1. Oculocerebral non-Hodgkin's lymphoma with uveal involvement: development of an epibulbar tumor after vitrectomy.
- Author
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Cursiefen C, Holbach LM, Lafaut B, Heimann K, Kirchner T, and Naumann GO
- Subjects
- Aged, Conjunctival Neoplasms etiology, Eye Enucleation, Female, Glaucoma, Angle-Closure etiology, Humans, Lymphoma, B-Cell etiology, Lymphoma, Large B-Cell, Diffuse etiology, Sclerostomy, Uveal Neoplasms etiology, Uveitis, Anterior complications, Uveitis, Anterior surgery, Brain Neoplasms pathology, Ciliary Body pathology, Conjunctival Neoplasms pathology, Lymphoma, B-Cell pathology, Lymphoma, Large B-Cell, Diffuse pathology, Uveal Neoplasms pathology, Vitrectomy adverse effects
- Abstract
Primary ocular lymphoma is the ocular manifestation of primary oculocerebral non-Hodgkin's lymphoma. We describe a 79-year-old woman with a 7-year history of bilateral uveitis and subsequent central nervous system lymphomas. Repeated diagnostic vitrectomy during the following 5 years failed to demonstrate intraocular lymphoma cells. Within 9 months after the second vitrectomy, an epibulbar tumor developed in the limbal region of the left eye at the site of the sclerotomy. The eye, blind and painful due to secondary angle-closure glaucoma, was enucleated. Histopathologically, the globe showed a diffuse large B-cell non-Hodgkin's lymphoma extending from the ciliary body outward through the sclerotomy. We conclude that, following vitrectomy, a primary ocular lymphoma may extend through the sclerotomy lesion and present as an epibulbar tumor. Uveal involvement may occur in oculocerebral non-Hodgkin's lymphoma.
- Published
- 2000
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