1. Type IV hypersensitivity to vitamin K.
- Author
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Sommer S, Wilkinson SM, Peckham D, and Wilson C
- Subjects
- Adult, Eczema chemically induced, Female, Humans, Injections, Intramuscular, Molecular Conformation, Patch Tests, Vitamin K analogs & derivatives, Vitamin K chemistry, Dermatitis, Allergic Contact etiology, Vitamin K adverse effects
- Abstract
The day after intramuscular injection of vitamin K1 (phytomenadione) into her thigh, a 27-year-old-woman with normal liver function developed a relapsing and remitting eczematous reaction localized to the injection site, and later a further eczematous reaction under an adhesive dressing (Duoderm). On patch testing, she was positive to vitamin K1 and cross-reacted to vitamin K4; she was also positive to colophonium and to ester gum rosin, the dressing adhesive. Recurrent angioedema persisted for several months and, 2 years later, symptoms were still occurring over the injection sites. Structure-activity relationships among vitamin K allergens are discussed.
- Published
- 2002
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