Search

Your search keyword '"Juan Gutiérrez-Aroca"' showing total 3 results
Start Over Author "Juan Gutiérrez-Aroca" Topic young adult
3 results on '"Juan Gutiérrez-Aroca"'

1. Pretransplant interferon-γ secretion by CMV-specific CD8+ T cells informs the risk of CMV replication after transplantation

Author

J. Redel, Sara Cantisán, L. Bueno, Juan Gutiérrez-Aroca, Julián Torre-Cisneros, Rosario Lara, Antonio Rivero, Alberto Rodríguez-Benot, Rafael Solana, Marcelino González-Padilla, and Miguel Montejo

Subjects
Adult, Graft Rejection, Male, Congenital cytomegalovirus infection, Cytomegalovirus, CD8-Positive T-Lymphocytes, Antiviral Agents, Virus, Interferon-gamma, Young Adult, Interferon, Risk Factors, medicine, Immunology and Allergy, Cytotoxic T cell, Humans, Pharmacology (medical), Longitudinal Studies, Prospective cohort study, Aged, Transplantation, Lung, business.industry, Middle Aged, medicine.disease, Prognosis, Kidney Transplantation, medicine.anatomical_structure, Immunology, Cytomegalovirus Infections, Female, business, CD8, Biomarkers, medicine.drug, Lung Transplantation
Abstract

In this prospective study we analyzed pretransplant interferon-γ secretion by cytomegalovirus (CMV)-specific CD8+ T cells to assess its possible utility in determining the risk of CMV replication after solid organ transplantation. A total of 113 lung and kidney transplant patients were enrolled in the study but only 55 were evaluable. All CMV-seronegative recipients were pretransplant "nonreactive" (IFNγ

Published
2012

2. Comparison of Two Molecular Methods for Rapid Diagnosis of Extrapulmonary Tuberculosis

Author

Manuel Causse, Pilar Ruiz, Juan Gutiérrez-Aroca, and Casal M

Subjects
Adult, Male, Microbiology (medical), Tuberculosis, Adolescent, Cobas taqman, Pcr assay, Sensitivity and Specificity, Mycobacterium tuberculosis, Young Adult, Tuberculosis diagnosis, M. tuberculosis, Humans, Medicine, Child, Aged, Aged, 80 and over, Bacteriological Techniques, biology, business.industry, Extrapulmonary tuberculosis, Mycobacteriology and Aerobic Actinomycetes, Middle Aged, biology.organism_classification, medicine.disease, bacterial infections and mycoses, Virology, False-positive result, Real-time polymerase chain reaction, Molecular Diagnostic Techniques, Child, Preschool, Immunology, Female, business, Real-time PCR
Abstract

Application of real-time PCR for the detection of Mycobacterium tuberculosis enables results to be obtained in about 2 h. A total of 340 nonrespiratory samples were processed using two real-time PCR assay kits: Xpert MTB/RIF and Cobas TaqMan MTB. The sensitivity and specificity of the Xpert assay were 95% and 100%, respectively, compared to 78% and 98% for the Cobas assay.

Published
2011

3. CD45RA expression on HCMV-specific effector memory CD8+ T cells is associated with the duration and intensity of HCMV replication after transplantation

Author

Inmaculada Gayoso, Jose Manuel Vaquero, Antonio Rivero, Julián Torre-Cisneros, Rosario Lara, Juan Gutiérrez-Aroca, Miguel Montejo, Rafael Solana, Sara Cantisán, and Alberto Rodríguez-Benot

Subjects
Human cytomegalovirus, Adult, Male, Time Factors, Adolescent, viruses, Immunology, chemical and pharmacologic phenomena, Biology, CD8-Positive T-Lymphocytes, Antibodies, Viral, Virus Replication, Young Adult, Immune system, immune system diseases, T-Lymphocyte Subsets, medicine, Immunology and Allergy, Cytotoxic T cell, Humans, Lymphocyte Count, Aged, Transplantation, Effector, virus diseases, hemic and immune systems, T lymphocyte, Middle Aged, Viral Load, medicine.disease, Kidney Transplantation, Tissue Donors, Cross-Sectional Studies, Viral replication, Cytomegalovirus Infections, Multivariate Analysis, Leukocyte Common Antigens, Female, CD8, Lung Transplantation
Abstract

In this cross-sectional study on 42 solid organ transplant recipients, the association of kinetics of human cytomegalovirus (HCMV) replication and EMRA HCMV-specific CD8+ T cells was investigated. Correlation was observed between the duration of HCMV replication after transplantation and CD45RA+CD27− (r = 0.609; p = 0.004), CD45RA+ CD28− (r = 0.579; p = 0.008) or CD45RA+CCR7− (r = 0.488; p = 0.029) HCMV-specific CD8+ T cells percentages. In the multivariate regression analyses, CD45RA+CD27−, CD45RA+CD28− or CD45RA+CCR7− HCMV-specific CD8+ T cells percentages increased 5.58% (p = 0.001), 5.35% (p = 0.001) or 4.49% (p = 0.012), respectively, with every 10-day increase in the duration of HCMV replication. Moreover, CD45RA+CD27− or CD45RA+CD28− frequencies increased 4.16% (p = 0.024) or 3.58% (p = 0.049), respectively, with every unity increase in log10 genomes/mL. These observations support the major association between the frequency of EMRA HCMV-specific CD8+ T cells and the duration of post-transplant HCMV replication episodes in solid organ transplantation recipients.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results