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Two new xanthone glycosides ( 1 - 2 ), together with seven known analogues ( 3 - 9 ), were isolated from whole herb of Swertia punicea . The structures of these metabolites were established on the basis of detailed spectroscopic analysis and comparison with data reported in the literature. In an in vitro test, all isolates were evaluated for their anti-inflammatory activity. The results revealed that all of them showed significant anti-inflammatory activity with IC 50 values ranging from 1.237 to 3.319 mM. Compounds 3 , 4 , and 5 (IC 50 values in the range 1.237-1.987 mM) displayed more potent anti-inflammatory activity than the positive control, indomethacin (IC 50 value of 2.004 mM).

Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively.

Two new xanthones, atroxanthones A and B ( 1 and 2), together with four known xanthones ( 3-6), were isolated from the whole herb of Swertia atroviolacea. The structures of the metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1 and 2 were evaluated for their anti-5α-reductase activity. The results revealed that 1 and 2 had weak activity with reductase inhibitions of 52.3 ± 2.5% and 42.9 ± 2.8%, respectively. [ABSTRACT FROM AUTHOR]

Three new xanthones (1–3), together with five known ones (4–8), were isolated from whole herb ofSwertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively. [ABSTRACT FROM PUBLISHER]