1. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF THE FOVEAL AVASCULAR ZONE IN CHILDREN WITH A HISTORY OF TREATMENT-REQUIRING RETINOPATHY OF PREMATURITY.
- Author
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Nonobe N, Kaneko H, Ito Y, Takayama K, Kataoka K, Tsunekawa T, Matsuura T, Suzumura A, Shimizu H, and Terasaki H
- Subjects
- Adolescent, Adult, Case-Control Studies, Child, Cryosurgery methods, Female, Follow-Up Studies, Fundus Oculi, Humans, Male, Prognosis, Retinopathy of Prematurity surgery, Retrospective Studies, Young Adult, Fluorescein Angiography methods, Fovea Centralis blood supply, Laser Coagulation methods, Retinal Vessels pathology, Retinopathy of Prematurity diagnosis, Tomography, Optical Coherence methods, Visual Acuity
- Abstract
Purpose: To examine the characteristics of the foveal vascular structure of patients with retinopathy of prematurity (ROP) by optical coherence tomography angiography., Methods: Ten patients with a history of laser photocoagulation or cryopexy treatment for Stage 3 (Zone ≥ II) ROP and 10 normal subjects (controls) were included. Foveal avascular zone, vessel density, vessel length, and vascular diameter index were measured by optical coherence tomography angiography using the 3 × 3-mm Early Treatment Diabetic Retinopathy Study (ETDRS) sectors., Results: The median foveal avascular zone values of the patients with ROP and controls were 0.103 mm and 0.260 mm, respectively (P = 0.0025). The medians of the vessel density, vessel length, and vascular diameter index of the patients with ROP were 0.218 mm/mm, 11.75 mm/mm, and 18.00 μm, respectively, in ETDRS Sector 1 and did not significantly differ from those of the controls (P = 0.940, 0.733, and 0.705, respectively). For the average of ETDRS Sectors 2 to 5, the medians of the vessel density, vessel length, and vascular diameter index for the patients with ROP were 0.347 mm/mm, 18.95 mm/mm, and 18.28 μm, respectively; vessel density and vessel length were significantly smaller than those of the controls (P = 0.002 and 0.003, respectively), but there was no significant difference in vascular diameter index (P = 0.286)., Conclusion: Optical coherence tomography angiography-guided foveal avascular zone was significantly smaller in patients with ROP than in controls. Our results indicate that foveal vascular development may be altered in patients with a history of treatment-requiring ROP.
- Published
- 2019
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