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Four triorganotin(IV) complexes, [(Ph3Sn)2L] (1), [(Et3Sn)2L]n (2), [(Me3Sn)2L] n (3), [(Me3Sn)3L(µ2-OH)] n (4) [H2L = 5-[(9-anthracenylmethylene)amino]-isophthalic acid], have been synthesized and characterized by elemental analysis, FT-IR, NMR spectroscopy and X-ray crystallography. DFT calculations were performed to calculate HOMO-LUMO energy gap and Mulliken charges of selected compounds. Single crystal diffraction reveals that complex 1 displays a dinuclear tin monomer. Complex 2 exhibits a 2D network structure with a tetranuclear 24-membered macrocycle. Similarly, complex 3 presents a 2D network structure containing two macrocycles, a dinuclear 16-membered macrocycle and a tetranuclear 32-membered macrocycle. Complex 4 presents a one-dimensional wireless chain that can form a 2D network structure through π − π interactions. The cytotoxic activities of the complexes 1–4 were investigated against HeLa, Hct-116, and A549 cancer cell lines and a normal cell line (LO2). Meanwhile, the anticancer mechanism of complex 1 was studied, and the results showed that complex 1 can increase intracellular reactive oxygen species, decline mitochondrial membrane potential (MMP), which may lead to apoptosis. [ABSTRACT FROM AUTHOR]

Five triorganotin (IV) complexes, [(Ph3Sn)2L] (1) [(Me3Sn)2L]n (2), [(n‐Bu3Sn)2L]n (3), [(n‐Bu 3Sn)2L(4,4′‐bpy)]n (4), [(n‐Bu3Sn)2L(bpe)]n (5) [H2L = 4,4′‐stilbenedicarboxylic acid, 4,4′‐bpy = 4,4′‐bipyridine, bpe = 4,4′‐vinylenedipyridine], were successfully prepared and structurally characterized by FT‐IR, elemental analysis, NMR spectroscopy, PXRD, and X‐ray crystallography. Complex 1 is a monomer containing two tin atoms, and 1D infinite chains can be formed between the monomers through CH···π interactions. Complexes 2 and 3 represent 2D network structures containing tetranuclear 38‐membered rings. Meanwhile, complexes 4 and 5 are 1D chain‐like structures and form the 2D network and 3D stereo structure via CH···O intermolecular interactions, respectively. The anticancer activities of the complexes were investigated against different cancer cells (A549, HeLa, and HepG‐2). Complexes 1 and 3–5 showed superior anticancer activity. Meanwhile, the anticancer mechanism of complex 1 was studied with the results that complex 1 can promote the production of excessive reactive oxygen species, induce mitochondrial membrane permeability depolarization, and release proapoptotic factors from mitochondria into the cytosol, followed by caspase‐3 activation, nuclei damage, and apoptosis. Excitingly, complex 1 also has good antimetastatic ability toward HepG‐2 cancer cells. [ABSTRACT FROM AUTHOR]

