1. The roles of receptor tyrosine kinases and their ligands in the wound repair process.
- Author
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Müller AK, Meyer M, and Werner S
- Subjects
- Animals, Cell Differentiation, Cell Movement, Cell Proliferation, Gene Expression, Humans, Intercellular Signaling Peptides and Proteins genetics, Keratinocytes pathology, Keratinocytes physiology, Ligands, Receptor Protein-Tyrosine Kinases genetics, Receptors, Growth Factor genetics, Skin injuries, Skin metabolism, Skin pathology, Wounds, Penetrating metabolism, Wounds, Penetrating pathology, Intercellular Signaling Peptides and Proteins metabolism, Receptor Protein-Tyrosine Kinases metabolism, Receptors, Growth Factor metabolism, Wound Healing physiology
- Abstract
Cutaneous wound repair is a tightly regulated and dynamic process involving blood clotting, inflammation, formation of new tissue, and tissue remodeling. Gene expression profiling of mouse and human wounds as well as first proteomics studies have identified a large number of genes and proteins that are up- or downregulated by skin injury, and some of them have been functionally characterized in animal models of wound repair. Among the key regulators of wound repair are growth factors, which control migration, proliferation, differentiation and survival of cells at different stages of the healing process. This review summarizes the results of functional studies performed in mammals that have identified important roles of receptor tyrosine kinases and their ligands in wound repair., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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