1. Antinociceptive and wound healing effects of a commercial formulation of lidocaine, bupivacaine, adrenaline and cetrimide applied topically to superficial skin wounds in horses.
- Author
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Pratt S, Sole-Guitart A, de Klerk K, Evans E, Hume J, Palmieri C, Rainger J, and Goodwin W
- Subjects
- Animals, Horses, Male, Cetrimonium, Administration, Topical, Female, Analgesics therapeutic use, Analgesics administration & dosage, Treatment Outcome, Wounds and Injuries veterinary, Wounds and Injuries drug therapy, Anesthetics, Local administration & dosage, Anesthetics, Local therapeutic use, Anesthetics, Local pharmacology, Skin injuries, Skin drug effects, Drug Combinations, Lidocaine administration & dosage, Lidocaine therapeutic use, Lidocaine pharmacology, Wound Healing drug effects, Epinephrine administration & dosage, Bupivacaine administration & dosage
- Abstract
Background: Post-traumatic distal limb wounds cause discomfort and heal gradually by second intention. The topical application of Tri-Solfen (lidocaine hydrochloride, bupivacaine hydrochloride, adrenaline acid tartrate and cetrimide [LBAC]) produces effective postsurgical cutaneous analgesia in lambs, calves and piglets; however, its effect on wounds in horses is unknown., Methods: The antinociceptive effect, measured by mechanical threshold (MT), and the wound healing impacts of LBAC compared with saline were investigated on surgically created 20 × 20 mm distal limb wounds in 10 horses. Treatment was applied once daily for 7 days following wounding on day 0. Mechanical thresholds were measured after treatment on days 1, 2 and 3. Healing was observed for 25 days., Results: The topical application of LBAC immediately following wounding and its reapplication 24 hours later increased the average MT on the first post-traumatic day by 3 Newtons. However, no antinociceptive benefit was observed on days 2 or 3. Treatment with LBAC did not adversely affect wound healing when compared with saline., Limitations: Methodological differences preclude absolute MT comparisons between studies. The experimental design did not include a model of contaminated or naturally occurring wounds., Conclusion: LBAC may provide an early antinociceptive benefit when applied to uncontaminated surgically created wounds without compromising healing., (© 2024 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.)
- Published
- 2024
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