglion cells which signal the intensity of light on the retina has led to discussion of their role in the pathogenesis of photophobia. In the current review, we discuss the relationship between pain and discomfort leading to light aversion (traditional photophobia) and discomfort from flicker, patterns, and colour that are also common in migraine and cannot be explained solely by the activity of intrinsically-photosensitive retinal ganglion cells. We argue that, at least in migraine, a cortical mechanism provides a parsimonious explanation for discomfort from all forms of visual stimulation, and that the traditional definition of photophobia as pain in response to light may be too restrictive. Future investigation that directly compares the retinal and cortical contributions to photophobia in migraine with that in other conditions may offer better specificity in identifying biomarkers and possible mechanisms to target for treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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