A series of new heteromultinuclear FeI/RuII clusters are described. The complexes (η6‐arene)RuFe2S2(CO)6 (arene = p‐cymene 1, C6Me62) and Fe2[μ‐S (Cp*Ru)(CO)2]2(CO)6 (Cp* = η5‐C5Me5) (3) were prepared by the reduction reactions of (μ‐S)2Fe2(CO)6 with 2 equiv of LiHBEt3, followed by treatment (μ‐SLi)2Fe2(CO)6 with ruthenium‐arene complexes Ru2(μ‐Cl)2Cl2(η6‐arene)2 or Cp*Ru (CO)2Cl in 22–33% yields. Further reactions of 1 and 2 with 1 equiv of triphenylphosphine in the presence of the decarbonylating agent Me3NO·2H2O, afforded the corresponding monophosphine‐substituted FeI/RuII complexes (η6‐arene)RuFe2S2(CO)5(Ph3P) (arene = p‐cymene 4, C6Me65) in 75% and 78% yields. While treatment of parent complex 1 or 2 with 1 equiv of diphosphine Ph2PCH2PPh2 (dppm) in xylene at reflux temperature resulted in the formation of the diphosphine‐bridged RuFe2S2(CO)9 derivate RuFe2S2(CO)7(dppm) (6). The possible pathway for the formation was proposed. Two isomers of novel macrocyclic complexes involve the (η6‐arene) Ru‐bridged quadruple‐butterfly Fe/S clusters [{μ‐S (CH2)3S‐μ}{(μ‐CS2)Fe2(CO)6}2]2[(η6‐arene)Ru]2 (arene = p‐cymene 7a and 7b, C6Me68a and 8b) were isolated by reactions of two μ‐CS2‐containing dianion [{μ‐S (CH2)3S‐μ}{(μ‐S=CS)Fe2(CO)6}2]2− with [Ru2(μ‐Cl)2Cl2(η6‐arene)2], in which the propylene groups are attached to two S atoms by ee and ea types of bonds respectively. All the new complexes 1–8 have been characterized by elemental analysis, spectroscopy, and particularly for 1–6, 7b and8a by X‐ray crystallography. In addition, the electrochemical properties of representative complexes 1–4 and 6 have been investigated. [ABSTRACT FROM AUTHOR]

A new series of fluorobenzenetelluronic triorganotin(iv) esters, namely (R3Sn)4H2L (H6L1 = [3-FC6H4TeO(OH)3]2, R = Me: 1, R = Ph: 2; H6L2 = [3,4-F2C6H3TeO(OH)3]2, R = Me: 3, R = Ph: 4; H6L3 = [3,4,5-F3C6H2TeO(OH)3]2, R = Me: 5, R = Ph: 6), have been synthesized by the reaction of deprotonated fluorobenzenetelluronic acid ligands with the corresponding R3SnCl (R = Me, Ph). All the complexes have been characterized by means of elemental analysis, FT-IR, NMR (1H, 13C, 119Sn) spectroscopy and X-ray crystallography. Structural analyses of the complexes reveal that they are isostructural and display an almost planar four-membered Te2(μ2-O)2 core in the center. Each Te atom adopts a distorted octahedral geometry and each Sn atom adopts a distorted tetrahedral geometry. Complexes 1, 3, 5, and 6 form one-dimensional supramolecular structures, while 2 and 4 form two-dimensional supramolecular structures by intermolecular C–H…F or C–H…O interactions. Preliminary in vitro cytostatic studies show that these fluorobenzenetelluronic triorganotin esters exhibit effective cytostatic activity against a human cervical adenocarcinoma cell line (HeLa) and a human hepatocellular carcinoma cell line (HepG-2). For further discerning the apoptotic properties of cytostatic activity, the level of apoptosis was determined by flow cytometry (FACS assay). The DNA-binding properties of these complexes with calf thymus DNA (CT-DNA) and protein-binding properties with BSA were investigated by means of fluorescence titration. The results indicate that all the complexes could quench the intrinsic fluorescence of BSA in a static way. [ABSTRACT FROM AUTHOR]

Four newμ2-oxo-bridged dinuclear aryltelluronic triorganotin esters [ArTe(μ-O)(OH)(OSnR3)2]2(Ar = n-propyl-Ph,R = Me:1,R = Ph:2; Ar = i-propyl-Ph,R = Me:3,R = Ph:4) were synthesized by reaction ofμ2-oxo-bridged dinuclear aryltelluronic acids and the corresponding R3SnCl (R = Me, Ph) with potassium hydroxide in methanol. The complexes were characterized by X-ray crystallography, elemental analysis, FT-IR, and NMR (1H,13C,119Sn) spectroscopy. The structural analysis indicates that these complexes are isostructural and crystallized as Sn4Te2molecules, in which the asymmetric four-membered Te2(μ2-O)2units are situated in the center. The geometry of tellurium is described as a distorted octahedron and each tin is described as a distorted tetrahedron. Complex2has a 2-D network structure connected by intermolecular C–H⋯π interactions. Complexes1–4were tested forin vitrocytotoxicity against human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). [ABSTRACT FROM AUTHOR]

