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Excessive exudation from the wound site and the difficulty of determining the state of wound healing can make medical management more difficult and, in extreme cases, lead to wound deterioration. In this study, we fabricated a pH-sensitive colorimetric chronic wound dressing with self-pumping function using electrostatic spinning technology. It consisted of three layers: a polylactic acid-curcumin (PCPLLA) hydrophobic layer, a hydrolyzed polyacrylonitrile (HPAN) transfer layer, and a polyacrylonitrile-purple kale anthocyanin (PAN-PCA) hydrophilic layer. The results showed that the preparation of porous PLLA fiber membrane loaded with 0.2 % Cur was achieved by adjusting the spinning-related parameters, which could ensure that the composite dressing had sufficient anti-inflammatory, antibacterial and antioxidant properties. The HPAN membrane treated with alkali for 30 min had significantly enhanced liquid wetting ability, and the unidirectional transport of liquid could be achieved by simple combination with the 20 um PCPLLA fiber membrane. In addition, the 4 % loaded PCA showed more obvious color difference than the colorimetric membrane. In vivo and ex vivo experiments have demonstrated the potential of multifunctional dressings for the treatment of chronic wounds., Competing Interests: Declaration of competing interest The authors declare no competing interests., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Antibacterial hemostatic medical dressings have become feasible solutions in response to the challenging wound-healing process. In this study, a novel fiber-type medical dressing with excellent breathable, antibacterial, and hemostatic qualities was created using sodium alginate (SA), microcrystalline cellulose (MCC), polyvinyl alcohol (PVA), and Euphorbia humifusa Willd (EHW) based on microfluidic spinning technology, and the properties of the dressing were characterized. The orthogonal test demonstrates that PVA and MCC can enhance the mechanical properties of the fiber, which is a crucial requirement for fiber assembly to form the dressing. Moreover, the presence of EHW enhances the dressing's antibacterial and hemostatic qualities. The dressings have been proven to have potent antibacterial and hemostatic properties as well as the ability to considerably speed up wound healing and skin tissue regeneration in the in-vitro and in-vivo tests. In conclusion, this innovative fiber-type medical dressing containing SA, MCC, PVA, and EHW has enormous potential for managing wounds caused by bacteria. [ABSTRACT FROM AUTHOR]

[Display omitted] • Directional freeze-drying technology was applied to the preparation of dressings. • The double cross-linked effect enhanced the strength of the dressings. • Aligned channels allowed anisotropic dressings to absorb exudate effectively. • This dressing could significantly accelerate diabetic wound healing. Excessive biofluid around wounds can cause infection and prevent healing. In this study, an anisotropic quaternized chitosan (QC)/sodium alginate (AL)-based aerogel wound dressing was prepared via a directional freeze-drying technique inspired by the channel structure used for water transport in trees. The aligned channels provided the dressing with self-pumping ability, allowing it to rapidly and completely remove biofluids and absorb biofluids up to 1292.5 % of its own weight. To enhance the strength of the dressing, a double cross-linked network was constructed based on the QC-AL electrostatic attraction and AL-Ca2+ chelation interaction. The axial compressive strength of the double cross-linked dressing reached 207.3 kPa (ε = 50 %). In addition, the dressing exhibited strong conductive properties (conductivity = 13.0 S/m), antioxidant activities [reactive oxygen species (ROS) scavenging ability = 88.0 %], and hemostatic characteristics (blood coagulation index = 1.8 %). The dressing also exhibited powerful antibacterial performance, exhibiting over 98.0 % inhibition of E. coli and S. aureus. Experiments on diabetic mouse models revealed that the dressing considerably promoted wound healing. On day 3, the wound healing rate was 96.7 % faster in the QAC group than in the gauze group. Therefore, the developed dressing may have great potential for chronic wound care. [ABSTRACT FROM AUTHOR]

In the field of medical research, the development of safe and effective wound dressings is a continuous goal. Chitosan (CS) is highly sought after because of its unique biocompatibility, biodegradability, antibacterial, and healing-promoting properties. The CS molecule has a significant number of active amino and hydroxyl groups; thus, making substitutions and creating derivatives with varied biochemical properties are relatively straightforward processes. This review addresses the range of functions performed by CS and its derivatives in wound care, such as haemostasis, antibacterial, antioxidant, and wound healing. Furthermore, it summarises the various types of CS-based dressings, their performance features and applications. Finally, the future directions of CS-based dressings are proposed. [Display omitted] [ABSTRACT FROM AUTHOR]