1. Prenatal ve emzirme döneminde maruz kalınan tiamin eksikliğinin yetişkinlikte davranış, öğrenme ve hafızaya etkileri.
- Author
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DANIŞMAN, Betül, AKÇAY, Güven, and KANTAR GÖK, Deniz
- Subjects
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VITAMIN B deficiency , *MAZE tests , *ESSENTIAL nutrients , *VITAMIN B1 , *MALNUTRITION , *MEMORY disorders - Abstract
Objective: Thiamine (vitamin B1) is an essential nutrient that acts as a cofactor for many enzymes, especially in the mitochondria. Some thiamine-linked enzymes participate in energy metabolism and the biosynthesis of nucleic acids, while others act as part of the antioxidant mechanism. As the brain is heavily dependent on mitochondrial ATP production, it is highly vulnerable to thiamine deficiency (TD). This effect is more pronounced in prenatal and childhood periods when rapid growth occurs. In this study, behavioral changes in adulthood of TD-induced rats during prenatal and lactation periods were investigated. Methods: In the study, rats were divided into two groups as the group whose mothers were fed a normal diet (NN) and the mothers were fed with thiamine deficient diet (TN) during prenatal and lactation periods. Open Field test, Elevated Plus Maze test and New Object Recognition tests were applied to rats in adulthood. Results: In the thiamine deficient TN group, it was observed that the number of frames entered in the open field test and the rate of time spent in the outer quadrant increased. In addition, in the elevated plus maze test, the ratio of time spent in the open arm in the TN group was decreased. In the new object recognition test, it was determined that the discrimination index was decreased in the TN group. Conclusion: In our study, it was observed that the effects of TD during prenatal and lactation periods can continue in the long term and cause behavioral, learning and memory deficits in the later ages. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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