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Silver nanoparticles (AgNPs) have been emerged as significant wound healing agents because of their improved mechanical properties. However, the green synthesized silver nanoparticleshave reported significant wound healing action in Albino rats which was validated by the measurement of wound closure rate. Silver nanoparticles were efficiently synthesized using Euphorbia milii leaf extract. The UV-visible spectra recorded the effect of the reaction time on AgNPs synthesis and was indentified that the peak became shaper with an increase in time, which corresponds to increase in the number of nanoparticles formed from the reduction of silver ions present in the aqueous solution. X-ray diffraction technique and corresponding XRD patterns confirmed the biphasic nature of the biosynthesized silver nanoparticles. However, low magnification TEM images presented monodispersed AgNPs with their size ranging from 20 to 30 nm while SAED diffraction pattern disclosed their crystalline nature. Furthermore, the wound healing activity of AgNPs was examined through the excision wound model by measuring the rate of wound closure and Group II (treated with 10% Ointment base with biosynthesized AgNPs) revealed significant wound healing activity over Control group and Group I (treated with Standard Nitrofurazone ointment) in Albino rats., (Copyright © 2018 Elsevier B.V. All rights reserved.)