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Your search keyword '"Immunopathology -- Research"' showing total 5 results
Start Over Descriptor "Immunopathology -- Research" Topic zoology and wildlife conservation
5 results on '"Immunopathology -- Research"'

1. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Author

Cebula, Anna, Seweryn, Michal, Rempala, Grzegorz A., Pabla, Simarjot Singh, McIndoe, Richard A., Denning, Timothy L., Bry, Lynn, Kraj, Piotr, Kisielow, Pawel, and Ignatowicz, Leszek

Subjects
T cells -- Research, Microbiota (Symbiotic organisms), Immunopathology -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal microbiota involve [CD4.sup.+] [Foxp3.sup.+] regulatory T ([T.sub.reg]) cells (1,2) generated in the thymus or extrathymically by induction of naive [CD4.sup.+] [Foxp3.sup.-] [...]

Published
2013
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2. Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

Author

Keestra, A. Marijke, Winter, Maria G., Auburger, Josef J., Frassle, Simon P., Xavier, Mariana N., Winter, Sebastian E., Kim, Anita, Poon, Victor, Ravesloot, Marietta M., Waldenmaier, Julian F.T., Tsolis, Renee M., Eigenheer, Richard A., and Baumler, Andreas J.

Subjects
Transfection, Immunopathology -- Research, Nucleotides -- Properties, Guanosine triphosphatase -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Our innate immune system distinguishes microbes from self by detecting conserved pathogen-associated molecular patterns (1). However, these are produced by all microbes, regardless of their pathogenic potential. To distinguish virulent [...]

Published
2013

3. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

Author

Amiri, Payman, Locksley, Richard M., Parslow, Tristram G., Sadick, Michael, Rector, Ernest, Ritter, Dianne, and McKerrow, James H.

Subjects
Tumor necrosis factor -- Physiological aspects, Granuloma -- Research, Schistosomiasis -- Physiological aspects, Immunological deficiency syndromes -- Research, Immunopathology -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Published
1992

4. In the beginning: immune cells cross the inflamed blood-brain barrier. But it's unclear how brain inflammation begins before immune-cell entry. Studies of a model of multiple sclerosis start to solve this 'chicken and egg' conundrum

Author

Ransohoff, Richard M.

Subjects
Inflammation -- Diagnosis -- Research, Multiple sclerosis -- Diagnosis -- Research, Brain diseases -- Diagnosis -- Research, Immunopathology -- Research, Leukocytes -- Properties -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Multiple sclerosis, a disorder of the central nervous system (CNS), is characterized by damage to myelin, the insulating membrane that surrounds nerve fibres. The lesions found in multiple sclerosis are [...]

Published
2009

5. Parasitizing the cytokine system

Author

Sher, Alan

Subjects
Schistosomiasis -- Physiological aspects, Cytokines -- Physiological aspects, Tumor necrosis factor -- Physiological aspects, Granuloma -- Physiological aspects, Immunopathology -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Tumor necrosis factor (TNF), a cytokine, can produce egg granulomas and the schistosomes, the parasitic worms that cause schistosomiasis, employ host TNF alpha to stimulate reproduction. Researcher P. Amiri and colleagues found that the schistosome pathogens are able to use TNF when T and B lymphocytes, which form part of the body's immune system, are not present. These findings may lead the way to more research on the co-evolution of parasites and host cytokine responses.

Published
1992

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