1. Detecting recent positive selection in the human genome from haplotype structure.
- Author
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Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, and Lander ES
- Subjects
- Africa, Alleles, Animals, CD40 Ligand genetics, Computer Simulation, Evolution, Molecular, Gene Pool, Genetic Variation genetics, Glucosephosphate Dehydrogenase genetics, Homozygote, Humans, Malaria enzymology, Malaria parasitology, Male, Mutation genetics, Plasmodium falciparum physiology, Polymorphism, Single Nucleotide genetics, Time Factors, Genetic Predisposition to Disease genetics, Genome, Human, Haplotypes genetics, Malaria genetics, Selection, Genetic
- Abstract
The ability to detect recent natural selection in the human population would have profound implications for the study of human history and for medicine. Here, we introduce a framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations. We first identify haplotypes at a locus of interest (core haplotypes). We then assess the age of each core haplotype by the decay of its association to alleles at various distances from the locus, as measured by extended haplotype homozygosity (EHH). Core haplotypes that have unusually high EHH and a high population frequency indicate the presence of a mutation that rose to prominence in the human gene pool faster than expected under neutral evolution. We applied this approach to investigate selection at two genes carrying common variants implicated in resistance to malaria: G6PD and CD40 ligand. At both loci, the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection. More generally, the method could be used to scan the entire genome for evidence of recent positive selection.
- Published
- 2002
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