Abstract: Six new tin complexes of the formulae [(Ph3Sn)2(PhSn)10(Sn)2(μ2-O)8(μ3-O)18(C7HCl3O3)2] (1), {[(n-Bu)3Sn]2(C7HCl3O3)} n (2), [(Me3Sn)2(C7HCl3O3)] n (3), [(Ph2Sn)(C7HCl3O3)2] (4), [(n-Bu)2Sn(C7HCl3O3)2] (5) and [(Me2Sn)4(C7HCl3O3)2(μ3-O)2(CH3O)2] (6) have been obtained from 3,5,6-trichlorosalicylic acid and an organotin chloride or organotin oxide. All the complexes were characterized by elemental analysis, FT-IR and NMR (1H, 13C and 119Sn) spectroscopy; complexes 1, 3 and 6 were further characterized X-ray crystallography diffraction analyses. The structural analyses reveal that complex 1 has a novel cage structure, which contains two triphenyltin nuclei, 10 monophenyltin nuclei and two inorganic tin nuclei; complex 3 has an infinite chain structure and complex 6 displays a typical ladder structure. [Copyright &y& Elsevier]

Two new macrocyclic complexes, [ML](ClO4)2·4,4′-bpy [M = Cu (1) and Ni (2), L = 1,3,6,9,11,14-hexaazatricyclo [12.2.1.16,9]octadecane, 4,4′-bpy = 4,4′-bipyridine], have been synthesized and structurally characterized by X-ray crystallography analyses. Complex 1 crystallizes in the triclinic crystalline system of space group P–1, while complex 2 crystallizes in the monoclinic crystalline system of space group P21/n. In the both complexes, M(II) [M = Cu (1) and Ni (2)] centers are located in a distorted square plane environment. The weakly interactions raised the structure unit to a 3D network. [ABSTRACT FROM PUBLISHER]

A series of organotin(IV) carboxylates complexes; namely, [(Me 2Sn) 4O 2(RCOO) 4] ( R = C 12H 151, C 9H 112, C 8H 8ClO 3, C 7H 94) and [Me 3(RCOO)] n ( R = C 12H 155, C 9H 116, C 8H 8ClO 7, C 7H 98) have been synthesized. All complexes were characterized by elemental analysis, FT-IR, and NMR ( 1H, 13C and 119Sn) spectroscopy. Among them, the structures of complexes 1– 3 and 5– 8 were also determined by X-ray crystallography. The structural analysis showed that complexes 1– 3 are the same tetranuclear monomer, and complexes 5– 8 are the same 1D zigzag chain coordination polymer. Furthermore, each complex 1, 2 and 3, can form a supramolecular chain through weak intermolecular interactions. [ABSTRACT FROM AUTHOR]

A mononuclear fragment [Cu(L)Cl]ClO ( 1) and a cyano-bridged Cu-Ni binuclear complex [CuL][Ni(CN)]·0.25HO ( 2) (L = 1,3,6,8,11,14-hexaazatricyclo[12.2.1.18,11]-octadecane), have been prepared and characterized. X-ray single crystal analyses indicate that the both complexes crystallize in the monoclinic crystalline system. The complex of 1 in P1 n1 space group with unit cell constants a = 6.1176(6) Å, b = 11.9147(10) Å, c = 12.2041(12) Å, β = 98.816(5)° and 2 in the P2/ n space group with unit cell constants a = 8.1419(13) Å, b = 14.695(2) Å, c = 16.863(3) Å, β = 98.375(2)° have been revealed. The complex 2 assumes a binuclear structure in which the nickel(II) ion is in a square planar environment and the copper(II) is in a square-prism geometry environment. Graphical Abstract: A novel Cu-Ni bimetallic assembly constructed from Cu macrocyclic ligand and [Ni(CN)] anion.[Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

