1. Weak D Type 4.2.2 (DAR1.2) in an African child: Serology and molecular characterization.
- Author
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Orlando N, Putzulu R, Massini G, Scavone F, Piccirillo N, Maresca M, Zini G, and Teofili L
- Subjects
- Africa, Alleles, Black People, Child, Preschool, DNA Mutational Analysis, Erythrocytes cytology, Exons, Genetic Variation, Genotype, Haplotypes, Humans, Mutation, Phenotype, Polymerase Chain Reaction, Blood Grouping and Crossmatching methods, Rh-Hr Blood-Group System genetics, Rho(D) Immune Globulin blood, Serology methods
- Abstract
The weak D phenotype is represented by a group of RHD genotypes that code for alterated RhD proteins associated with a reduced RhD expression on red blood cell. By routine serology, some partial D variants are likely to be missed. In this report we describe the case of a three-year-old Black African child with a "unclear" reaction with monoclonal anti-D. We analyzed the blood sample of the child with different methods to conclude that it is a case of DAR 1.2 (weak D 4.2.2) and that it must be transfused with D negative erithrocytes., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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