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Background: Children bear a substantial proportion of the enteric fever disease burden in endemic areas. Controversy persists regarding which age groups are most affected, leading to uncertainty about optimal intervention strategies. We performed a systematic review and meta-analysis of studies in Asia and Africa to compare the relative proportion of children with enteric fever in the age groups. Materials and methods: This prospective research was conducted at Tertiary Care Teaching Hospital over a Period of 1 year. A total of 90 pediatric cases of EF were included in this study who were either culture positive or had significantly raised Widal test titer for Salmonella with suggestive clinical features. A total of 200 children aged one to 15 years who were either blood culture positive for the Fastidious Antibiotic Neutralization (FAN) or had significant Widal test titer (at least four-fold rises or 1:160 dilutions of both O and H antibodies) were included in the study. Those who had enteric fever with comorbidities (malignancy, nephrotic syndrome, chronic kidney disease, chronic liver disease, etc.) or complications (multiorgan failure, encephalopathy, etc.) were excluded from the study. Result: The clinical features of the study population, where all patients suffered from both fever and anorexia. 60% of patients had vomiting, 54.4% had diarrhea, half had abdominal pain, 43.3% had constipation, and only 3(3.3%) patients had myalgia. According to the Widal test report, 56 (62.2%) patients were reported positive, and 34 (37.8%) patients were reported negative. In the Blood C/S test report, 56 (62.2%) reported negative and 34 (37.8%) patients reported positive. The study population by the total leucocyte count, 45% of patients had >11000 count/mm3, 32.81% of patients had <4000 count/mm3, and 21.88% of patients had 4000-11000 count/mm3. Conclusion: Our findings indicate variability in disease presentation in adults compared to children, in different regions and in resistant vs sensitive cases. Majority of studies are from hospitalized cases, and are not disaggregated by age. Despite higher complications in MDR enteric fever, case fatality rate are comparable to sensitive cases, with an overall hospital based CFR of 2%, which is similar to recent global estimates. [ABSTRACT FROM AUTHOR]