Population growth is increasing the pressure on water resource availability. For useful assessment and planning for societal water availability impacts, it is imperative to disentangle the direct influences of human activities in the landscape from external climate‐driven influences on water flows and their variation and change. In this study we used the water balance model, a gridded global hydrological model, to quantify and distinguish human‐driven change components, modified by interventions such as dams, reservoirs, and water withdrawals for irrigation, industry, and households, from climate‐driven change components on four key water balance variables in the terrestrial hydrological system (evapotranspiration, runoff, soil moisture, storage change). We also analyzed emergent effect patterns in and across different parts of the world, facilitating exploration of spatial variability and regional patterns on multiple spatial scales, from pixel to global, including previously uninvestigated parts of the world. Our results show that human activities drive changes in all hydrological variables, with different magnitudes and directions depending on geographical location. The differences between model scenarios with and without human activities were largest in regions with the highest population densities. In such regions, which also have relatively large numbers of dams for irrigation, water largely tends to be removed from storage and go to feed increased runoff and evapotranspiration fluxes. Our analysis considers a more complete set of hydrological variables than previous studies and can guide further research and management planning for future hydrological and water availability trends, including in relatively data‐poor parts of the world. Plain Language Summary: The global population is growing, increasing demands for water use. Knowledge of how human activities affect water resources is available for some areas and water cycle components, but more data are needed for solid scientific understanding of climate and human‐driven effects on water resources in the past and present, and to underpin management approaches to future trends in hydrology and water availability. This study examined human activity effects on different components of the terrestrial water cycle, distinct from the effects of climate change. Results showed that human activities alter movements of water worldwide, with changes, magnitudes, and directions depending on world region. The greatest human‐driven changes emerged in regions with the highest population density, which also have relatively large numbers of dams providing water for agricultural use. Overall, the water changes in these regions tend to include water removal from storage going to feed increased evapotranspiration and/or runoff. Regions with such change trends will require solutions to overcome future negative impacts on society and ecosystems. This study showed how different water cycle components and land regions have been affected by changes in human activities, and findings can guide research and management planning for hydrological and water availability in future years. Key Points: Human activities affected all four hydrological variables studied (runoff, evapotranspiration, soil moisture, and storage change)Human‐driven hydrological effects emerged as considerable over the northern tropical to temperate latitudes, where most people liveHigher runoff was seen in areas with dams of various types, with additional hydrological effects depending on dam type [ABSTRACT FROM AUTHOR]