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1. Reduced rotavirus vaccine effectiveness among children born during the rotavirus season: a pooled analysis of 5 case-control studies from the Americas.

Author

Premkumar PS, Parashar UD, Gastanaduy PA, McCracken JP, de Oliveira LH, Payne DC, Patel MM, Tate JE, and Lopman BA

Subjects
Americas, Case-Control Studies, Female, Humans, Infant, Male, Treatment Outcome, Rotavirus Infections epidemiology, Rotavirus Infections prevention & control, Rotavirus Vaccines administration & dosage, Rotavirus Vaccines immunology
Abstract

Using data from rotavirus vaccine effectiveness (VE) studies, we assessed whether rotavirus season modifies rotavirus VE in infants. In the first year of life, adjusted VE was 72% for children born during rotavirus season and 84% for children born in other months (P = .01). Seasonal factors may interfere with vaccine performance., (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)

Published
2015
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