Two different polyoxozirconium oxide clusters tri- and tetranuclear half-zirconocene complexes assisted by 2,3,4,5-tetrafluorobenzoic acid and 3,4,5,6-tetrafluorophthalic acid have been synthesized and characterized by elemental analysis, FT-IR, NMR (1H, 19F, and 13C) spectroscopy, and X-ray crystallography. The structure analyses reveal that 1 is trinuclear with a µ3-oxygen bridge, central to a Zr-O backbone; 2 is a tetranuclear complex with four Zr's tetrahedrally arranged around a µ4-oxygen. [ABSTRACT FROM AUTHOR]

Abstract: A series of drum structures of organotin complexes with various carboxylic acids have been solvothermally synthesized and characterized by elemental analysis, FT-IR, NMR (1H, 13C and 119Sn) spectra and X-ray crystallography. The molecular structure analyses reveal that all of the complexes have endo drum structures. Furthermore, each of the drum structures has a hole, in which atoms of a given radius could be held. [Copyright &y& Elsevier]

Abstract: A series of organotin(IV) complexes with 5-phenyl-1,3,4-oxadiazole-2-thiol of the type R3Sn[S(C8H5N2O)] (R=Me 1, n-Bu 2, PhCH2 3, Cy 4, Ph 5) have been synthesized. All the complexes 1–5 have been characterized by elemental, IR, 1H NMR, 13C NMR analyses and X-ray crystallography. Among them, the central tin atoms of complexes 1–5 are all five-coordinated with distorted trigonal bipyramidal geometry. Interestingly, complexes 1–4 exhibit 1D polymeric chains through Sn and N intermolecular interactions. [Copyright &y& Elsevier]

Abstract: Seven new organotin (IV) carboxylates have been synthesized by the reactions of 6-chloro-3-pyridineacetic acid with triorganotin chloride and diorganotin dichloride. All the complexes were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 119Sn NMR and X-ray crystallography. The structural analyses show that all the complexes present various structures, including monomer, drum, 1D polymers and ladders. It is worth noting that complex 1 is a novel 1D spring-like helical chain containing guest solvent molecules. [Copyright &y& Elsevier]

Graphical abstract In this work, we found the reaction of (μ -PhCH 2 Se) 2 Fe 2 (CO) 6 (A) with the bisphosphine ligands can get different types of carbonyl substituted model complexes, depending on reaction conditions and the structure of the phosphine ligands. It is interesting to find that C Se bond homolysis is detected in the reaction of A with dppn in refluxing xylene. Abstract The reactions of (μ -PhCH 2 Se) 2 Fe 2 (CO) 6 (A) with the bisphosphine ligands [L = Ph 2 PCH 2 PPh 2 (dppm), cis -Ph 2 PC 2 H 2 PPh 2 (dppv), and (Ph 2 P) 2 N(n -Pr) (dppn)] under various experimental conditions have been studied. Reaction of A with dppm and Me 3 NO in MeCN at room temperature to give (μ -PhCH 2 Se) 2 Fe 2 (CO) 5 (k -dppm) (1), where only one phosphorus atom of dppm is coordinated in a monodentate fashion to Fe 2 Se 2 unit. Reaction of A with dppv and Me 3 NO in toluene/MeCN at room temperature to give (μ -PhCH 2 Se) 2 Fe 2 (CO) 4 (k2 -dppv) (2), where two phosphorus atoms of dppv are chelated to a single iron. While the (μ -PhCH 2 Se) 2 Fe 2 (CO) 4 (μ -dppm) (3) and (μ -PhCH 2 Se) 2 Fe 2 (CO) 4 (μ -dppn) (4) can be prepared by treatment of A with 1 equiv of dppm or dppn in refluxing xylene, where the phosphine acts as a bidentate ligand. Interestingly, the C Se bond homolysis is detected in the reaction of A with dppn, and unexpected dppn-bridged complex (μ -Se) 2 Fe 2 (CO) 4 (μ -dppn) (5) is isolated. All the complexes were characterized by elemental analysis, FT-IR, NMR spectroscopy, as well as by X-ray diffraction analyses. [ABSTRACT FROM AUTHOR]

