1. Glomerular filtration rates in healthy Asians without kidney disease.
- Author
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Teo, Boon Wee, Xu, Hui, Koh, Yun Yin, Li, Jialiang, Subramanian, Srinivas, Sinha, Arvind Kumar, Shuter, Borys, Toh, Qi Chun, Sethi, Sunil, and Lee, Evan JC
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ENDOCRINE diseases , *INFECTIOUS disease transmission , *KIDNEY diseases , *GLOMERULAR filtration rate , *CREATININE , *ETHNOLOGY , *ASIANS - Abstract
Aim The Chronic Kidney Disease Collaboration - Epidemiology ( CKD-EPI) glomerular filtration rates ( GFR) estimation equation is believed to estimate GFR more accurately in healthy people but this has not been validated in Asians. We studied the distribution of GFR in a multi-ethnic Asian population without CKD, and compared the performance of measures of GFR estimation, including the CKD-EPI equation, Cockroft- Gault equation, and 24-hour urine creatinine clearances. Materials and Methods A total of 103 healthy volunteers without a history of kidney disease, hypertension, or diabetes underwent GFR measurement using 3-sample plasma clearance of 99m Tc- DTPA. Cockroft- Gault estimated GFR and 24-hour urine creatinine clearances were normalized to body surface area. Results The mean measured GFR was 101 ± 15.8 m L/min per 1.73 m2 and was lowest in Indians (93 ± 12.3 m L/min per 1.73 m2; P < 0.001). The CKD-EPI equation appears to be more accurate for healthy participants. Estimated GFR correlated with measured GFR ( r = 0.57, P < 0.001), and the mean difference is 3.72 ± 14.43 m L/min per 1.73 m2 ( P < 0.001). However, estimating GFR using self-directed 24-hour urine creatinine clearances is poorer than using the CKD-EPI equation. Conclusions GFR estimation using self-directed 24-hour urine collection for creatinine clearance is less accurate than using the CKD-EPI equation. A larger study is required to clarify GFR in healthy Asians, and the association of health outcomes of Asian kidney donors with lower GFR thresholds. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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