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Abstract: Song and Kawakatsu (2012) have shown that the sub-slab fast splitting pattern observed in most subduction zones can be a direct consequence of subduction of the oceanic asthenosphere that has strong radial anisotropy. This model not only explains the non-intuitive trench-parallel splitting pattern in most of subduction zones, but also predicts the trench-normal behavior (fast polarization direction sub-parallel to the absolute plate motion of the incoming plate) observed in several shallow subduction zones. The general validity of such a scenario is crucial to fundamental understandings of the development of mantle anisotropy in sub-lithosphere or/and sub-slab conditions, the nature and formation of oceanic asthenosphere as well as the flow pattern and mass transport near subduction zones. To validate this scenario, we examine SKS splitting patterns observed across the fore-arc in central Alaska. Here the fast splitting direction varies from plate motion sub-parallel near the trench to mostly trench-parallel beyond the 100km slab-isodepth contour, while being strongly variable in between. After taking into account the rotation of anisotropy symmetry in the oceanic asthenosphere with respect to the local plate motion obliquity and down-dip variations in the slab dip, we reproduce a general 90-degree switch in fast splitting direction as well as the back azimuth dependent splitting pattern across the entire fore-arc. The current validation further augments the idea that, apart from anisotropy in the mantle wedge and the subducting slab, subduction of the oceanic asthenosphere is likely to be the dominant source of seismic anisotropy in central Alaska and potentially in many subduction zones. Furthermore, this result also provides alternative views to models of seismic anisotropy in the mantle wedge and on the length scale in which the 3D mantle flow may be important. [Copyright &y& Elsevier]