Graphical abstract Six new organotin(IV) complexes have been designed and synthesized from the reactions of 4-carboxybenzenesulfonamide with the corresponding triorganotin(IV) chloride or diorganotin(IV) oxide. Meanwhile, complexes 1–5 were evaluated for their in vitro cytostatic activity against HeLa cell lines and HepG-2 cell lines. Abstract A new series of 4-carboxybenzenesulfonamide organotin(IV) complexes, [Me 3 Sn(O 2 CC 6 H 4 -SO 2 NH 2 -4)] (1), [ n -Bu 3 Sn(O 2 CC 6 H 4 -SO 2 NH 2 -4)] (2), [Ph 3 Sn(O 2 CC 6 H 4 -SO 2 NH 2 -4)] (3), [(Me 2 Sn) 4 (μ 3 -O) 2 (μ 2 -OCH 3) 2 (O 2 CC 6 H 4 -SO 2 NH 2 -4) 2 ] (4), [(n -Bu 2 Sn) 4 (μ 3 -O) 2 (μ 2 -OCH 3) 2 (O 2 CC 6 H 4 -SO 2 NH 2 -4) 2 ] (5), [(n -Oct 2 Sn) 4 (μ 3 -O) 2 (μ 2 -OCH 3) 2 (O 2 CC 6 H 4 -SO 2 NH 2 -4) 2 ] (6), have been designed and synthesized from the reactions of 4-carboxybenzenesulfonamide with the corresponding triorganotin(IV) chloride or diorganotin(IV) oxide. The six complexes were characterized by elemental analysis, FT-IR, NMR (1H, 13C and 119Sn) spectroscopy, as well as by single crystal X-ray diffraction analysis. X-ray diffraction discloses that complexes 1–3 represent mononuclear tin(IV) monomer, and complexes 4–6 adopt tetranuclear tin(IV) ladder-like structure containing two deprotonated ligands linked by three alternate Sn 2 O 2 four-membered rings. Analysis of the non-covalent intermolecular contacts in all complexes reveals the existence of the N H⋯O C, N H⋯O S and Sn⋯O interactions, which play significant function in the supramolecular construction. Furthermore, complexes 1–5 were evaluated for their in vitro cytostatic activity against human cervical carcinoma cell lines (HeLa) and human hepatocellular carcinoma cell lines (HepG-2). The pilot study has confirmed that some of these novel organotin(IV) complexes exhibited high in vitro cytostatic activity. [ABSTRACT FROM AUTHOR]

Two seven-coordinate organotin complexes, namely, [(Me 2 Sn) ( μ -L) (4,4′-bipy) 0.5 (CH 3 OH) (DMF)] n ( 1 ) and [(Me 2 Sn) ( μ -L) (1,10-phen)] n ( 2 ) (H 2 L = 6,6′-dithionicotinic acid, 4,4′-bipy = 4,4′-bipyridine and 1,10-phen = 1,10-phenanthroline), were synthesized in a 1:1:1 M ratio reaction of Me 2 SnCl 2 , 6,6′-dithionicotinic acid and different N-donor ligands. Both complexes have been characterized by elemental analysis, IR, PXRD, TGA, and X-ray crystallography. The structural analysis reveals that complex 1 contains hexanuclear 78-membered macrocycles which further construct a 2D wavelike polymeric structure, while complex 2 displays 1D right-handed helical chain. Complex 1 is further linked into a 3D supramolecular architecture through the intermolecular C13-H13B⋯O2 interactions, and complex 2 is connected into a 2D supramolecular structure by the intermolecular C14-H14⋯N3 interactions. In such a system, both the μ -L 2 − anion ligand and nitrogen-containing ligands act as bipodal linkers facilitating the formation of metal-organic frameworks. [ABSTRACT FROM AUTHOR]

