1. [Progress in research of the structural optimization of natural product-like Garcinia caged xanthones].
- Author
-
Wang YY, Zhang XJ, Yang YR, Sun HP, and You QD
- Subjects
- Cell Line, Tumor, Cell Proliferation drug effects, Drug Screening Assays, Antitumor, Humans, Molecular Structure, Structure-Activity Relationship, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Biological Products chemical synthesis, Biological Products chemistry, Biological Products isolation & purification, Biological Products pharmacology, Garcinia chemistry, Xanthones chemical synthesis, Xanthones chemistry, Xanthones isolation & purification, Xanthones pharmacology
- Abstract
Designing of natural product-like compounds using natural products as template structures is an important strategy for the discovery of new drugs. Gambogic acid (GA), which is a Garcinia natural product with a unique caged xanthone scaffold, inhibits potent antitumor activity both in vitro and in vivo. This review summarized the researches on the identification of the antitumor pharmacophore of GA, and the design, structural optimization and structure-activity relationship (SAR) of natural product-like caged xanthones based on it.
- Published
- 2014