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Synthetic approaches to three cyclic 2,4,5,6-tetrakis(hydroxymethyl)pyridin-3-ol acetonides were developed. Among seven possible mono- and diketals, six-membered cyclic ketal incorporating the hydroxymethyl group in the 4-position turned out to be the most thermodynamically favorable. The experimental data were consistent with the results of quantum-chemical calculations of the Gibbs energies of formation of different acetonides. The structure of the isolated compounds was studied by X-ray diffraction. [ABSTRACT FROM AUTHOR]

The article presents a study which investigates the development of the new synthesis method of pyridoxine IV hydroxymethylated. It states that the study has determined three stages which include the acetonide protection of hydroxymethyl groups, the hydroxymethylation of the seven-membered cyclic pyridoxine, and the removal of the protection in the acid medium. The article also features the research on the x-ray diffraction (XRD) analysis of crystal of compounds.