Three novel cobalt(II) coordination complexes constructed by 3,4,5-trifluorobenzeneseleninic acid (L) and different N-donor ligands, namely, [Co(4,4′-bpy)(L) 2 ] n ( 1 ), [Co(2,2′-bpy)(L) 2 ] n ( 2 ), [Co 2 (en) 4 (L) 2 (NO 3 ) 4 ]·(CH 3 CN) 2 ( 3 ). (4,4′-bpy = 4,4′-bipyridine, 2,2′-bpy = 2,2′-bipyridine, and en = ethylenediamine) have been designed, synthesized and characterized by IR spectroscopy, elemental analysis, single-crystal X-ray diffraction analyses. In the three complexes above, the 3,4,5-trifluorobenzeneseleninic acid ligand adopt anti–anti bridging coordination mode and all the cobalt ions show distorted octahedral configurations. Complex 1 displays a 2D layer structure, which is further connected by π⋯π interactions to give rise to a 3D supramolecular structure. The structure of complex 2 exhibits 1D tube-like double chain structure and the neighboring chains are further linked by hydrogen-bonds C–H⋯F and π⋯π interactions to form a 3D supramolecular structure. However, complex 3 is a monomer which can be connected into a 2D supramolecular layer through the intermolecular C–H⋯O hydrogen-bonds interaction. In addition, the magnetic properties of complexes 1 and 2 are characterized. [ABSTRACT FROM AUTHOR]

Four new p -aminobenzenesulfonate organotin complexes, [( n -Bu 3 Sn)(O 3 SC 6 H 3 -NH 2 -4)] n ( 1 ), [( n -Bu 2 Sn) 4 (O) 2 (OH) 2 (O 3 SC 6 H 4 -NH 2 -4) 2 ] ( 2 ), [(Me 2 Sn) 4 (O) 2 (OH) 2 (O 3 SC 6 H 4 -NH 2 -4) 2 ] ( 3 ) and [{( n -BuSn) 12 O 14 (OH) 6 }(O 3 SC 6 H 4 -NH 2 -4) 2 ·3C 4 H 8 O 2 ] ( 4 ·diox), were synthesized by reaction of p -aminobenzenesulfonic acid with tributyltin oxide, dibutyltin oxide, dimethyltin oxide and monobutyltin oxide, respectively. These complexes were characterized by elemental analysis, FT-IR, NMR ( 1 H, 13 C, 119 Sn) spectroscopy as well as single-crystal X-ray diffraction. The crystal structure of complex 1 reveals that it is a 1D zig-zag chain structure and further interlinked into a 2D network by intermolecular interaction (N-H⋯O). The structure analysis indicates that complexes 2 and 3 are the ladder-like structure including three alternate Sn 2 O 2 rings, and further result in the formation of a 3D supramolecular architecture for 2 and a 2D supramolecular network for 3 by extensive hydrogen-bonding interactions (O-H⋯O, N-H⋯O). Complex 4 exhibits a dodecanuclear organooxotin cages, which are connected into a hydrogen-bonded 2D structure. Furthermore, complexes 1 - 4 were evaluated for their in vitro cytostatic activity against the human lung cancer cells (A549) and the human hepatocellular carcinoma cells (HepG-2). The preliminary screen shows that organotin derivatives with increasing number n -butyl group exhibitsignificantly higher cytostatic activity, and much higher than methyl group. [ABSTRACT FROM AUTHOR]

