1. Multiple origins of foot-and-mouth disease virus serotype Asia 1 outbreaks, 2003-2007.
- Author
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Valarcher JF, Knowles NJ, Zakharov V, Scherbakov A, Zhang Z, Shang YJ, Liu ZX, Liu XT, Sanyal A, Hemadri D, Tosh C, Rasool TJ, Pattnaik B, Schumann KR, Beckham TR, Linchongsubongkoch W, Ferris NP, Roeder PL, and Paton DJ
- Subjects
- Afghanistan epidemiology, Animals, Asia epidemiology, China epidemiology, DNA, Viral genetics, Disease Outbreaks, Foot-and-Mouth Disease Virus classification, Geography, Humans, India epidemiology, Nepal epidemiology, Pakistan epidemiology, Phylogeny, RNA, Viral genetics, Reverse Transcriptase Polymerase Chain Reaction, Serotyping, Foot-and-Mouth Disease epidemiology, Foot-and-Mouth Disease Virus genetics
- Abstract
We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.
- Published
- 2009