Reactions of R 2 SnCl 2 (R = Me) or R 3 SnCl (R = Me, Ph) with the respective dinuclear aryltellurinic acid (H 6 L 1 = [3,4-Me 2 C 6 H 3 TeO(OH) 3 ] 2 and H 6 L 2 = [3,5-Me 2 C 6 H 3 TeO(OH) 3 ] 2 ) afforded two types of aryltelluronic organotin esters: [R 2 Sn(CH 3 OH)(R 2 SnCl)] 2 L (L 1 = [3,4-Me 2 C 6 H 3 TeO 4 ] 2 , R = Me: 1 ; L 2 = [3,5-Me 2 C 6 H 3 TeO 4 ] 2 , R = Me: 4 ) and [(R 3 Sn) 2 H] 2 L (L 1 = [3,4-Me 2 C 6 H 3 TeO 4 ] 2 , R = Me: 2 , R = Ph: 3 ; L 2 = [3,5-Me 2 C 6 H 3 TeO 4 ] 2 , R = Me: 5 , R = Ph: 6 ). All the complexes were characterized by means of elemental analysis, FT-IR, and NMR ( 1 H, 13 C, 119 Sn) spectroscopy as well as X-ray crystallography. Single crystal X-ray diffraction shows that they are isostructural and crystallized as Sn 4 Te 2 molecules, in which an almost planar four-membered Te 2 ( μ 2 -O) 2 units are situated in the center. Moreover, what is novel about 1 and 4 is that there exists a centrosymmetric 8-member macrocyle containing Sn 2 Te 2 O 4 dipping perpendiculared to the Te 2 O 2 ring. The geometry of the tellurium atom is described as a distorted octahedron, and tin atoms are best described as distorted tetrahedron and distorted trigonal bipyramid. Through intermolecular weak interactions, both complexes 1 and 4 have two dimensional network structures and complex 2 shows one dimensional infinite polymeric chain structure. Furthermore, in vitro cytotoxicities of complexes 1 – 6 were also evaluated, using human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). [ABSTRACT FROM AUTHOR]

• Four new triorganotin(IV) esters based on 3,5-bifluorobenzenetelluronic acid. • Complexes 1 – 2 display dimeric structure, while 3 – 4 display monomeric structure. • In vitro cytostatic activity and BSA-binding properties of complexes 1 – 4 were tested. Four novel 3,5-bifluorobenzenetelluronic triorganotin(IV) esters, namely (3,5-F 2 C 6 H 3 TeOH) 2 (μ-O) 2 (OSnR 3) 4 (R = Me: 1 , R = Ph: 2) and (3,5-F 2 C 6 H 3 TeOH)(OSnR 3) 4 (R = Me: 3 , R = Ph: 4) have been synthesized and characterized by the reaction of deprotonated 3,5-bifluorobenzenetelluronic acid ligand and corresponding R 3 SnCl (R = Me, Ph). All the complexes have been characterized by means of elemental analysis, FT-IR, NMR (1H, 13C, 119Sn) spectroscopy, and X-ray crystallography. Structural analyses of these complexes reveal that complexes 1 and 2 exhibit centrosymmetric dimeric structure with an almost planar four-membered Te 2 (μ 2 -O) 2 core in the center, while 3 and 4 form monomeric structure with a single Te center. The Te atoms adopt octahedral geometry in all the complexes. Complexes 1 – 4 could form 2D or 3D supramolecular structures through intermolecular C-H···F or C-H···O interactions. Preliminary in vitro cytostatic studies show that complexes 1 – 4 exhibit effective cytostatic activity against human cervix adenocarcinoma cell lines (HeLa) and human hepatocellular carcinoma cell lines (HepG-2). For further assessing apoptosis properties of complex 2 , the levels of apoptosis were examined. The BSA-binding properties were investigated by means of fluorescence titration. The results indicate that complexes 1 – 4 could quench the intrinsic fluorescence of BSA. [ABSTRACT FROM AUTHOR]